How Age-Related Changes in the Brain Affect Cognition

doi:10.1017/9781108552684.004

3 - How Age-Related Changes in the Brain Affect Cognition

from Part I - Models of Cognitive Aging

Published online by Cambridge University Press: 28 May 2020

Anders M. Fjell and

Kristine B. Walhovd

Edited by

Ayanna K. Thomas and

Angela Gutchess

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Ayanna K. Thomas: Affiliation:
Tufts University, Massachusetts
Angela Gutchess: Affiliation:
Brandeis University, Massachusetts

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Summary

Cognition changes with age, and the amount and trajectory of change varies across individuals and functions. In this review, we argue that three general principles characterize adult life-span changes in brain and cognition. (1) Dimensionality: Many features of brain and cognition in aging and neurodegenerative disease represent quantitative differences along a continuum and are not unique to pathology. (2) Early influences – developmental origins of health and disease: Genetic dispositions and early environmental factors, likely even from fetal life, can have lasting impact on the brain and cognition. (3) Influences from a multitude of environmental factors: Current brain state and cognitive function will be determined by a combination of early factors and later environmental influences, often in interaction. These principles entail a model of age-associated cognitive decline and dementia based on dimensions rather than categories, life span rather than aging, and multidimensional systems-vulnerability rather than one major “biomarker.”

Keywords

Aging birth weight cortical thickness development early factors Flynn effect genetic influences interventions magnetic resonance imaging memory navigation plasticity prenatal factors white matter microstructure

Information

Type: Chapter
Information: The Cambridge Handbook of Cognitive Aging
A Life Course Perspective
, pp. 47 - 61
DOI: https://doi.org/10.1017/9781108552684.004 [Opens in a new window]
Publisher: Cambridge University Press
Print publication year: 2020

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