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4 - Prefrontal Cortex Structure and Organisation

Published online by Cambridge University Press:  14 November 2025

Stacey A. Bedwell
Affiliation:
King’s College London
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Summary

The human brain can be divided by both structure and function. Brodmann maps provide a useful way of organising the complex cortical structure based on cytoarchitecture. The basic architecture of the prefrontal cortex shows nothing substantially different to other cortical regions we have a clearer understanding of. However, it remains clear that there must be something anatomically different in the prefrontal cortex for it to be able to carry out such complex functions. Despite vast differences in the functionality of brain regions, topographic connectivity is considered a hallmark feature of cortical structure. However, relatively recent research evidence shows there may be more complexity to the connectivity pattern in the prefrontal cortex when viewed on a fine scale.

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