Chapter 7 provides an overview of best practices in dyadic health interventions that seek to leverage the interpersonal context to optimize the health and well-being of the dyad (both couples and care dyads). The chapter begins with a brief discussion of dyadic interventions, including partner-supported interventions and ripple-effect interventions. We discuss the advantages of taking a dyadic approach to health interventions and provide the findings and key recommendations from recent reviews and meta-analyses across different health (e.g., physical activity, diet) and illness (e.g., cancer, dementia, heart failure, diabetes, pain) contexts. The chapter concludes by providing some specific examples of both established and emerging dyadic health interventions (e.g., Couples Coping Enhancement Training, Exercising Together, FOCUS, SHARE, Recovering Together, Taking Care of Us, Partners in Coping Program, SUCCEED, REPAIR, Let’s Talk Tech). Throughout this chapter, we highlight some of the limitations that have continued to characterize this literature as well as offer recommendations for future research in dyadic health interventions.