Chapter 6 provides an overview of best practices in dyadic qualitative studies – both in terms of their design and their analysis. We begin our discussion of dyadic qualitative research approaches with an overview of qualitative design, noting how decisions about interviewing approaches, recording and coding of the interviews, and the use of prompts should be guided by one’s research objectives and questions. From there, we explore how to approach dyadic qualitative analyses with the goal of treating the dyad as the unit of analysis and the implications of doing so for both analysis and interpretation. We conclude our chapter by discussing best practices in mixed methods designs with special consideration of how to determine which design (e.g., qualitatively driven mixed method, quantitatively driven mixed method) may be best suited to address one’s theoretically-driven dyadic research question.