The book opens by unpacking the 2018 CRISPR baby scandal and its global impacts. Jiankui He’s experiment was a perfect example which exposed the multi-layered ambiguities and contradictions in the realpolitik of the Global South’s drive for influence in frontier research and how power struggles are enmeshed with subaltern anxieties. More importantly, it illuminates why some of the ‘deviance’ manifested by China and India are not country-specific, but underlie shared challenges brought on by a growing diversity of ways of doing research outside of conventional institutions. The chapter demonstrates that bottom-up brokerage, de-territoriality of science and cosmopolitanised civic epistemology are three key trajectories of contemporary science which necessitate us to de-colonise our approach to governance. By the word ‘decolonise’, this book not only refers to the existing epistemic project of decolonial theorisation but also stresses a more fundamental meaning of being able to think outside of scientific ‘colonies’. That is, established social space and interactive order that govern a group of individuals with similar interests or are committed to a certain type of behaviour. The chapter introduces ‘national habitus’ as an analytical tool to substantiate what decolonial theorists have called the capacity to ‘think from and with’ global others.