Manipulation of amniotic fluid volume

doi:10.1017/CBO9780511997778.015

Chapter 10.1 - Manipulation of amniotic fluid volume

Homeostasis of fluid volumes in the amniotic cavity

from Section 2 - Fetal disease

Published online by Cambridge University Press: 05 February 2013

Marie H. Beall and

Edited by

Anthony Johnson and

Mark D. Kilby: Affiliation:
Department of Fetal Medicine, University of Birmingham
Anthony Johnson: Affiliation:
Baylor College of Medicine, Texas
Dick Oepkes: Affiliation:
Department of Obstetrics, Leiden University Medical Center

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Summary

Introduction

Human pregnancies contain large amounts of water in several compartments, including the fetal body, the placenta and membranes, and the amniotic fluid (AF). This water circulates within the conceptus and also between fetus and mother. Normal acquisition and circulation of water is critical to fetal health and development and abnormal amounts of water, evidenced as insufficient (oligohydramnios) or excessive (polyhydramnios) amounts of AF, are associated with impaired fetal outcome, even in the absence of structural fetal abnormalities. This chapter will review the current understanding of water flow into the gestation and into and out of the amniotic cavity, and will review evidence suggesting that the fetus may regulate the AF volume.

Fetal water compartments

The fetal body is composed largely of water. A preterm fetus may be almost 90% water, although near term the proportion is closer to 70% [1, 2]. A 3500 g term human fetus would therefore contain about 2500 ml of water, 350 ml of which are in the vascular compartment, 1000 ml in the intracellular space, and the remainder extracellular [3]. Similarly, the placenta is approximately 85% water [4]; the term fetus would therefore devote about 500 ml of water to the placenta. Lastly, the fetus has a variable, but relatively large, amount of water stored in the amniotic cavity – the AF. Although AF volume is much less related to fetal size, a normal term fetus would have 500–1200 ml [5] in the AF (Figure 10.1.1).

Keywords

membrane water gestation homeostasis human pregnancies placenta fetus amniotic cavity amniotic fluid

Information

Type: Chapter
Information: Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
, pp. 128 - 136
DOI: https://doi.org/10.1017/CBO9780511997778.015 [Opens in a new window]
Publisher: Cambridge University Press
Print publication year: 2012

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