Low-Grade B-cell Lymphomas with Plasmacytic Differentiation

doi:10.1017/9781009397797.004

Chapter 4 - Low-Grade B-cell Lymphomas with Plasmacytic Differentiation

from Section 1 - Mature B-cell and Plasma Cell Neoplasms

Published online by Cambridge University Press: 20 May 2026

Andrés E. Quesada and

Pei Lin

Edited by

Wei Wang and

Sa A. Wang

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Wei Wang: Affiliation:
The University of Texas MD Anderson Cancer Center
Sa A. Wang: Affiliation:
The University of Texas MD Anderson Cancer Center

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Summary

Mature B-cell lymphomas can exhibit considerable plasmacytic differention, the most typical examples of which are lymphoplasmcytic lymphoma (LPL) and marginal zone lymphoma (MZL). The degree of plasmacytic differentiation can sometimes blur the lines between a B-cell lymphoma and a plasma cell neoplasm by morphology or immunohistochemistry. However, characteristic immunophenotypic features by flow cytometry can facilitate this distinction, which is of particular importance for clinical management. This chapter focuses on the applications of flow cytometry in characterizing the immunophenotypic features of LPL and MZL and their key distinctions from each other, plasma cell neoplasms, and other diagnostic challenges.

Keywords

B-cell lymphoma plasmacytic differentiation lymphoplasmacytic lymphoma marginal zone lymphoma immunophenotype flow cytometry

Information

Type: Chapter
Information: Flow Cytometry in Hematolymphoid Neoplasms
A Comprehensive and Practical Guide to Diagnosis
, pp. 29 - 36
DOI: https://doi.org/10.1017/9781009397797.004 [Opens in a new window]
Publisher: Cambridge University Press
Print publication year: 2026

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