NK-large Granular Lymphocytic Leukemia

doi:10.1017/9781009397797.015

Chapter 15 - NK-large Granular Lymphocytic Leukemia

from Section 2 - Mature T-cell and NK-cell Neoplasms

Published online by Cambridge University Press: 20 May 2026

Min Shi,

Michael M. Timm and

Dragan Jevremovic

Edited by

Wei Wang and

Sa A. Wang

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Wei Wang: Affiliation:
The University of Texas MD Anderson Cancer Center
Sa A. Wang: Affiliation:
The University of Texas MD Anderson Cancer Center

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Summary

This chapter outlines the key immunophenotypic features of NK-large granular lymphocytic leukemia (NK-LGLL) and highlights the use of NK-cell receptor patterns, analyzed through flow cytometry, to establish NK-cell clonality. It also emphasizes the essential differences between NK-LGLL and its mimics, such as reactive NK-cell proliferation, NK-cell clones of uncertain significance, and aggressive NK-cell leukemia.

Keywords

NK-large granular lymphocytic leukemia; NK-LGLL; NK-cell receptor killer cell immunoglobulin-like receptor KIR immunophenotype flow cytometry NK-cell clones of uncertain significance NK-CUS

Information

Type: Chapter
Information: Flow Cytometry in Hematolymphoid Neoplasms
A Comprehensive and Practical Guide to Diagnosis
, pp. 129 - 136
DOI: https://doi.org/10.1017/9781009397797.015 [Opens in a new window]
Publisher: Cambridge University Press
Print publication year: 2026

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References

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