Focusing on the ‘keeping’ and ‘cure’ of frantic persons, Chapter 5 explores the ideational link between ‘reason’ and ‘rule’ which – in the minds of contemporaries – justified these interventions. If the ‘ruling faculties’ of the human mind were impaired, this merited the placement of the affected individual under the ‘rule’ of others. If the subject was an adult male, the result was a rapid and often chaotic reshuffling of power relations within the home and the wider community. Looking at how householders, parishioners, physicians, mayors, and local magistrates responded to frenzy, this chapter shows how the ideas explored in Chapters 1–3 changed the lives of those who received the diagnosis. It suggests that, if the high premium placed on the faculty of the ‘reason’ served to shore up the rigidly hierarchical order of social relations which obtained in early modern England (encompassing rank, age, gender, and species), frenzy exposed the fragility of that same order.