MicroRNAs: From Basic Science to Disease Biology

Sidney  Altman; Victor R. Ambros

doi:10.1017/CBO9780511541766

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their discovery has revolutionised both basic biomedical research and drug discovery. Expression levels of miRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development.

'… comprehensive and detailed … compiled logically … informative and easy to read.'

Source: Microbiology Today

'… a useful reference guide for those interested in miRNA …'

Source: Immunology News

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Contents

21 - Real-time quantification of miRNAs and mRNAs employing universal reverse transcription
pp 283-292
- By Gregory J. Hurteau, Ordway Research Institute 150 New Scotland Avenue Albany, NY 12208 USA, Simon D. Spivack, Human Toxicology & Molecular Epidemiology Wadsworth Center NYS Department of Health Albany, NY 12201 USA, Graham J. Brock, Ordway Research Institute 150 New Scotland Avenue Albany, NY 12208 USA
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V - MicroRNAs in disease biology
pp 293-294
- By Krishnarao Appasani, Founder and Chief Executive Officer GeneExpression Systems, Inc. PO Box 540170 Waltham, MA 02454 USA
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22 - Dysregulation of microRNAs in human malignancy
pp 295-308
- By Kathryn A. O'Donnell, Program in Human Genetics and Molecular Biology Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD 21205 USA, Joshua T. Mendell, Program in Human Genetics and Molecular Biology Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore, MD 21205 USA
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23 - High throughput microRNAs profiling in cancers
pp 309-321
- By Muller Fabbri, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Ramiro Garzon, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Amelia Cimmino, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, George Adrian Calin, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA, Carlo Maria Croce, Center for Human Cancer Genetics The Ohio State University Comprehensive Cancer Center 385L Comprehensive Cancer Center 410 West 10th Avenue Columbus, OH 43210 USA
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24 - Roles of microRNAs in cancer and development
pp 322-337
- By Andrea Ventura, Massachusetts Institute of Technology Department of Biology and Center for Cancer Research 40 Ames Street, E17-518 Cambridge, 02139 MA USA, Madhu S. Kumar, Massachusetts Institute of Technology Department of Biology and Center for Cancer Research 40 Ames Street, E17-518 Cambridge, 02139 MA USA, Tyler Jacks, Massachusetts Institute of Technology Department of Biology and Center for Cancer Research 40 Ames Street, E17-518 Cambridge, 02139 MA USA
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25 - miR-122 in mammalian liver
pp 338-349
- By Jinhong Chang, Fox Chase Cancer Center 333 Cottman Avenue Philadelphia, PA 19111 USA, John M. Taylor, Fox Chase Cancer Center 333 Cottman Avenue Philadelphia, PA 19111 USA
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26 - MiRNAs in glioblastoma
pp 350-362
- By Silvia Anna Ciafrè, Experimental Medicine and Biochemical Sciences University of Rome Via Montpellier 1, Rome 00133 Italy
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27 - Role of microRNA pathway in Fragile X mental retardation
pp 363-371
- By Keith Szulwach, Department of Human Genetics Emory University School of Medicine 615 Michael Street, Room 325.1 Atlanta, GA 30322 USA, Peng Jin, Department of Human Genetics Emory University School of Medicine 615 Michael Street, Room 325.1 Atlanta, GA 30322 USA
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28 - Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia
pp 372-379
- By Takashi Sonoki, Department of Hematology and Oncology Wakayama Medical University Kimi-idera 811-1 Wakayama 641-8510 Japan, Norio Asou, Department of Hematology Kumamoto University School of Medicine 1-1-1 Honjo Kumamoto 860-8556 Japan
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29 - miRNAs in TPA-induced differentiation of HL-60 cells
pp 380-391
- By Tomoko Kozu, Division of Cancer Treatment Research Institute for Clinical Oncology Saitama Cancer Center 818 Komuro, Ina, Saitama 362-0806 Japan
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30 - MiRNAs in skeletal muscle differentiation
pp 392-404
- By Irina Naguibneva, Laboratoire Oncogenese, Differenciation et Transduction du Signal CNRS UPR 9079 Institut Andre Lwoff Batiment B, 1er Etage 7 rue Guy Moquet 94800 Villejuif France, Anna Polesskaya, Laboratoire Oncogenese, Differenciation et Transduction du Signal CNRS UPR 9079 Institut Andre Lwoff Batiment B, 1er Etage 7 rue Guy Moquet 94800 Villejuif France, Annick Harel-Bellan, Laboratoire Oncogenese, Differenciation et Transduction du Signal CNRS UPR 9079 Institut Andre Lwoff Batiment B, 1er Etage 7 rue Guy Moquet 94800 Villejuif France
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31 - Identification and potential function of viral microRNAs
pp 405-426
- By Finn Grey, Vaccine & Gene Therapy Institute Oregon Health & Sciences University Portland, OR 97201 USA, Alec J. Hirsch, Vaccine & Gene Therapy Institute Oregon Health & Sciences University Portland, OR 97201 USA, Jay A. Nelson, Vaccine & Gene Therapy Institute Oregon Health & Sciences University Portland, OR 97201 USA
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32 - Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase
pp 427-442
- By Yoichi Robertus Fujii, Molecular Biology and Retroviral Genetics Group Division of Nutritional Sciences Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya 467-8603 Japan
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VI - MicroRNAs in stem cell development
pp 443-444
- By Krishnarao Appasani, Founder and Chief Executive Officer GeneExpression Systems, Inc. PO Box 540170 Waltham, MA 02454 USA
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33 - MicroRNAs in the stem cells of the mouse blastocyst
pp 445-466
- By Hristo B. Houbaviy, Department of Cell Biology University of Medicine & Dentistry of New Jersey Two Medical Center Drive Stratford, NJ 08084-1489 USA
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34 - The role of miRNA in hematopoiesis
pp 467-475
- By Michaela Scherr, Hanover Medical School Center for Internal Medicine Department of Hematology and Oncology Carl-Neuberg Strasse 1 D-30623, Hanover Germany, Matthias Eder, Hanover Medical School Center for Internal Medicine Department of Hematology and Oncology Carl-Neuberg Strasse 1 D-30623 Hanover Germany
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35 - MicroRNAs in embryonic stem cell differentiation and prediction of their targets
pp 476-488
- By Yvonne Tay, Stem Cell and Developmental Biology Genome Institute of Singapore 60 Biopolis Street, #02-01, Genome Singapore 138672, Andrew M. Thomson, Stem Cell and Developmental Biology Genome Institute of Singapore 60 Biopolis Street, #02-01, Genome Singapore 138672, Bing Lim, Stem Cell and Developmental Biology Genome Institute of Singapore 60 Biopolis Street, #02-01, Genome Singapore 138672
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36 - Generation of single cell microRNA expression profile
pp 489-496
- By Fuchou Tang, The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology University of Cambridge Tennis Court Road Cambridge CB2 1QR United Kingdom, Kaiqin Lao, Advanced Research Technology Applied Biosystems 850 Lincoln Center Drive Foster City, CA 94404 USA, M. Azim Surani, The Wellcome Trust/Cancer Research UK Gurdon Institute of cancer and Developmental Biology University of Cambridge Tennis Court Road Cambridge CB2 1QR United Kingdom
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37 - Piwi-interacting RNAs (piRNAs)
pp 497-511
- By Ergin Beyret, Department of Cell Biology and Yale Stem Cell Center Yale University School of Medicine 333 Cedar Street, SHM I-213 New Haven, CT 06511 USA, Haifan Lin, Department of Cell Biology and Yale Stem Cell Center Yale University School of Medicine 333 Cedar Street, SHM I-213 New Haven, CT 06511 USA
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38 - MicroRNAs in immunology, cardiology, diabetes, and unicellular organisms
pp 512-521
- By Krishnarao Appasani, GeneExpression Systems, Inc. PO Box 540170 Waltham, MA 02454 USA
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Index
pp 522-531
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Plate section
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From Basic Science to Disease Biology

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Contents

21 - Real-time quantification of miRNAs and mRNAs employing universal reverse transcription
pp 283-292

V - MicroRNAs in disease biology
pp 293-294

22 - Dysregulation of microRNAs in human malignancy
pp 295-308

23 - High throughput microRNAs profiling in cancers
pp 309-321

24 - Roles of microRNAs in cancer and development
pp 322-337

25 - miR-122 in mammalian liver
pp 338-349

26 - MiRNAs in glioblastoma
pp 350-362

27 - Role of microRNA pathway in Fragile X mental retardation
pp 363-371

28 - Insertion of miRNA125b-1 into immunoglobulin heavy chain gene locus mediated by V(D)J recombination in precursor B cell acute lymphoblastic leukemia
pp 372-379

29 - miRNAs in TPA-induced differentiation of HL-60 cells
pp 380-391

30 - MiRNAs in skeletal muscle differentiation
pp 392-404

31 - Identification and potential function of viral microRNAs
pp 405-426

32 - Lost in translation: regulation of HIV-1 by microRNAs and a key enzyme of RNA-directed RNA polymerase
pp 427-442

VI - MicroRNAs in stem cell development
pp 443-444

33 - MicroRNAs in the stem cells of the mouse blastocyst
pp 445-466

34 - The role of miRNA in hematopoiesis
pp 467-475

35 - MicroRNAs in embryonic stem cell differentiation and prediction of their targets
pp 476-488

36 - Generation of single cell microRNA expression profile
pp 489-496

37 - Piwi-interacting RNAs (piRNAs)
pp 497-511

38 - MicroRNAs in immunology, cardiology, diabetes, and unicellular organisms
pp 512-521

Index
pp 522-531

Plate section

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Why this information is here

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MicroRNAs

From Basic Science to Disease Biology

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Contents

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