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5 - Migration of Disease

Dengue and Zika across Continents, around Cities, and within the Human Host

Published online by Cambridge University Press:  25 March 2020

Johannes Knolle
Affiliation:
Imperial College London
James Poskett
Affiliation:
University of Warwick
Chandran Kukathas
Affiliation:
London School of Economics and Political Science
Khadija von Zinnenburg Carroll
Affiliation:
University of Birmingham
Filippo Grandi
Affiliation:
United Nations Refugee Agency
Eva Harris
Affiliation:
University of California, Berkeley
Kavita Puri
Affiliation:
BBC
Venki Ramakrishnan
Affiliation:
University of Cambridge
Iain Couzin
Affiliation:
Universität Konstanz, Germany
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Summary

Dengue virus, the cause of tens of millions of cases of dengue annually, and Zika virus, the cause of recent explosive epidemics across Latin America associated with congenital defects and microcephaly, are pathogens with a significant burden on human health and well-being. Beyond their toll on health, these flaviviruses, as the genus is called, share a common evolutionary origin, have each adapted to replicate efficiently in the human host, and are spread by similar species of mosquitoes. These commonalities belie important clinical, epidemiological, and immunological differences between them that necessitate continued research into their respective biology. Moreover, these commonalities and differences have real consequences for control efforts in affected areas around the world.

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