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17 - Drugs and Addiction

Published online by Cambridge University Press:  26 June 2026

Frederick Toates
Affiliation:
Open University
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Summary

Addiction represents conflict between (i) a recognition of a problem and/or (ii) engaging in an activity, while wishing not to engage. Theories of addiction are reviewed: opponent process theory, an adaptive orientation, incentive motivation theory, Wise and Bozarth’s neural model, the incentive sensitization theory and the negative affect model. The wanting part is based in the pathway VTA → NAcc. Sensitization is rooted in this pathway. There is overlap in brain regions excited by drug and erotic images. Orbitofrontal cortex and insula have a role in addiction. The chapter discusses the role of social context in drug-taking, and the rat park is described. The Robins’ study on Vietnam veterans is described. The final section is devoted to the development of drug addiction. In the case of humans, family instability is noted. Early adulthood is a particularly dangerous time for acquiring addictions.

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