Genes and brain development

doi:10.1017/CBO9780511735103.003

1 - Genes and brain development

Published online by Cambridge University Press: 04 August 2010

Timothy A. Klempan ,

Pierandrea Muglia and

James L. Kennedy

Edited by

Matcheri S. Keshavan ,

James L. Kennedy and

Robin M. Murray

Show author details

Timothy A. Klempan: Affiliation:
Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Pierandrea Muglia: Affiliation:
Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
James L. Kennedy: Affiliation:
Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Matcheri S. Keshavan: Affiliation:
University of Pittsburgh
James L. Kennedy: Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray: Affiliation:
Institute of Psychiatry, London

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Summary

The processes of neurulation, patterning, neuronal specification, and synaptogenesis, as well as the functional dynamics of neurotransmission, are governed by the coordinated actions of products from a wide array of genes. Neurodevelopmental etiology of schizophrenia is suggested by neuroimaging and postmortem studies revealing significant and replicated lateral ventricular enlargement, hippocampal and gray matter deficits, and cellular disarray, independent of duration of the illness and antipsychotic treatment. This chapter provides an overview of the major mechanisms involved in the development of the mammalian central nervous system (CNS), with specific reference to the identity and patterning of genes that are known to regulate the developmental phases. This pattern of gene expression is related to the etiology of schizophrenia through evidence provided by genetic, postmortem, imaging, electrophysiological, and behavioral investigations of the disorder.

Keywords

brain development cell adhesion central nervous system neurotransmission neurulation neuronal survival neurodevelopmental etiology genes schizophrenia

Information

Type: Chapter
Information: Neurodevelopment and Schizophrenia , pp. 3 - 34

DOI: https://doi.org/10.1017/CBO9780511735103.003 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2004

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