High-risk studies, brain development, and schizophrenia

doi:10.1017/CBO9780511735103.025

23 - High-risk studies, brain development, and schizophrenia

Published online by Cambridge University Press: 04 August 2010

Matcheri S. Keshavan

Edited by

Matcheri S. Keshavan ,

James L. Kennedy and

Robin M. Murray

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Matcheri S. Keshavan: Affiliation:
University of Pittsburgh School of Medicine, Pittsburgh and Wayne State University School of Medicine, Detroit, USA
Matcheri S. Keshavan: Affiliation:
University of Pittsburgh
James L. Kennedy: Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray: Affiliation:
Institute of Psychiatry, London

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Summary

This chapter reviews the several approaches to investigate premorbid risk for schizophrenia. It presents a critical appraisal of the existing studies focusing on the populations at risk for schizophrenia, the issues surrounding study design, predictive and outcome factors identified so far, and the timing of the studies. Studies of premorbid risk, risk for schizophrenia and prospective studies have utilized genetic propensity, neurobehavioral markers, or psychopathology to identify the risk status. The chapter outlines the potential merits and disadvantages of these strategies, reviews the lessons learned from the early first high-risk (HR) studies and presents a rationale for more focused next-generation studies to examine premorbid risk. Recent advances in developmental neurobiology and neuroscience make it reasonable to expect a paradigm shift in research on schizophrenia. It is hoped that the third millennium will usher in a new generation of research studies on high-risk (HR) populations.

Keywords

brain development clinical high-risk strategies cognitive deficits genetic high-risk studies high-risk studies general population cohort studies follow-back and retrospective studies enhanced high-risk strategies neurobehavioral high-risk strategies schizophrenia

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Type: Chapter
Information: Neurodevelopment and Schizophrenia , pp. 432 - 454

DOI: https://doi.org/10.1017/CBO9780511735103.025 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2004

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