The salience of culture is recognized in psychiatric research and practice as the population grows increasingly diverse and complex. It is therefore of great importance to appreciate cultural humility as an essential framework in psychiatric prescribing to improve patient–physician alliance, effective prescribing and overall patient outcomes. The approach of traditional cultural competence training in medical education is limited, and indirectly perpetuates disparities as physicians and other practitioners assume proficiency in patients’ cultures, but cultural humility emphasizes self-reflection and lifelong learning as key ingredients to understanding our culturally and linguistically complex patient population. The challenge of incorporating cultural humility into existing medical curricula include didactic space constraints, lack of mentors, and difficulty in the designing assessment metrics for cultural humility in medical education.