This chapter explores sepsis in the context of the pregnant, or postpartum, woman. Including national tools for the recognition, investigation and management of sepsis. Common causes of maternal sepsis are explored as well as considerations for the baby. Key learning points: Understand the difference between infection and sepsis. Perform a full set of observations, including respiratory rate and temperature, in any woman feeling unwell in pregnancy or the postpartum period. Highlight the use of early warning score charts, e.g. maternity early warning score (MEWS) or modified obstetric early warning score (MOEWS), to document observations and aid the early detection of sepsis. Involve senior clinicians and the multi-professional team early. Early recognition and treatment of sepsis and septic shock improves outcomes. Effective treatment with the Sepsis Six includes early administration of intravenous antibiotics and fluid therapy.