This chapter theorizes place as both an object and an agent of renewal, taking, as its case study, Ben Jonson’s revision of Every Man in His Humour. Although the play was set in Florence when first performed by the Lord Chamberlain’s Men in 1598, Jonson shifts that setting to London when preparing Every Man in His Humour for his 1616 folio. Beneath this remarkable change lie several striking continuities, including Jonson’s repeated allusions to the New World. Such allusions are effectively reprinted in the 1616 folio, and yet they are simultaneously rewritten through Jonson’s change of setting. To trace the effects of such rewriting, the chapter documents the deepening imbrication of England and the New World in the first decades of the seventeenth century, showing, in turn, how Jonson’s revisions of Every Man in His Humour both acknowledge and manage the consequences of this imbrication for his comedy of humors.