While antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit. There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, so they have had to make difficult decisions about treatment options with very limited data. The editors and their internationally distinguished team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment. This timely book will be invaluable to clinicians, neuroscientists, researchers and graduate students.

‘The excellence of this book is the section on special patient populations. They are all extremely well covered … This book will be valuable for researchers, academics who are interested in the scholarly reviews and algorithms of treatments, clinicians with special interest in affective disorders, and any clinician who would like a valuable resource book in their library.’

Source: International Journal of Geriatric Psychiatry

'The book is strong on the psychological aspects and it is pleasing to note that dysthymia - a difficult concept in relation to these disorders - is sensibly handled, as this has often caused confusion in the US/UK literature.'

Source: British Journal of Psychiatry

'It is a good description of current thinking and a useful book to have for reference text.'

Source: Journal of Psychosomatic Research