How do you treat melancholy’s bad feelings? Renaissance therapies for ‘perturbations of the mind’ – the sixth of the Galenic non-naturals – are many and varied. Since melancholy is a disease of the imagination in which the emotions become disturbed, remedies for it must tackle melancholics’ emotional states, known in Robert Burton’s time as the passions. But how far sufferers can treat themselves, and how far they can be aided by others, is a matter open to question. In this chapter, we will see how self-help, good advice, and emotional regulation work as cures for melancholy – and what their limitations are.