A neglected aspect of individual vulnerability is the limits it may pose for epistemological capacity, in particular, how specific circumstances of individual vulnerability may challenge the role individual introspection can play in leading autonomous lives. The chapter proposes and investigates the claim that individual vulnerability can jeopardise the role introspection is usually assumed to play in deciding what course we hope to give our lives. In some cases of vulnerability, individuals may not be able to endorse and take responsibility for choices they make because they don’t trust their introspective knowledge. In this way, vulnerable individuals lose the authoritative grip on their introspective self-knowledge. Yet self-knowledge is a vital condition of individual autonomy: without self-knowledge, individuals lack the internal requirements of personal autonomy. The final part of the chapter discusses of how this aspect of vulnerability plays out for considerations of relational equality.