This chapter traces William Burroughs’ self-imposed exile across the Americas, North Africa, and Europe, arguing that the geographic settings where he lived were integral to the conceptual structure of his work. Rather than treating setting as backdrop or exotic inspiration, Burroughs reimagines place as a set – simultaneously stage, fiction, and experiential filter – through which he explores identity, language, and systems of control. From his ironic travel ethnographies in Junky and The Yage Letters, to the colonial parody of Queer, and the fractured landscapes of Naked Lunch and the cut-up novels, Burroughs engages in a layered literary expatriation that aligns him with, but ultimately distinguishes him from, figures like Bowles, Baldwin, Stein, and Beckett. Focusing on Tangier and Paris as creative epicenters, the chapter argues that Burroughs’ spatial displacements catalyze formal and thematic experimentation. His work reveals a persistent tension between immersive estrangement and mediated construction, exposing alterity not only in foreign cultures, but within language and self.