Migrant population presents specific mental health care needs, as they face a higher risk of psychological distress. Challenges are presented, including language barriers, socioeconomic conditions, and legal status. Tailored mental health services are crucial for effectively addressing these needs. However, in Spain, there is limited evidence on the functioning and outcomes of such services. The Servei d’Atenció a la Salut Mental de la Població Migrada (SATMI) has been providing specialised mental health care for migrant population in Barcelona since 1997.

This study aims to describe the sociodemographic and clinical profiles of migrants receiving care through SATMI program. Thus, to analyse their service trajectories in order to inform future improvements in mental health care provision.

This retrospective descriptive study analyses sociodemographic, clinical, and service-use data collected from all individuals who attended SATMI during 2023. Variables include age, sex, nationality, country of birth, language, and need for an interpreter. At the same time, social and clinical data are also included, such as migration-related categories (refugee, unaccompanied minor, homeless, or family reunification), residence permit status, psychiatric diagnosis, and clinical course (including the number and type of sessions). Descriptive statistical analysis is applied to examine participant profiles and attendance patterns.

Preliminary findings indicate that 262 individuals accessed SATMI services in 2023. The majority were men (146; 55,7%). Regarding migration categories, 47 participants were identified as refugees, 18 as unaccompanied minors, and 17 as homeless. Following DSM – V main diagnose criteria, 14 categories were identified. Among them, the most common were (i) trauma and stressor - related disorders (96; 36,6%), (ii) psychotic disorders (40, 15,3%), (iii) depressive disorders (38, 14,5%), and (iv) anxiety disorders (20; 7,6%). Data highlights the diversity of needs addressed within the program.

This study provides data on specialised migrant mental health services in Spain. The results show the complexity of the attended population. This supports the need for specialized multidisciplinary teams. Limited availability of clinical information in this field highlights the importance of implementing systematic data collection for ongoing monitoring of services impact. In a nutshell, such demographic studies support a broader understanding of migrant mental health care needs.

None Declared

Migration is a phenomenon which is increasing worldwide and is known to be a risk factor in the development of mental health issues, including psychotic disorders, especially among asylum seekers and refugees. High rates of anxiety disorders, depression and Post-Traumatic Stress Disorder are well documented, too. Due to lack of awareness of the host country’s healthcare system, migrants often turn to the emergency department (ED) which frequently becomes the entry point for mental healthcare due to stigma, delay in diagnosis and treatment.

The main goal of this study is to analyze socio-demographic and clinical features of migrants who sought care in the ED and were provided with a psychiatric consultation, in order to identify possible correlations with the outcome of such consultations and to compare them with those involving the native population.

Data will be presented from the leading center (Maggiore della Carità University Hospital) of a larger project (IDEALI) which involves several Italian centers. Between January 2024 and March 2025, 91 migrants received a psychiatric consultation in the ED. For each patient socio-demographic and clinical data, as well as features related to ED access and subsequent discharge were collected and compared to those of the 483 Italian patients who received a psychiatric consultation in the same ED and in the same period of time.

Migrant patients accessed the ED mostly on their own or upon referral from their general practitioner/emergency medical service. The most frequent symptoms at presentation were anxiety and psychomotor agitation in both groups. Over the reference period, migrants accounted for only 16% of total ED visits, the majority of which resulted in hospitalization. The most frequent outcome for the psychiatric consultation was discharge or referral to a community mental health center. The majority of the sample had a history of psychiatric disorders, with psychotic and personality disorders being the most frequent diagnoses. Most migrants had previously undergone psychiatric treatments (usually benzodiazepines) and they received medication more frequently in the ED compared to non-migrants.

This study confirms previous literature findings: migrants often rely on ED as the primary entry point to healthcare, including psychiatric services. Cultural and linguistic barriers complicate the access to community services and lead to a higher risk of urgent admissions, coercitive treatments and negative clinical outcomes. The high incidence of psychotic disorders observed in our sample highlights the urgent need to develop culturally competent and multidisciplinary care. Cultural-linguistic mediation, preventive strategies and strengthened continuity of care are essential to ensure equity and improve mental health outcomes in the migrant population.

None Declared

Xanomeline, a muscarinic receptor agonist with preferential affinity for the M₁ and M₄ subtypes, has demonstrated antipsychotic efficacy, thereby revitalizing interest in muscarinic receptor–targeted pharmacotherapy for schizophrenia. To mitigate xanomeline-associated peripheral cholinergic adverse effects, it has been co-formulated with trospium chloride, a peripherally restricted muscarinic receptor antagonist. On 26 September 2024, the United States Food and Drug Administration (FDA) approved the oral co-formulation of xanomeline and trospium chloride for the treatment of schizophrenia in adults (Fabiano et al. ECNP 2025; 92, 62-73). Despite substantial advances in neuropsychopharmacology, the persistent underrepresentation of diverse demographic groups in clinical trials remains a widely acknowledged barrier to both scientific understanding and the equitable translation of research findings into clinical practice.

The present cross-sectional analysis seeks to characterize the demographic composition of participants enrolled in clinical trials evaluating xanomeline–trospium, drawing upon publicly accessible data from ClinicalTrials.gov.

A comprehensive search of ClinicalTrials.gov was performed on the 26 April 2025 (see Figure 1). Trials were included if they met the following eligibility criteria: (1) interventional study design; (2) availability of published results on ClinicalTrials.gov; (3) a primary investigational focus on schizophrenia; and (4) classification as a phase 2, phase 3, or phase 4 clinical trial. For each eligible trial, data were extracted on the National Clinical Trial (NCT) identifier, total sample size, study site location, and participant demographic characteristics, including age, sex, race, and ethnicity.

Five clinical trials conducted in the United States and Ukraine (n = 842) met the inclusion criteria. Black participants comprised 68.76% of the pooled sample, White participants 29.45%, and Asian participants 1.07%. Representation from other racial groups, including American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander, was negligible. At least 8.3% of participants identified as Hispanic or Latino, whereas no fewer than 70.43% were classified as Not Hispanic or Latino; ethnicity data were not reported for trial NCT03697252. Women accounted for 24.7% of participants, and the mean age across trials ranged from 42.5 to 45.9 years (see Table 1). Some trials did not provide complete demographic information.Image 1:

The findings reveal substantial demographic disparities and underscore the imperative for more inclusive and representative recruitment strategies in future clinical trials investigating schizophrenia.

A. Kwaśny Grant / Research support from: Beckley Psytech, Compass Pathways, GH Research, MSD., D. Świeczkowski: None Declared, A. Włodarczyk Grant / Research support from: Karuna Therapeutics., A. Wilkowska Grant / Research support from: Angelini, Biogen, Eli Lilly and Company, Janssen-Cilag, Lundbeck, Polpharma, Sanofi, and Valeant., J. Słupski Grant / Research support from: Actavis, Eli Lilly, Minerva Neurosciences, Sunovion Pharmaceuticals, KCR, Janssen, Otsuka, Apodemus, Cortexyme, MSD, Novartis, Ketabon HMNC Brain Health, Acadia and Karuna Therapeutics., W. Cubała Grant / Research support from: Grants: Acadia, Alkermes, Allergan, Angelini, Auspex Pharmaceuticals, Beckley Psytech, BMS, Celon, Cephalon, Compass Pathways, Cortexyme, Ferrier, Forest Laboratories, GedeonRichter, GH Research, GWPharmaceuticals, HMNC Brain Health, IntraCellular Therapies, Janssen, KCR, Lilly, Lundbeck, Minerva, MSD, NIH, Neumora, Novartis, Orion, Otsuka, Recognify Life Sciences, Sanofi, Servier Honoraria: Adamed, Angelini, AstraZeneca, BMS, Celon, GH Research, GSK, Janssen, KRKA, Lekam, Lundbeck, Minerva, NeuroCog, Novartis, Orion, Pfizer, Polfa Tarchomin, Sanofi, Servier, Zentiva, Consultant of: Advisory boards: Angelini, Celon (ended 2021), Douglas Pharmaceuticals, GH Research, Janssen, MSD, Novartis, Polpharma, Sanofi

Spiritual and religious dimensions of health are often overlooked in psychiatric treatment, despite growing evidence suggesting their relevance in recovery. This study systematically reviews the literature on spiritual or faith-based interventions in inpatient psychiatric settings to evaluate their impact on psychological and emotional outcomes.

To evaluate the role and impact of spiritual and faith-based interventions on psychological and emotional outcomes in adult inpatient psychiatric settings.

To synthesize existing empirical evidence on the feasibility, acceptability, and therapeutic value of integrating spirituality into psychiatric care.

A descriptive systematic review was conducted using PubMed, covering studies published in English between 2010 and 2024. Eligible studies included adult participants (≥18 years) in inpatient psychiatric or residential care who received spiritual interventions such as chaplaincy services, pastoral counseling, group prayer, or spiritually integrated psychotherapy. Outcomes assessed included symptom reduction, coping, therapeutic alliance, patient satisfaction, and spiritual/emotional well-being. Both qualitative and quantitative empirical studies were included. A narrative synthesis approach was used due to heterogeneity in interventions and outcome measures.

Out of 52 records identified, 10 studies met inclusion criteria. Interventions were implemented in diverse psychiatric settings and addressed a wide range of mental health conditions including serious mental illness and co-occurring substance use disorders. Common modalities included group sessions centered on meaning-making, hope, forgiveness, and existential reflection. Several models (e.g., ACTing Spiritually, SPIRIT protocol) demonstrated utility in enhancing coping skills and emotional regulation. Qualitative findings emphasized improvements in emotional expression, interpersonal connection, and reduced isolation. Quantitative results indicated a substantial patient demand for spiritual support, even among non-religious individuals. However, most studies lacked standardized outcome measures or control groups.

Spiritual and faith-based interventions are feasible, acceptable, and appear to complement psychiatric care in inpatient settings. They contribute to patient-centered recovery by addressing spiritual needs and fostering emotional resilience. Despite encouraging findings, further high-quality research is needed to clarify best practices, efficacy, and strategies for integration into interdisciplinary care teams.

None Declared

A significant rise in global temperatures has become evident in recent years. Climate change and global warming are now established realities, not future projections. The impact on human health is increasingly documented, yet the mental health dimension remains underexplored. Anxiety disorders, climate-induced clinical conditions, and the worsening of pre-existing psychiatric disorders constitute urgent challenges. Such consequences may also foster the emergence of new psychopathological disorders.

Early identification of climate- related menta health issues. Preventive interventions to reduce the risk of anxiety,mood and stress related disorders. Comprehensive care approaches integrating psychological support, community resources, and resilience building programs. Training for mental health professionals to recognize and manage emerging climate related psychopathologies.

Various reports highlight the potential increase in post traumatic stress disorders (PTSD) due to the intensification of natural disasters and climate related migration. IPCC (Intergovernmental Panel on Climate Change) reports point to the growing mental health burden associated with climate change. Findings from the NIH (National Institutes of Health) also underscore the psychological consequences of environmental disruptions

Eco-anxiety and solastalgia must be identified and adressed to prevent the onset of new anxiety disorders and potential mood disorder decompensations. The seasonal compenent of bipolar disorder may also be significantly affected to further contribute to mental health disorders. The impact of climat change on addictive behaviors and suicidal tendencies must also be taken into account Early detection, prevention and appropriate management of these conditions should be considered a priority for all mental health professionals

There is an urgent need to conduct and expand studies demonstrating the impact of climate change on human mental health. Climate change represents a risk and vulnerability factor for the deterioration of mental health. Climate action itself can serve as both an intervention and a means of mitigating mental health decline.

None Declared

Climate change is a highly relevant issue. Eco-anxiety is a complex construct that refers to concern or distress related to climate change and its implications for the future. Feelings of hopelessness and helplessness regarding this issue can exacerbate eco-anxiety, partly due to increased public awareness.

The aim is to provide a review of the concept of eco-anxiety and to discuss its challenges for clinical practice.

Literature review on the subject, using databases such as PubMed.

Climate change resulting from global warming is currently affecting both the environment and public health. It can influence mental health directly, indirectly, and through awareness of the issue (Heinz A, Brandt L. Lancet Reg Health Eur 2024; 43:100969). In terms of awareness, this has been increasing due to media coverage. Various studies show that the vast majority of individuals, regardless of age, express concern about environmental issues that affect daily functioning (Baudon & Jachens. Int J Environ Res Public Health 2021; 18:9636). The term eco-anxiety encompasses not only anxiety but also a spectrum of emotions, including fear, anger, exhaustion, and despair. Eco-anxiety can also be understood as an adaptive response to climate threats, with the potential to promote pro-environmental behavior (Betro S. Front Psychiatry 2024; 15:1429571). Focusing on meaning may be important, as it can encourage individuals to trust their beliefs and values and to act adaptively during periods of stress (Betro S. Front Psychiatry 2024; 15:1429571). This may serve as an advantageous coping strategy in the context of climate change. Studies suggest that approaches such as psychoanalysis, analytical psychology, acceptance and commitment therapy (ACT), and mindfulness techniques can provide useful strategies for managing symptoms associated with eco-anxiety (Elliston. Australasian Psychiatry 2024; 32:97). The level of evidence, however, varies, with ACT and mindfulness-based interventions showing the most promising results to date. Dialectical behavior therapy (DBT) may also be helpful in managing catastrophic thoughts related to climate distress by using emotional regulation skills (Elliston. Australasian Psychiatry 2024; 32:97). The starting point for any intervention should be empathetic and non-judgmental listening, rather than reassurance. Currently, several eco-anxiety questionnaires have been developed to assess its various dimensions.

Climate change is one of the greatest health threats of the 21st century. Given its relevance and urgency, more training is needed to equip healthcare professionals with the skills to apply in practice, based on a holistic model. Finally, it is important to emphasize that the goal is not to pathologize eco-anxiety, but rather to understand it as a spectrum.

None Declared

Stigma remains a key barrier to mental health care. Digitalization creates new opportunities for education and support. This paper presents the results of a multilingual media project aimed at overcoming stigma and creating an inclusive environment.

To develop and implement a comprehensive information and communication platform to support patients with mental disorders and their families, reduce stigma, and integrate Russian research into the global scientific community.

A media project, “Creating Connections and Helping,” was initiated. It includes an official website, a scientific journal in Russian and English, and a series of specialized blogs. The scientific basis was confirmed by a 15-year screening survey (n = ~5,000) to assess the need for such resources. Online platform traffic metrics over a two-year period were used to analyze effectiveness.

98% of respondents confirmed a high demand for specialized online resources. Traffic analysis revealed sustained interest: the project’s blogs garnered approximately 5,000 views. Content combining personal experience and practical recommendations proved to be the most popular. The project facilitated international collaboration with scientists from Canada and Italy and contributed to the indexing of the Tomsk National Research Medical Center journal in the Scopus database.

The results demonstrate the high social demand for digital platforms that offer not only information but also emotional support. The project’s success is due to its practical focus and multilingual format, which helps overcome cultural and language barriers. Expert review highlighted areas for improvement, including in-depth statistical analysis and stronger links to national health goals.

The Tomsk National Research Medical Center’s multilingual media project has proven effective as a practical tool for reducing stigma and supporting the community. This model can be adapted in other countries to promote mental health based on principles of inclusiveness and scientific knowledge.

None Declared

Adverse childhood experiences (ACEs) are disproportionately prevalent in early psychosis and may contribute to impairments in social cognition, a core predictor of functional outcomes. However, it remains unclear whether trauma explains unique variance in social cognition beyond the effects of psychosis itself.

To examine whether ACE exposure contributes independently to deficits in social cognition across individuals with first-episode psychosis (FEP), clinical high risk for psychosis (CHR-P), and healthy controls (HC).

In this cross-sectional study, 107 participants were included (39 FEP, 35 CHR-P, 33 HC). ACEs were assessed with the Childhood Trauma Questionnaire (CTQ). Social cognition was measured using a comprehensive battery covering theory of mind (MASC, Hinting, Faux Pas), facial emotion recognition (PERE), and general socio-cognitive functioning (GEOPTE). Linear regression models adjusted for age, sex, and IQ were performed. Three nested models were compared: Model A (ACE), Model B (clinical group), and Model C (combined). Interaction terms tested stage-dependent effects.

Higher ACE exposure was significantly associated with worse performance in specific social cognition domains. Emotional abuse predicted greater socio-cognitive difficulties (GEOPTE; β=0.62, p=0.01), physical and sexual abuse were linked to impaired disgust recognition (β=-0.06 and -0.05, both p=0.02), and emotional neglect was related to reduced Hinting performance (β=-0.11, p=0.02) and recognition of neutral expressions (β=-0.09, p<0.01). Physical neglect was associated with both reduced recognition of neutrality (β=-0.14, p<0.01) and increased recognition of joy (β=0.06, p=0.05). Nested model comparisons showed that adding ACEs improved model fit beyond clinical status, particularly for neutral expressions (ΔR2 up to 0.18, p<0.01). ACE-by-group interactions indicated that negative effects of abuse on disgust recognition were stronger in FEP and CHR-P than in HC.Image 1:

Childhood trauma contributes independently and additively to deficits in theory of mind and emotion recognition in early psychosis. Findings underscore the need to integrate trauma-informed approaches in assessment and intervention for CHR-P and FEP populations.

None Declared

Dementia affects more than 50 million individuals worldwide. It is estimated that almost half of the cases can be attributed to potentially modifiable factors, highlighting the importance of targeting these factors in dementia prevention.

The aim is to provide a review of multidomain interventions for risk reduction and prevention of dementia.

Literature review on the subject, using databases such as PubMed.

At present, there is no cure for dementia. Still, making healthy lifestyle choices is crucial for delaying or preventing its onset. In this context, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was launched in Finland, lasting two years and including individuals at high risk of developing dementia, identified through the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score (Kivipelto M, Mangialasche F, Ngandu T. Lancet Neurol 2018; 17:27). The study focused on regular physical exercise, a Mediterranean-style diet, cognitive and social stimulation and the management of cardiovascular risk factors as measures to prevent or reduce the risk of dementia. The results were promising, showing beneficial effects on cognitive performance, as even small individual changes across multiple risk factors can lead to favorable outcomes when combined (Kivipelto M, Mangialasche F, Ngandu T. Lancet Neurol 2018; 17:27). Since the FINGER study demonstrated that prevention is possible through multidomain interventions, it became essential to adapt, expand, and optimize these findings through the World-Wide FINGERS initiative (Kivipelto M et al. Alzheimers Dement 2020; 16:1078-94). This project incorporates diverse cultural, geographical, and economic settings, providing a platform to identify individuals with different risk profiles and to encourage countries to implement multidomain lifestyle interventions. It also facilitates data and knowledge sharing by identifying globally applicable strategies to prevent or delay the onset and progression of late-life cognitive impairment.

Dementia represents a major public health challenge. The risk of dementia begins to take shape long before old age, highlighting the importance of early prevention. Identifying individuals at higher risk may allow for the development of strategies to prevent or delay the onset of dementia. However, it remains essential to include more low- and middle-income countries, adapting lifestyle interventions to different contexts and ensuring personalization. Longer follow-up periods are also needed to gather further results. Digital platforms could also become a valuable resource for improved monitoring.

None Declared

Autistic traits (ATs) and psychotic experiences (PEs) were often viewed as distinct phenomena, but growing evidence has suggested that both exist on a continuum within the general population. Despite this, research on the co-occurrence of subthreshold symptoms remains limited, particularly in non-clinical populations.

This study aimed to investigate the relationship between ATs and PEs in a large sample of young adults from the general population and to investigate the mediating and moderating variables that may influence this relationship (i.e., Social Pain, loneliness, Alexythymia, childhood trauma).

This cross-sectional study was conducted from February 1st to April 30, 2024.. Data were collected using self-administered questionnaires, including validated Arabic versions of the Autism-Spectrum Quotient, Prodromal Questionnaire-Brief, Social Pain Questionnaire, and Jong-Gierveld Loneliness Scale. Mediation analyses were conducted to explore the indirect effects of social pain and loneliness on the association between ATs and PEs.

The total of partcipants was 7,646 participants aged 18 to 35 (mean age 22.55 ± 4.00 years). Mediation analysis revealed that both loneliness (indirect effect: Beta = .19; Boot SE = .02; Boot CI .16, .22) and social pain (indirect effect: Beta = .04; Boot SE = .01; Boot CI .02, .06) partially mediated the relationship between ATs and PEs. Higher ATs were associated with increased loneliness and social pain, both of which were significantly linked to more severe PEs. Sociodemographic factors, including sex, education level, and smoking status, were also found to be significantly correlated with higher PQ-B scores.

This research has contributed to a better understanding of the complex interplay between ATs and PEs and highlights the importance of addressing these factors for mental health interventions.This study has provided new insights into the mediating roles of social pain and loneliness in the relationship between Ats and PEs.

None Declared

Parental mental illness is a major public health issue due to its frequency and its impact on children’s development. When parents experience psychiatric instability, their ability to meet children’s emotional and educational needs may be compromised, leading to family dysfunction, lack of emotional support, and increased exposure to stress. As a result, children of parents with mental illness are at higher risk of emotional, academic, and social difficulties. Despite this, parental roles and children’s experiences remain neglected within adult psychiatric care.

Framed systemically, illness is a family event: many children act as young carers and experience role reversal, isolation, and stigma.

Evidence from Kidstime, a preventive, multifamily, non-therapeutic model, shows benefits from age-appropriate explanations, peer contact, and a reliable adult, supporting our local implementation.

Implement a multifamily group to:

1. 1. break silence and reduce stigma around parental mental illness;

2. 2. provide children with clear, age-appropriate information and a supportive space;

3. 3. strengthen parents’ confidence and competence;

4. 4. reduce isolation by fostering peer support and links with care teams/community resources;

5. 5. promote prevention at two levels: relapse prevention in parents and mental-health promotion in children.

UMPVE is an eight-session, monthly multifamily psychoeducational program for adults in psychiatric care, their partners, and children aged 5–18. Sessions follow a fixed structure (parallel parent/child groups, creative activities, shared discussion, informal time). Families are referred by their psychiatrist and attend a pre-admission interview; workshops are co-facilitated by a multidisciplinary team (psychiatrists, psychologists, drama facilitator) in a safe, non-stigmatizing setting. A pilot started in December 2024.

Evaluation includes sociodemographic and clinical data, attendance, and qualitative feedback from parents, children, and professionals.

Preliminary observations indicate strong feasibility and acceptability. Parents reported reduced isolation, greater support, and increased confidence in their parental role. Children described the workshops as safe spaces to understand their parent’s illness and express emotions without guilt or fear. Professionals noted improved family communication and a strengthened therapeutic alliance.

These first experiences align with international findings on the benefits of multifamily preventive groups.

UMPVE shows that family-centered, multifamily interventions are feasible and well accepted in adult psychiatry. By addressing children’s needs, supporting parents, and reducing isolation, this program responds to a critical but often overlooked issue. Our early experience suggests that such groups may help break the cycle of intergenerational transmission of mental illness. Broader dissemination and further evaluation are warranted.

None Declared

Children of parents with mental illness face elevated risks of emotional, social, and academic difficulties. Despite these vulnerabilities, adult psychiatric care rarely addresses the parenting role or children’s needs. Multifamily interventions such as the Kidstime model have shown promising results in several European countries, offering children explanations, reducing stigma, and strengthening parents’ confidence. To extend this approach in France, we developed UMPVE (Un Moment Pour Vos Enfants), a Kidstime-inspired program in our adult psychiatry department.

This pilot study aimed to explore the feasibility and acceptability of UMPVE and to describe the sociodemographic and clinical characteristics of the participating families.

UMPVE is a multifamily psychoeducational program including eight monthly workshops for adults in psychiatric care, their partners, and children aged 5–18.

Sessions combine parallel groups for parents and children, creative play, shared discussions, and informal family time. Families were referred by their treating psychiatrist and attended a pre-admission interview. Nine families were included in the pilot group launched in December 2024.

Data collected included sociodemographic and clinical information, family composition, participation rates, and qualitative observations from families and facilitators.

Participants were mainly mothers (89%), often single (67%), unemployed (67%), and socially isolated (44%). Most were followed for mood disorders (56%) or psychotic disorders (22%), generally for less than three years, and 44% had never been hospitalized. Families included between one and four children. Three families discontinued participation after one or two sessions. Among those who continued, parents showed regular attendance (median 5 sessions, range 1–8). Children participated actively across sessions (median 4, range 1–8), while partner involvement was limited (4 partners attended, mostly once).

Observations highlighted children’s engagement in activities, parents’ reflection on their parenting role, and the restoration of parental self-esteem. The program was perceived as neither infantilizing nor judgmental, but as a supportive space fostering open dialogue and resilience.

The pilot demonstrates the feasibility and acceptability of a Kidstime-inspired multifamily program within adult psychiatry. Despite socio-economic vulnerability and frequent isolation, families engaged actively and reported benefits in communication and parental confidence. These preliminary findings are consistent with international literature, underscoring the value of such programs as innovative, non-stigmatizing interventions that address a neglected public health issue. Further evaluation, including qualitative analyses, is warranted to better assess their impact on family dynamics and clinical outcomes.

None Declared

Borderline Personality Disorder (BPD) is a mental disorder that impacts psychosocial functioning, typically resulting in reduced occupational and educational achievement, inability to maintain long-term relationships, increased conflict between partners, and low levels of social support. Patients and family members also report low satisfaction in quality of life. Treatment requires a multidisciplinary approach: psychopharmacological therapy, psychotherapy, psychosocial therapies and caregivers support.

The aim of this study is to explore the feasibility of good practice care in terms of changes in symptom severity and psychosocial functioning in a sample of patients with BPD in a real-world clinical setting.

The study also examines whether training of family members has an impact on the perceived burden of caring and on the development of skills for managing their relative’s disorder.

Fifteen BPD patients at first contact with a Mental Health Service (MHS) of the Department of Mental Health of Spedali Civili Hospital, Brescia were recruited and underwent the following assessment: Toronto Alexithymia Scale (TAS-20), Barratt Impulsiveness Scale (BIS-11), Difficulties in Emotion Regulation Scale (DERS), Zanarini Rating Scale for BPD (ZAN-BPD), Personal and Social Performance Scale (PSP), and Health of the Nation Outcome Scale (HONOS), before and after the interventions. All the patients participated for 9 months in the following evidence-based (EB) interventions for BPD: DBT skills training and psychoeducation with Good Psychiatric Management. A group of patients’ relatives (N=6) underwent for 3 months the Family Connection (FC) group.

Statistical data were calculated using Rstudio software.

Patients (N=14, one drop out) demonstrated improvement in clinical dimensions (TAS-20 p<0.05; BIS-11 p<0.05; DERS p<0.05; ZAN-BPD p<0.001) and in psychosocial functioning (PSP p<0.05; HONOS p<0.05) after the integrated treatment (Wilcoxon test). Patients were then divided into two groups, based on whether or not their parents had completed the FC programme, no significant changes between the two groups were found. A decrease in the perceived burden on family members was observed, although this result did not reach statistical significance.Image 1:

Findings highlight that EB interventions for BPD are feasible and sustainable in a clinical real-world setting. Although preliminary, results indicate a clinical and a psychosocial functioning improvement in individuals with BPD. Starting from these explorative data we argue that EB interventions should be implemented in MHS. The hypothesis is also that involving the family not only helps family members themselves, but also patients. Currently, the small sample size lacks statistical power, but we’ll expect that these results will be confirmed in a larger sample.

None Declared

The use of psychoactive substances constitutes a major public health problem worldwide(1). In the university setting, students have higher consumption rates than the general population of the same age, influenced by factors such as academic stress, social pressure, and adaptation to new environments. Personality traits indicate that certain personality traits are associated with a higher risk of substance use(2)

This study examined the relationship between personality traits and risk level for substance use among undergraduate students at one of the largest private universities in Ecuador.

A cross-sectional survey of 397 randomly selected undergraduate medical students assessed personality traits (Salamanca Questionnaire) and risky substance use (ASSIST) from a population of 1,780. Sociodemographic data were collected. Associations were analyzed using Spearman correlations and mixed-effects logistic regression.

The participants (median age: 21.19 years, 66% women) had the highest consumption rates of alcohol, tobacco, and cannabis (93.2%, 49.6%, and 30.5%, respectively). Regarding overall risk, more than half of the sample (54.4%) were at moderate risk of consumption according to ASSIST criteria. The most frequent personality traits were histrionic, anxious, and borderline (26.7%, 24.4%, and 14.4%, respectively). The analysis revealed that narcissistic, antisocial, and impulsive traits maintained a positive and statistically significant association with the overall risk of substance use. The narcissistic trait showed a positive and significant association (OR = 1.58), indicating that the higher the level of this trait (0-2, 3-4, and 5-6), the greater the likelihood of belonging to a higher risk category of consumption. The antisocial trait has the most pronounced association (OR = 2.38), with each level of this trait more than doubling the probability of having a higher level of general consumption risk.

A distinctive personality profile was identified in medical students with a high presence of emotional dysregulation traits (histrionic, borderline, and anxious traits). High-risk consumption was concentrated exclusively in alcohol and tobacco. Reforms and interventions are needed to promote student well-being and quality of care. Future research should evaluate interventions, conduct better personality diagnoses, and adopt longitudinal designs.

References:

Panamericana de la Salud. (2023). Substance abuse. https://www.paho.org/es/temas/abuso-sustancias

Alonso, A. C. (2014). Study of normal personality traits with the Salamanca Questionnaire [Internet]. https://gredos.usal.es/bitstream/handle/10366/127314/DPPMMLHM_CalderoAlonsoA_RasgospersonalidadcuestionarioSalamanca.pdf?sequence=1&isAllowed=y

None Declared

Borderline personality disorder (BPD) is a highly prevalent and disabling condition associated with multiple psychiatric and somatic comorbidities and significant burden of disease. While many pharmacological agents have been tested for treatment of BPD [1], only few biological therapies are available, and the main treatment modality is Dialectical Behavior Therapy (DBT). At the same time, there have been clinical indications that certain nutrients may have a positive impact on the course of this condition [2]. Specifically, omega-3 fatty acids (O3FA) supplementation has shown some promise.

To evaluate the effects of omega-3 fatty acid supplementation in patients with BPD.

Systematic review of literature.

A systematic literature search was conducted using a series of keywords capturing various O3FA- and BPD-related terms. The initial search yielded 755 entries. After removal of duplicates and title screening, 61 abstracts / full-text articles were reviewed. We have identified 5 studies directly investigating the effects of O3FA on various aspects of BPD during the search. Additionally, existing systematic reviews and meta-analyses were scanned for additional studies, and 2 more studies were added to the search. Full-text review of the included studies showed broad range of outcome measures. Most of the studies reported overall positive effects of O3FA on various clinical aspects of BPD such as impulsivity and affective dysregulation albeit with modest effect sizes.

Limited data on clinical effects of O3FA supplementation for BPD demonstrated an overall positive albeit modest impact on multiple aspects of functioning in BPD. Our research suggests that O3FA supplementation can be safely used as an adjunctive treatment in patients with BPD and warrants further research in this area.

None Declared

Borderline personality disorder (BPD) carries high rates of suicide attempts and death by suicide. While psychotherapy is first-line, pharmacotherapy is frequently used for comorbid symptoms; its association with suicidal outcomes remains uncertain and appears class-dependent.

(1) Quantify the association between pharmacological classes and suicidal outcomes in BPD; (2) compare effects across classes; (3) outline clinical/policy implications.

Systematic searches in MEDLINE/PubMed, Embase, PsycINFO and Web of Science. Eligible designs: observational cohorts/longitudinal analyses and systematic/narrative syntheses; randomised trials without suicidal outcomes were excluded. PRISMA: 1,238 records identified; 1,206 after deduplication; 86 full texts assessed; 7 studies included; 79 excluded. Populations: adults with BPD from clinical services and national registries (mean age 28–35 years; 70–85% female). Primary outcome: suicidal behaviour (attempts/death). Secondary proxies: psychiatric rehospitalisation; composite all-cause hospitalisation/death. Adverse events and medication adherence were not consistently reported.

Primary outcome: in a Swedish national BPD cohort (N=22,601; mean follow-up ≈6.9 years), ADHD medication was associated with a 17% lower risk of suicidal behaviour; mood stabilisers showed a non-significant 3% decrease. Antidepressants were associated with a 38% higher risk, antipsychotics with an 18% higher risk, and benzodiazepines with a 61% higher risk of attempts/death; 316 suicides occurred (~1.4%). Secondary proxies: in a second BPD cohort, ADHD medication was associated with 12% lower psychiatric rehospitalisation and 14% lower composite all-cause hospitalisation/death, whereas antidepressants, antipsychotics and benzodiazepines were associated with 17–38% higher risks; mood stabilisers showed no consistent benefit. Confidence intervals for non-ADHD classes were not consistently reported.

Across recent observational evidence, ADHD medication is associated with lower suicidal behaviour (≈−17%) and lower hospital utilisation (≈−12–14%) in BPD, whereas antidepressants and antipsychotics are associated with higher risk (≈+18–38%) and benzodiazepines with larger increases (≈+61%); mood stabilisers show no consistent benefit.

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Borderline personality disorder (BPD) carries a high burden of suicidality. Clarifying how childhood adversity, attachment insecurity and dissociation relate to suicidal ideation, attempts and death in adults with BPD is essential for targeted prevention, yet evidence remains fragmented.

To quantify associations between early trauma, attachment insecurity and dissociation with suicidal ideation, attempts and death in adults with BPD; to examine subgroup differences (clinical vs community settings; comorbidity); and to explore mediation where reported.

Comprehensive searches of MEDLINE/PubMed, Embase, PsycINFO and Web of Science in adults with BPD. Eligible designs: observational/longitudinal studies and systematic/narrative reviews; findings synthesised narratively (no meta-analysis). PRISMA flow: 1,196 records; 862 after deduplication; 147 full texts; 26 included (16 observational, 6 reviews, 4 longitudinal); 121 excluded (non-BPD 41%, <18 years 29%, no suicidality 21%, other 9%). Across included studies, mean age 29-36 years; 69-74% female; 78% clinical, 22% community.

Aggregated descriptively from included studies and recent reviews: adult BPD prevalences were ideation 74% (69-82%), attempts 56% (48-66%), deaths 4% (2-6%); inpatients typically showed +18-25 percentage points (pp) vs outpatients. Early trauma in 70-85% of patients; multiple exposures approximately +12-22 pp for attempts vs single/none; emotional abuse/neglect +15-28% for ideation. Attachment insecurity >70%; secure <30% and protective (attempt rates lower by 25-40%); where tested, secure attachment mediated ~10-20% of the trauma-suicidality association. Dissociation moderate-severe in 60-75%; associated with +18-30% ideation and with self-harm (non-suicidal self-injury); for attempts, differences vs low dissociation approximately +8-15 pp; longitudinal signals indicated elevated 6-12-month risk at higher dissociation. Subgroups (where reported): age <30 years +8-12 pp for attempts; comorbid major depressive disorder +20-30 pp.

In BPD, early trauma, attachment insecurity and dissociation are key correlates of suicidal vulnerability, with measurable effects of ~10-30 pp on risk indicators. Clinical pathways should implement standardised screening (ACEs/CTQ, attachment measures, DES) and trauma-informed, attachment-focused and mentalisation-based elements alongside dialectical behaviour therapy (DBT).

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Psychotic manifestations in depressive episodes are present in both Major Depressive Disorder (MDD) and Bipolar Disorder (BD). However, empirical research employing dimensional models has been largely restricted to psychotic characteristics when distinguishing between depressive dimensions in MDD and BD.

To explore how psychotic features, in interaction with dimensional personality traits and psychopathological symptoms, delineate MDD from BD.

A cross-sectional study included 168 psychiatric patients (MDD=101, BD=67). Assessments: Personality Inventory for DSM-5 (PID-5), NEO Five-Factor Inventory (NEO-FFI), Brief Symptom Inventory (BSI). ANOVA and regression analyses were conducted.

MDD patients showed higher levels of anhedonia (F=10.71, p<.001), depressivity (F=7.89, p<.01), depression, somatization, anxiety and paranoid ideation (all p<.05) compared to the BD cohort and reported lower extraversion (F=5.15, p<.05). The mean scores for the PID-5 psychoticism facets (eccentricity, cognitive-perceptual dysregulation, and unusual beliefs) did not differ significantly. However, predictive models revealed stronger effects: in MDD, cognitive-perceptual dysregulation predicted depressive symptoms (β=.47, p<.001), while unusual beliefs negatively predicted depressivity (β=-.20, p=.01). In BD, cognitive-perceptual dysregulation was also significant (β=.50, p<.001), alongside interpersonal instability features.

MDD is characterized by anhedonia, depressivity, low extraversion, and psychotic experiences such as paranoid ideation. These traits align MDD with the psychosis spectrum, with anhedonia as a potential vulnerability marker. Elevated paranoid ideation links depression and psychosis, suggesting an affective-paranoia continuum. The overlap of severe MDD and psychotic features indicates shared vulnerability pathways, while BD is less defined by symptoms. DSM-5 traits help refine depressive disorder boundaries. These findings suggest that cognitive-perceptual dysregulation represents a transdiagnostic vulnerability marker, while unusual beliefs and paranoid ideation may help distinguish depressive profiles between disorders.

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Solitude, understood as the pleasant experience of being alone, can represent a positive and meaningful aspect of life. It may be a source of autonomy, creativity, or personal growth. However, the motivations underlying solitude differ among individuals and may be shaped by personality functioning (PF). While some are drawn to solitude for self-determined reasons like self-reflection or growth, others may be motivated by non-self-determined motives such as anxiety or withdrawal tendencies, particularly relevant in the context of impaired PF.

The study aimed to examine motivational patterns for solitude in individuals with varying levels of PF, with a focus on those experiencing impaired functioning.

A total of 1736 participants (1248 women, mean age 37.42 ± 12.14; 152 with severe/extreme PF impairment), divided into five levels of PF (from none to extreme), completed the Motivation for Solitude Scale–Short Form. Analyses included ANOVA to examine group differences and K-means clustering to identify motivational profiles related to solitude.

Differences in motivations have emerged, where individuals with more impaired PF were more likely to endorse anxiety-driven motivations for spending time alone. Additionally, four motivational clusters with two interconnected main dimensions have been identified: 1) solitude motivated by anxiety and discomfort when around others, and 2) solitude driven by the pursuit of self-reflection, or intrapersonal contact. Subgroups have been identified, and among those driven by anxiety, a subgroup also valued self-reflection and connection, while another did not. Similarly, among individuals without anxiety toward others, one subgroup emphasized self-reflection and connection over the other.

The findings demonstrate that the solitude motivations of people with and without impaired PF are not uniform but are driven by the presence or absence of anxiety, and by valuing self-reflection and connection. For those with impaired personality functioning, anxiety-driven solitude was more common, but even then, half of them were able to use and value the solitude for self-reflection, creativity, and connection. The findings suggest a potential for promoting self-reflection and other self-determined drivers while being alone among those who do not yet value it, which could support their mental health and personal development.

This study has been supported by the Czech Science Foundation under grant nr. 24-10889S.

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Personality disorders (PD) are a heterogeneous group of mental disorders characterized by maladaptive patterns of thinking, feeling, perceiving, and behaving. It is estimated that approximately 12% of the general population in Western countries meets the criteria for a PD diagnosis (Volkert et al., 2018).

Borderline Personality Disorder (BPD) is a PD characterized by a persistent pattern of instability in interpersonal relationships, self-image, emotions, and behavior. PDs have been associated with higher psychiatric comorbidity, 85% of people whith PD diagnosis have at least one other mental disorder of the DSM-5. They also have higher rates of self-harm, suicidal ideation, and suicide risk (Hiroeh et al., 2001).

The TREBEA outpatient program is a comprehensive treatment for patients with BPD, which has an interdisciplinary and cross-cultural approach.This program takes place in Gipuzkoa, an area in northern Spain located in the Basque Country. Most interventions are based on dialectical behavioral therapy (DBT), most validated therapy and empirical evidence for the treatment of BPD (Gale et al., 2022).

The TREBEA program would have three main objectives:

1. 1. Clinical: Implementation of validated and effective therapeutic interventions for patients with BPD.

2. 2. Research: Evaluation of the effectiveness of interventions implemented in our population and study of factors that influence the clinical course of patients with BPD.

3. 3. Academic: Conducting training activities for the Gipuzkoa mental health network and training therapists and trainees

Patients are referred from 13 mental health centers in Gipuzkoa, part of the Basque country (nothern Spain).

The assessment includes an extensive questionnaire on sociodemographic data, which provides information on medical history, clinical course, current symptoms, comorbidities, pharmacological treatment, psychosocial functioning, and other significant factors.

In adition, we also include a structured interview, The Diagnostic Interview for Borderlines-Revised (DIB-R) and various self-report questionnaires are administered, such as CORE-OM, BSL-23, and ICG-TLP.

This assessment is conducted before and after the intervention. The program lasts 16 weeks and is based on Dialectical Behavior Therapy (DBT). Patients can complete up to 32 weeks.

Patients included in the TREBEA program show a significant reduction in the frequency of self-harming and impulsive behaviors, a decrease in symptom severity, and an improvement in psychosocial functioning (Image 2). In addition, there is a reduction in the number of emergency room visits and hospital admissions at the end of the program and six months after the intervention.Image 1:

The TREBEA program has been successfully implemented and has proven effective in reducing symptom severity and increasing patient functionality.

None Declared