The Altai Republic (AR) is a national republic of the Russian Federation (RF), where the indigenous people – Altaians live, and where a high death rate from suicide is recorded.

To analyze the dynamics of mortality from suicide in the AR for the period from 1990 to 2019.

Data on mortality of the population were obtained from the Russian databases of demographic indicators. The data were analyzed in terms of indicators standardized per 100,000 population.

In the AR, as well as in the RF as a whole, there has been an increase in the level of suicide since 1990, but in Altai it lasted for a longer period of time – for 13 years. Throughout the entire period, the suicide rates in the AR have consistently exceeded the all-Russian indicators by 1.5-3 times, and by 2019 the gap in indicators has doubled compared to 1990. The curve of mortality from suicide in the AR has a fluctuating character with spontaneous peaks, in contrast to the curve in the RF that has the form of a “plateau”.

In the AR, the mortality rate from suicide consistently exceeds the all-Russian indicators, by 2019 the gap in indicators has doubled. The mortality curve is fluctuating, which we associate with clustering of suicides. This phenomenon requires further study.

No significant relationships.

The ongoing debate regarding the treatment efficacy for negative and cognitive symptoms in schizophrenia is a subject of continuous frustration among psychiatrists. These symptoms are reputedly hard to tackle therapeutically and their impact on long-term functional prognosis made them an important target for the maintenance treatment.

To review the literature in order to find the most adequate treatment options for negative and cognitive symptoms of schizophrenia.

A literature review was performed through the main electronic databases (PubMed, CINAHL, SCOPUS, EMBASE, www.clinicaltrials.gov) using the search paradigm “schizophrenia” AND “negative symptoms” AND “cognitive symptoms” AND “pharmacological treatment”. All papers published between January 2000 and August 2021 were included.

The efficacy of atypical antipsychotics over cognitive dysfunctions in schizophrenia decreases with time, without significant differences between the agents. Clozapine, amisulpride, olanzapine, and risperidone have superior efficacy over positive and negative symptoms, with small to moderate effect sizes. Meta-analyses show decreased severity of negative symptoms during treatment with atypical antipsychotics, especially with clozapine, amisulpride, olanzapine, zotepine, and risperidone. Atypical antipsychotics had a superior effect over neurocognitive domains when compared to the typical antipsychotics. Newer atypical antipsychotics, with partial D2/D3 agonism, are preferred to other atypical agents, although based on a low level of evidence. Antidepressants, especially mirtazapine, may be a solution for negative symptoms, while modafinil/armodafinil is also useful as an add-on.

Although new therapeutic options are explored, there is a paucity of encouraging results from the pipeline regarding the treatment efficacy over negative/cognitive symptoms.

No significant relationships.

All healthcare had to rapidly adjust to covid-19; remote options were implemented at pace and unnecessary face to face contact minimised, with infection prevention and control taking primacy. Many research projects were suspended and some clinical researchers moved to frontline care. For psychiatric academic trainees, covid-19 affected recruitment, and risked delaying work on research degrees such as PhDs, potentially beyond the timeframe of a grant, leading to funding uncertainties. Those valuable casual conversations with senior colleagues in the café stopped and with many schools closed, parents had extra pressures on their time at home. In the UK the government prioritised “Urgent Public Health” (UPH) studies and took a co-ordinated approach to research approvals and recruitment strategies, contributing to the success of covid-19 platform trials such as RECOVERY. While initially only a minority of UPH studies were open to people with serious mental illnesses, now the effect of the pandemic on mental health has become a research priority. In parallel, service planners recognised the value of emergent research in informing decision-making creating de facto learning health systems. While covid-19 interrupted research as we knew it, it necessitated new ways of working, some of which will persist. These included an increase in remote data collection, allowing greater access to research opportunities for potential participants, along with more efficient research approval and evidence dissemination pathways.

No significant relationships.

Inflammation and neural plasticity play a significant role in major depressive disorder (MDD) pathogenesis and cognitive dysfunction. The olfactory neuroepithelium (ON), closely related to the central nervous system (CNS), allows a non-invasive, low-cost study of neuropsychiatric disorders. However, few studies have used ON cells to ascertain them as biomarkers for MDD.

Determine the relationship between inflammatory/neural plasticity markers and cognitive functioning in MDD patients and healthy controls.

Sample: 9 MDD patients and 7 healthy controls. Exclusion criteria: other Axis I mental disorders (patients) or any mental disorder (controls) and any inflammatory, autoimmune, or CNS diseases. Assessment: sociodemographic, clinical, and cognitive variables (CANTAB) were recorded. mRNA was isolated from ON cells and MAPK14, IL6, TNF-α, Mecp2, BDNF, GSK3, GRIA2, and FosB gene expression levels were quantified using quantitative polymerase chain reaction.

MDD patients showed decreased levels of BDNF (p=0.022), GSK3 (p=0.027), and working memory (p=0.024) compared with healthy controls. In healthy controls, planning was positively correlated with NRF2, BDNF, and MAPK14 gene expression. In MDD patients no correlation between cognitive parameters and inflammation/neural plasticity biomarkers was found.

These results reveal that: (1) Plasticity biomarkers such as BDNF and GSK3 could be useful diagnostic tools for MDD (2) MDD is associated with working memory deficits; (3) no association could be determined between planning and NRF2, BDNF, and MAPK14 gene expression in MDD and (4) the ON is a promising model in the study of neuropsychiatric disorders.

No significant relationships.

Internet addiction (IA) is reported to cause significant negative psychosocial consequences. The gender specificity of psychological characteristics that are potentially significant for the formation of IA remains understudied.

To identify gender-related differences in the psychological characteristics of people with IA.

100 subjects aged 16-34 years who scored 65 points or more on the Chinese Internet Addiction Scale (CIAS) were identified and divided into 2 groups by gender: group 1 (54 men) and group 2 (46 women). The individual psychological characteristics were assessed with: the Liebowitz Social Anxiety Scale (LSAS); the Bass-Perry Aggression Questionnaire (BPAQ); the Emotional Regulation Questionnaire (ERQ); the Adverse Childhood Experiences International Questionnaire (ACE-IQ); a short version of the Five-factor Personality Questionnaire (TIPI-RU) and the Cloninger Temperament and Character Inventory (TCI-125).

Women were significantly more likely to experience fear of situations of interpersonal contact and action in public places (p=0.027). They experienced significantly more sexual violence in childhood (p=0.032) and were more likely to have personality traits such as “reward dependence” (p=0.002), “persistence” (p = 0.046), and “self-transcendence” (p=0.002). Men demonstrated physical aggression (p=0.009), suppressed emotions (p=0.019) significantly more often than women and characterized themselves as emotionally stable (p=0.048).

The gender differences identified in the cohort of individuals with IA can potentially be considered specific for this contingent, although such gender relationships can be observed in other forms of addiction and in the general population. The specificity of gender differences may reflect individual psychological markers of increased vulnerability to developing IA.

The study was financially supported by Russian Foundation for Basic Research within the framework of scientific project No 18-29-22079.

Psychosocial functioning is an an important issue in the follow-up processes of patients with bipolar disorder. Potential predictors of functional impairment in bipolar disorder may give a chance to improve functioning in this group of patients.

We aimed to assess the differences between patients with bipolar disorder and healthy controls due to childhood traumas, attachment styles, dysfunctional attitudes, affective temperaments and to assess which of these factors may significantly predict the overall functional impairment in patients with bipolar disorder.

63 remitted patients with bipolar disorder and 61 healthy controls were enrolled in the study. Asessment was conducted using a sociodemoghraphic and clinical questionnaire, Hamilton Depression Rating Scale 17-item version (HAM-D-17) and the Young Mania Rating Scale (YMRS), Childhood Trauma Questionnaire(CTQ-28), Relationship Scales Questionnaire (RSQ), Dysfunctional Attitudes Scale (DAS), Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A) and Functioning Assesment Short Test (FAST).

In the patient group scores of childhood traumas, dysfunctional attitudes, cyclothymic, depressive and anxious temperaments, all domains of functional impairment scores except financial issues, and overall functional impairment scores were significantly higher than the control group. Besides this, secure attachment scores were significantly higher in the control group. In the regression analysis anxious temperament and subclinical depressive symptoms significantly positively predicted functional impairment and hyperthymic temperament significantly negatively predicted functional impairment in patients with bipolar disorder.

In the assessment of functioning of patients with bipolar disorder subclinical depressive symptoms, hyperthymic and anxious affective temperament styles might be taken into consideration.

No significant relationships.

The main scientific task of the study is at the intersection of two fundamental areas of psychology - self-regulation of human mental states and management of educational activities. In the context of these problems, we study the self-regulation of states in academic activities.

The purpose of the study is to show the patterns of mental organization of the person that ensure the regulation of states.

The theoretical basis of the study is the system approach. The typical methods and techniques of self-regulation of states, as well as the influence of mental structures on students’ self-regulation have been studied. To solve the problems, standardized psychological tests have been used (23 methods, 303 indicators). The research involved 206 students.

We have revealed the features of the relationship between the quality of students’ subject training, regulatory abilities and mental states. It indicates that the effectiveness of students’ mental states self-regulation significantly affects the productivity of the semester exam. It has been established the properties of the personality providing high efficiency of self-regulation (adequacy, awareness, independence and assertiveness). Students with high self-regulation efficiency use a wide range of regulatory means.

The study of the influence of the mental structures on self-regulation and regulatory abilities of students confirmed the hypothesis that characteristics of mental organization play the central role in the regulation of psychological states. The research has been carried out with the financial support of the RFBR, project No. 19-29-07072.

No significant relationships.

Alteration of GABergic neurotransmission is accused to be sharing in the cognitive impairment in schizophrenia. Exploring the relation between the neuronal expression of GABergic genes and cognitive impairment in living patients through modeling of schizophrenia is an important step to know more about the core of the pathophysiology of this disorder

Altered genetic expression of GAD 67 may have an important role in the pathophysiology of cognitive impairment in schizophrenia

. Reprogramming of human fibroblasts into human induced pluripotent stem cells (hIPSc) then neuronal differentiation was performed in 20 patients presenting with schizophrenia and 20 matched controls. Real time Polymerase chain reaction was done for measurement of genetic expression of GAD 65, GAD 67 and GABA beta 2. The Digit Symbol task, block design, block design task and similarities tasks from the Wechsler Adult Intelligence Scale., Trail A and Trail B making tests in addition to Rey-Osterrieth Complex Figure Test (ROCF) were applied to measure cognitive functions .

There were lower means of GAD65, GAD67 and GABA beta2genetic expression in the patients group with significant statistical difference between the 2 groups. The down regulation of GAD 67 in patients presenting with schizophrenia is positively correlated with impairment in executive functions.

GAD 67 gene expression had the most significant correlations with the cognitive assessment in both patients and controls. The presence of those statistically significant correlations in both groups points to the possible role of GAD 67 gene functioning in the pathophysiology of cognitive impairment in schizophrenia

No significant relationships.

70-year-old male with previous diagnosis of bipolar disorder and poor adherence. In the past months, he showed incipient behavioral alterations, for which he entered psychiatry service. During adressment, frequent memory failures, isolation, apathy and mutism were identified, clasifying the case as a possible dementia. A CT-scan was performed, revealing bilateral, simetrical calcifications of the basal ganglia, compatible with Fahr’s syndrome.

Review of the available literature regarding Fahr’s syndrome, a rare condition witch can lead to a wide spectrum of neurological, motor and behavioral symptoms.

A bibliographic revision has been carried out. Sources used: Google scholar, PubMed.

Fahr’s syndrome is characterized by symmetric and bilateral calcification of the basal ganglia, as well as other areas related to motor functions, such as the cerebellum. It is believed that it has an autosomal dominant inheritance, and the symptoms appear between the ages of 40 and 60. The spectrum of clinical manifestations includes motor disorders such as parkinsonism or chorea. The appearance of dementia or psychiatric disorders, such as schizophrenia like psychosis or mood disorders, are also common. Also pyramidal symptoms, cerebellar dysfunction, speech difficulty or convulsive seizures can be identified.

Fahr’s syndrome is rare, with a prevalence of <1 / 1,000,000. Diagnose is based on a compatible CT-scan, with clinical features and exclusion of other medical conditions. Nowadays, treatment is limited to a symptomatic support. The goals of further research are to understand the genetics of this disorder which could lead to an effective method for treating and preventing Fahr’s syndrome.

No significant relationships.

Falls are a significant cause of injury in older adults who are disproportionately at higher risk due to multiple factors such as, mobility issues, co-morbidities and polypharmacy. There are several evidence-based interventions that can be implemented to reduce the risk of – and manage falls.

Assess whether Woodlands Hospital has implemented the standards set by NICE guidelines on the management of Falls in Older People.

Retrospective audit of patients admitted to Woodlands Hospital from 1st June to 1st December 2018. 113 patient records were analysed to determine; was an falls risk assessment completed on admission, did patients ’at risk of falls’ have individualized interventions in place, was a falls risk assessment completed weekly at MDT, following a fall, were patients checked for signs of fracture before moved, was a medical examination completed and were neurological observations completed in patients with observed head injury or where it could not be excluded?

100% of patients had individualised interventions to reduce risk of falls and 97.3% of patients had an assessment of risks completed on admission. 60.3% of patients were checked for signs of fracture. 78.3% of patients had a physical examination within 12 hours. 75% of patients had neurological observations completed.

Risk assessment for falls and individualized interventions for patients at risk of falls were completed at a high standard. There remains scope for improvement of review of risk of falls during weekly MDT, documentation of checking for signs of fractures and neurological examination. The outcomes were relayed to the unit and plans to re-audit in September 2021.

No significant relationships.

University students’ lifestyle has changed dramatically due to the spread of COVID-19. They had to face adaptation to the online learning format, as well as strict and long-term restriction of social contacts.

To trace the dynamics in the main indicators of mental health (depression, anxiety, and stress) and mental wellbeing among students during the first year of the COVID-19 pandemic.

DASS (Lovibond, Lovibond, 1995) and WEMWBS (Tennant et al., 2007) were applied in the research. The study involved 733 students at Russian universities aged from 18 to 23 years (M=20.0; SD=3.23), of which 88.1% were girls. The same design was used in the spring (N=245), in the autumn of 2020 (N=270) and in the winter of 2021 (N=218).

It was found that the indicators for all DASS scales significantly differ (p<0.05) across the three periods. With Post Hoc Scheffe, it was shown that the levels of depression, anxiety and stress in autumn 2020 and winter 2021 were significantly higher than in spring 2020 (p<0.05). The WEMWBS values differ significantly (p<0.05) throughout the periods. The level of mental wellbeing among students in spring 2020 was significantly higher than in autumn 2020 and in winter 2021 (p<0.05).

It was revealed that despite the rather severe restrictions in Russia at the beginning of the pandemic, and relatively mild measures taken afterwards (compared to many countries), the indicators of students’ mental health as well as the level of their mental well-being continued to decline. The reported study was funded by RFBR, project number 20-04-60174.

No significant relationships.

Since the emergence of the term “transsexualism” in the Ninth International Classification of Diseases (ICD-9), disciplines related to mental health have contributed to the perpetuation of stereotypical attitudes towards trans people. Recent years have shown the significant prevalence of mental pathology suffered by this group, and the need for specialized training to improve access to the health system.

The main objectives of this research are: (a) to find and analyse the scientific evidence published which assesses the attitudes of mental health professionals towards the trans community; b) to establish the main variables that modify these attitudes, paying special attention to gender, ideology, sexual orientation and previous training or experience

A systematic review of the literature was conducted following the PRISMA recommendations.

Tendency towards more positive and liberal attitudes among professionals than in the general population.

Higher values for extreme prejudice among those professionals who attributed gender diversity to a psychological, ethico-moral or religious cause.

Association of depathologising practices with belief in the psychosocial nature of diversity, clinical training and interpersonal contact with LGBT people. The following socio-demographic variables were related: being a woman, clinical psychologists, progressive political ideology, professionals who strive to know their own limitations and biases.

More positive attitudes than the general population but still insufficient Specific training in gender diversity and minority issues would be a key element in improving care for transgender people. The attitudes of professionals depend, in part, on the personal characteristics of the therapists.

No significant relationships.

Posttraumatic stress disorder (PTSD) is a psychiatric condition which can be developed following traumatic experience. Treatment guidelines have long considered psychotherapy as a first line treatment. Despite that, PTSD remains an illness with high rates of comorbidity. Therefore, exploring novel therapies is of utmost importance.

Clarifying methylenedioxymethamphetamine (MDMA)-assisted psychotherapy efficacy in symptom relief in people with PTSD. Explaining clinical MDMA mechanism of action. Assessing safety of MDMA clinical use.

PubMed database search, with “MDMA for PTSD” keyword expression. 12 Articles published in the last ten years were selected among the 112 best matches. Reference lists of articles were reviewed to identify additional articles.

Mithoefer et al. (2010) carried out the first controlled clinical study with MDMA-assisted psychotherapy in people with PTSD. Twenty patients with treatment-resistant PTSD were selected. They were given either placebo or two or three sessions of MDMA. 83% of the experimental group no longer met the criteria for PTSD (mean remission lasted 45 months without further MDMA doses) compared with 25% of the placebo group. Further studies were also suggestive of improvements in treatment-resistant PTSD patients undergoing MDMA-assisted psychotherapy. MDMA may increase exposure therapy effectiveness, allowing patients to stay emotionally involved while revisiting past traumas without being overwhelmed by anxiety and fear.

To date, MDMA-assisted psychotherapy studies demonstrated consistently positive results. However, they have been carried out with small groups of individuals. Therefore, larger trials should be conducted to assess MDMA’s efficacy and safety for it to become a licensed medicine.

No significant relationships.

Cognitive functioning and psychological well-being are considered negatively affected by COVID-19. An estimated 15%-40% of COVID-19 patients report disrupted cognitive performance. Higher rates of anxiety, depression and sleep disturbances are also reported post infection.

We examined the profile of cognitive changes in a group of adults with a confirmed COVID-19 diagnosis, compared to those without a COVID-19 diagnosis (cross-sectional between-subjects investigation); and for a subgroup, compared to their pre-COVID-19 cognitive function (longitudinal within-subjects investigation).

One hundred and twenty-one adults (57 with no known history of COVID-19; 64 with confirmed COVID-19; 17/64 with long COVID symptoms) were assessed online for psychological well-being and cognitive function (attention, processing speed, working memory, episodic memory and executive function). Pre-COVID-19 cognitive data were available for 56 of 121 adults (24 adults with a confirmed diagnosis of COVID-19; 22 with no known history of COVID-19) through the MyCognition database.

The COVID-19 group showed reduced processing speed in both cross-sectional and longitudinal investigations, and also showed significant attentional impairment when examined cross-sectionally. Five long COVID symptoms (abdominal pain, chest pain, sore eyes/conjunctivitis, sore throat and vomiting/nausea) were associated with reduced performance in multiple cognitive domains. Higher levels of depression and anxiety were also present in the COVID-19 group but these symptoms were mostly unrelated to cognitive performance.

COVID-19 survivors, especially those with long COVID symptoms, are very likely to experience cognitive disruption. Measures need to be implemented to support their cognitive recovery in addition to the physical recovery.

No significant relationships.

Women with reproductive difficulties often feel stigmatized and isolated. Information concerning their specific experience can help plan psychosocial interventions.

The study aims to analyze reproductive difficulties representations in women with different coping orientations.

Participants: 48 women (aged 24-43) from support groups arranged by the “You Are Not Alone” non-profit organization for women with reproductive issues. Based on the questionnaire “Types of Orientations in Difficult Situation”, participants were divided into three groups: approach coping (N=16), avoidance coping (N=9), ambivalent coping (N=23). Content analysis was conducted based on stories about reproduction difficulties experiences.

Table 1

We identified three types of representation of reproductive difficulties in women: approaching the goal of having a child; avoidance (fear of own death/illness/insanity or not having a child); ambivalent coping (alternating approach/avoidance). Funding: The study was funded by RFBR, project number 20-013-00838.

No significant relationships.

In contemporary context the difficulties of making sense of social ambiguity becomes one of the most important appeals for seeking the psychological help. This grounds the importance of studying the mechanism underlying the quality of mentalization and its individual variations.

The objective of the study was to find empirical relations between the quality of mentalization and its cognitive, emotional and expressive mediating factors.

(1) The Adult Attachment Interview, scored using Social Cognition and Object Relations-Global rating method for mentalization ability. (2) Group embedded figures test. (3) New Tolerance-Intolerance to ambiguity and (4) Toronto alexithymia scale questionnaires. Twenty participants, aged 18-38, looking for psychological consultation, took part in the study.

Correlation analysis suggests positive relation between field-independency and tolerance to ambiguity (r = .47; p < .05). The complexity of representations of the mind positively correlates with the understanding of social causality (r = .92; p < .01). The affective quality of relationships’ representations positively correlates with the ability to emotionally invest into relationships (r = .66; p < .01), and with the understanding of social causality (r = .47; p < .05). The ability of emotional investment into relationships also positively correlates with the understanding of social causality (r = .93; p < .01). There is a negative link between the severity of alexithymia and the presence of long-term relationships with a partner (r = -.53; p < .05).

Mentalization should be understood as a system, with underplaying cognitive, expressive and emotional factors.

No significant relationships.

Although smoking prevalence has been decreasing worldwide, sustained tobacco cessation remains a challenging goal for many smokers. Nicotine replacement therapy (NRT) products remain among the most widespread type of cessation tobacco aids, along with the more recently introduced electronic cigarette, the efficiency of which is still a matter of debate in the public health community.

This study aims to contribute to the ongoing discussion about effective ways of encouraging tobacco cessation and in particular evaluating the role of the two aforementioned tobacco cessation aids with regard to lasting smoking abstinence in real-life settings.

The study is based on the French 2017 Health Barometer, a cross-sectional survey conducted by Santé Publique France. Two distinct outcomes related to tobacco cessation were used: smoking status at 6 months follow-up (yes vs. no) and the duration of smoking abstinence. These two study outcomes were examined respectively among N1 = 2783 and N2 = 1824 participants. All results were weighted based on inclusion probability weights and controlled for propensity scores via overlap weighting (OW), which is appropriate when exposure groups are disparate.

After adjusting on potential confounders, tobacco cessation at 6 months remains significantly associated with e-cigarette use (OR: 1.50 (1.12-1.99)) and e-cigarette use combined with NRT (OR:1.88 (1.15-3.07)). This association did not reach statistical significance in the long-term analysis, nor did the results of NRT use alone in both analyses.

Overall, while electronic cigarette use alone and combined with NRT is associated with an increase in the likelihood of smoking cessation, the long-term effects are probably limited.

No significant relationships.

Agitated behaviors is a common neuropsychiatric symptom (NPS) in dementia, defined as inappropriate verbal, vocal, or motor activity that is not thought to be caused by an unmet need. It is frequently reported as a major problem, that impairs the quality of life for the elderly themselves and for caregivers. There has been increasing interest in the use of sedative antidepressants to treat NPS due to concerns over the safety and efficacy of antipsychotics in this setting.

We aim to review clinical evidence of alternatives to antipsychoticst to manage agitation in dementia.

We conduct a non-systematic review of recent evidence on dementia and agitation, using PubMed/Medline database.

Although non-pharmacological interventions are the first-line treatment for agitation, it is a legitimate target for therapeutic intervention and according to previous guidelines, antipsychotic are among the most used drugs, albeit restricted because of side-effects. A substitution strategy to avoid antipsychotic prescription was highly considered, however there is limited evidence to support the use of antidepressants as a safe and effective alternative for agitation in dementia. Studies compare Mirtazapine, Selective serotonin reuptake inhibitors (SSRIs) and Trazodone and a reduced benefit in mortality is observed. However, citalopram was more effective were more likely outpatients for moderately agitation and Mirtazapine reveals being potentially harmful, in different studies.

Moving forward, a greater understanding of NPS neurobiology, will help to clarify the efficacy of Antedepressants for the treatment of agitation in dementia. Benefits an also the patient and caregiver preference should be kept in mind.

No significant relationships.

Capgras syndrome is a disorder of personal identification characterized by the delusional belief that one or more persons close to the subject have been replaced by physically identical doubles.

To deepen our knowledge of the Capgras syndrome

A case report about a Capgras syndrome.

We report the case of a 46-year-old female patient who was admitted in February 2021 for incoherent speech and behavior disorder against her family members. Three years ago, she started to have hypochondriacal concerns. A week before her admission, she threatened her husband with a knife and she was convinced that her daughters were dead and that they had been replaced by clowns. She had a Capgras delusion with a hallucinatory and interpretative mechanism against her daughters, she reported olfactory and cenesthetic hallucinations. Biological explorations and brain CT were normal. The PANNS scale showed a positive scale of 36, a negative scale of 39, the general psychopathology scale of 53. She had a total score of 30/40 on The Penn emotion recognition test. The patient had difficulty in recognizing low intensity emotions (0 or 1) and 50% of the false responses were for the neutral emotion with responses tending towards anger first and then sadness.

Capgras syndrome remains poorly described in the literature and the hypotheses concerning its origin often oscillate between neuropsychological and psychodynamic. With the recent advances in neuroscience, it would be interesting to deepen its physiopathology in order to place it in a more modern nosological framework.

No significant relationships.

According to the World Health Organization (WHO), the COVID-19 infection became a worldwide devastating health issue starting in December 2019 in China and then gradually was a global pandemic. PTSD after recovery from COVID-19 has been correlated to sleep problems, high anxiety level and depressive manifestations. These sleep problems have their drastic effect on the recovered patients’ quality of life including physical, psychological and social domains.

1-To investigate the sleep in the post Coronavirus -19 period 2-If has an impact on the different items of patients’ quality of life.

1-Socio-demographic characteristics of 500 recovered COVID-19 patients 2-Insomnia Severity index a brief scale evaluating the patient’s insomnia. The ISI evaluates the subjective complaints and results of insomnia as well as the level of dysfunctions from these sleep disturbances 3-Pittsburgh sleep quality index (PSQI):The Pittsburgh Sleep Quality Index (PSQI) is a scale that study the subjective sleep quality and different domains of sleep over a period of 1-month 4-Quality Of Life (QOL) by the SF36 Health Survey is a 36-item -report survey that evaluate eight domains of physical and mental wellbeing ranging from 0 to 100.

The mean score of insomnia severity index was 13.01±4.9.Regarding Pittsburgh sleep quality index ,Sum of seven component scores was 15.37±4.43.Also QOL SF36 showed higher scores of the 8 domains including physical and mental

High score of insomnia and sleep disturbances during the recovery period of COVID-19 infection which affecting the Quality Of Life

No significant relationships.