This essay opens JAS’s special issue on American Studies and the 2024 Election in which contributors explore issues that rose to prominence during the election campaign and the first months of the second Trump administration using a variety of disciplinary lenses and methodologies. It analyses why Trump became only the second president in history to win non-consecutive terms in office and assesses the transformative significance of his early second-term initiatives. At the same time, it advances the guiding premise of the special issue: that the broad objects of study, interdisciplinary approaches, and asynchronous perspectives of American Studies can combine with history and political science to help us better understand Trump’s victory, its causes, and its possible consequences. As demonstrated by It Can’t Happen Here, literature and other cultural outputs can enrich understanding of American history and politics at any given time. As an Area Studies discipline, with a geographical organising principle that compliments the traditional chronological frameworks of English and History, American Studies foregrounds relations between states and regions, and at a national and transnational scale that shape US politics and require consideration to better appreciate the complexity of the country that national aggregates may fail to reveal.