Attempts to cure general paralysis of the insane by infection with Spirochaeta duttoni have been made by Plaut and Steiner (1919), Mühlens and Kirschbaum (1921). Solomon, Berk, Theiler and Clay (1926) have reported upon the employment of Spirillum minus (Spirella morsus-muris) for the same purpose. The experiments referred to met with an encouraging measure of success; for the ultimate results have been comparable with those following therapeutic inoculation with malarial parasites.