Although personality disorders are prevalent conditions and the cause of considerable morbidity, their management remains controversial. The rationale for using psychotropic medication in these conditions is poorly articulated and its evidence base is weak. Nonetheless, psychiatrists continue to prescribe medication for this group as the accompanying paper makes clear. What is less clear is their reason for doing so, as there are frequent co-occurring conditions that might justify the use of medication in their own right. If the field is to progress, there is no substitute for well-designed randomised controlled trials and these ought to be a priority in the setting of any research agenda.