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Global well-posedness and nonlinear stability of a chemotaxis system modelling multiple sclerosis

Published online by Cambridge University Press:  28 July 2021

Laurent Desvillettes
Affiliation:
Université de Paris, Sorbonne Université, CNRS Institut de Mathématiques de Jussieu-Paris Rive Gauche, Paris, France (desvillettes@math.univ-paris-diderot.fr)
Valeria Giunta
Affiliation:
Department of Engineering, University of Palermo, Palermo, Italy (valeria.giunta@unipa.it)
Jeff Morgan
Affiliation:
Department of Mathematics, University of Houston, Houston, Texas 77004, USA (jmorgan@math.uh.edu)
Bao Quoc Tang
Affiliation:
Institute of Mathematics and Scientific Computing, University of Graz, Heinrichstrasse 36, 8010 Graz, Austria (quoc.tang@uni-graz.at, baotangquoc@gmail.com)
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Abstract

We consider a system of reaction–diffusion equations including chemotaxis terms and coming out of the modelling of multiple sclerosis. The global existence of strong solutions to this system in any dimension is proved, and it is also shown that the solution is bounded uniformly in time. Finally, a nonlinear stability result is obtained when the chemotaxis term is not too big. We also perform numerical simulations to show the appearance of Turing patterns when the chemotaxis term is large.

Information

Type
Research Article
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of The Royal Society of Edinburgh
Figure 0

Figure 1. Spatio-temporal evolution of $m$ on the spatial domain $\Omega = [0;\pi ]\times [0;\pi ]$ above the Turing threshold $\chi _c=3.125$. The following parameter values have been fixed: $r=1, \, a=3, \,\varepsilon _0=0.03125, \, \delta =1, \, \beta =1$ and $\chi =3.18.$ The initial condition is a small random perturbation of the homogeneous equilibrium $\bar m = 1$.

Figure 1

Figure 2. Spatio-temporal evolution of $m$ on the spatial domain $\Omega = [0;\pi ]\times [0;\pi ]$ below the Turing threshold $\chi _c$. All parameter values, except $\chi$, are as in Fig. 1, and $\chi =3$. The initial condition is a random perturbation of the homogeneous equilibrium $\bar m = 1$.

Figure 2

Figure 3. Spatio-temporal evolution of $m$ on the spatial domain $\Omega = [0;\pi ]\times [0;\pi ]$ below the Turing threshold $\chi _c$. All parameter values are as in Fig. 2. The initial condition is far from the homogeneous equilibrium $(\bar m, \bar c, \bar d)$.