Surveys of farmers and consultants provide valuable insights into emerging problems and shifts in crop production practices. University researchers and Extension personnel can use this information to direct research and Extension outputs to best meet on-farm needs. A survey of soybean farmers and consultants in the Midsouth region of the United States (Arkansas, Louisiana, Mississippi, southeastern Missouri, and Tennessee) was conducted from October 2024 through March 2025 to understand common weed management practices, problematic weed species, and evolving herbicide resistance. The survey respondents represented those who farm 19% of the total soybean-planted area in the Midsouth, accounting for more than 900,000 hectares. Soybean cultivars that are resistant to glyphosate, glufosinate, and dicamba had the highest adoption rate, accounting for 62% of hectares planted in 2024, with a projected increase to 66% in 2025. Among the survey respondents, S-metolachlor was the most widely used preemergence and postemergence residual herbicide, whereas dicamba was the most common postemergence herbicide used. The most problematic weeds infesting Midsouth soybean fields were Palmer amaranth, prickly sida, barnyardgrass, morningglories, and Italian ryegrass. A significant portion of farmers and consultants suspect that Palmer amaranth has become resistant to synthetic auxins (47%) or glufosinate (52%). Respondents cited the ability to control problematic weed species as the most needed research area and frequently requested research on managing herbicide resistance and alternative cultural practices for weed control. Herbicide resistance is a key concern for farmers, and postemergence herbicide options are increasingly limited, yet there is strong interest in integrated weed management and in adopting new technologies in soybean.