Native pollinator-dependent plants are particularly vulnerable to habitat loss and other disturbances that disrupt pollen transfer. Understanding their reproductive biology is critical for assessing pollination dynamics, seed production, and their vulnerability to environmental change. This study addressed the reproductive strategies and dependence on cross-pollination of three native species in northeastern Patagonia (Larrea divaricata, Schinus johnstonii, and Neltuma flexuosa var. depressa). We applied controlled pollination treatments (cross-, self-, spontaneous-, and open-pollination) and measured the subsequent seed set and seed germination rates. L. divaricata exhibited higher seed set and higher germination capacity when natural pollination was allowed, compared to all manually pollinated treatments. This suggests that repeated visits and multiple pollen donors maximize seed production and seed quality. In S. johnstonii, a polygamous-dioecious species, seed production occurred even under pollinator-exclusion treatments, suggesting a contribution of wind pollination and/or alternative reproductive mechanisms. N. flexuosa var. depressa did not produce fruits under any treatment. These findings reveal contrasting reproductive strategies among Monte shrub species, highlighting that reproductive success may depend on different pollen-transfer pathways, from strong reliance on pollinator activity to potential airborne pollen contributions. Understanding these strategies is essential for conserving pollination processes, seed production, and the long-term resilience of arid Patagonian ecosystems.