Wild parsnip (Pastinaca sativa L.) is an invasive perennial that invades tallgrass prairies. The presence of native forbs prevents broadcast applications of herbicides that control P. sativa, as desirable native forbs are sensitive to herbicides used. Florpyrauxifen-benzyl may control P. sativa at low rates. This in combination with native forbs’ tolerance to florpyrauxifen-benzyl may allow broadcast applications. Research was conducted to evaluate the effectiveness of florpyrauxifen-benzyl applications on P. sativa and to determine what rate eliminates 95% of P. sativa and whether native forbs tolerate broadcast applications. Initial experiments found P. sativa was sensitive to florpyrauxifen-benzyl at rates as low as 3.7 g ai ha−1 at 60 d after treatment. Further experiments found 1.7 g ha−1 reduced P. sativa populations by 95%. Concurrent studies in P. sativa invaded tallgrass prairies confirmed florpyrauxifen-benzyl alone (14.7 g ha−1) reduced density of P. sativa plants by >85% at 1 yr after treatment (1 YAT) and that reduced rate (11 g ha−1) mixed with imazapic (35 g ae ha−1) was equally effective. These treatments reduced native forb cover 1 YAT (up to 25% compared with nontreated controls); however, the impact varied among forb species. Of the eight common native forbs, three were reduced by florpyrauxifen-benzyl alone 1 YAT. Reductions in cover in two of these species sensitive to the higher rate of florpyrauxifen-benzyl were not observed 1 YAT when reduced rates of florpyrauxifen-benzyl combined with imazapic were applied. Florpyrauxifen-benzyl was effective at controlling P. sativa at low rates (0.9 to 3.7 g ha−1), and while some native forbs were tolerant to spring broadcast applications, others were sensitive to higher rates (11 to 14.7 g ha−1). Further research is needed to quantify whether rates that provide acceptable P. sativa control are safe to native forbs in infested tallgrass prairies.