Armed conflicts produce profound and lasting damage to the mental health of individuals and societies. Meta-analyses document a post-traumatic stress disorder prevalence of 23–30% among war-exposed civilians, yet the field lacks an integrative account connecting symptom formation to the relational, collective, intergenerational and structural dimensions of trauma. This article develops an integrative theoretical framework for the psychological consequences of war, demonstrates its clinical value for practitioners and situates this synthesis within a social psychiatry perspective addressing structural determinants of mental health in conflict settings. A narrative theoretical review and conceptual integration was employed. Five psychotherapy frameworks were selected: Jung’s collective unconscious and shadow; Berne and Steiner’s life scripts and emotional literacy; Erskine’s relational needs model and Perls’s unfinished business approach. These were examined alongside meta-analytic, neurobiological, epigenetic and social determinants evidence. Two composite clinical vignettes illustrate the framework’s application. Literature was identified through systematic searches of PubMed, PsycINFO and Web of Science (2000–2025). The review indicates that war generates individual psychopathology while disrupting relational and collective psychological organization. Epigenetic evidence demonstrates transgenerational transmission via hypothalamic–pituitary–adrenal (HPA) axis programming. Social determinants – deprivation, displacement, gender and health system collapse – differentially amplify psychological harm across populations. War produces lasting transformations across individual, relational and collective functioning, with mental health burdens concentrated among the most disadvantaged populations. The integrative framework offers clinicians a grounded lens for case formulation, identifies structural determinants of vulnerability and argues that peace and equity are prerequisites for psychological integrity and population mental health.