We want to compute generic
$\mathrm {Ext}$-spaces of twisted polynomial functors in relation to the
$\mathrm {Ext}$-spaces of the untwisted ones. We are able to conjecture a direct formula that is suggestively similar to the one known for ungraded functors. Thanks to the study of a spectral sequence, we get to a total computation in low degrees, with remarkable consequences at the level of generic cohomology. Moreover, a partial computation in all degrees proves the inclusion of a big direct summand and the existence of a suggestive universal class.