Although it typically makes up only 1% (or less) of the mass of the interstellar medium (ISM) in a galaxy, interstellar dust is absolutely critical to ISM physics. Dust is also the repository of a large fraction of the heavy elements, and thus is central to understanding the cosmic history of elemental enrichment in the universe. With knowledge of the dust-gas relationship, dust can also be tracer of gas, spanning the atomic and molecular phases of the ISM. I will review recent efforts to understand the relationship between dust and gas in nearby galaxies, particularly as a function of ISM phase and metallicity. I will also describe exciting new work using JWST observations of the mid-infrared emission from small carbonaceous dust grains (polycyclic aromatic hydrocarbons) as a tracer of gas column in nearby galaxies.

With steadily mounting evidence that points to a cosmic origin of terrestrial life, a cultural barrier prevails against admitting that such a connection exists. Astronomy continues to reveal the presence of organic molecules and organic dust on a huge cosmic scale, amounting to a third of interstellar carbon tied up in this form. Just as the overwhelming bulk of organics on Earth stored over geological timescales are derived from the degradation of living cells, so it seems likely that interstellar organics in large measure also derive from biology. As we enter a new decade – the year 2010 – a clear pronouncement of our likely alien ancestry and of the existence of extraterrestrial life on a cosmic scale would seem to be overdue.

The interstellar absorption band centred on 2175 Å that is conventionally attributed to monodisperse graphite spheres of radii 0.02 μm is more plausibly explained as arising from biologically derived aromatic molecules. On the basis of panspermia models, interstellar dust includes a substantial fraction of biomaterial in various stages of degradation. We have modeled such an ensemble of degraded biomaterial with laboratory spectroscopy of algae, grass pigments, bituminous coal and anthracite. The average ulrtraviolet absorption profile for these materials is centred at 2175 Å with a full width at half maximum of 250 Å, in precise agreement with the interstellar extinction observations. Mid-infrared spectra also display general concordance with the unidentified interstellar absorption features found in a wide variety of astronomoical sources.

The Herschel and Planck satellites have started imaging the sky at far-IR to mm wavelengths with an unprecedented combination of sky and spectral coverage, angular resolution, and sensitivity, thus opening the last window of the electromagnetic spectrum on the Galaxy. Dedicated observing programs on Herschel and the Planck all-sky survey will provide the first complete view at cold dust across the Galaxy, opening new perspectives on the structure and dynamical evolution of the Milky Way relevant to Gaia. The analysis and modelling of these observations will contribute to our understanding of two key questions: how do stars form from interstellar matter? how are the interstellar medium and the magnetic field dynamically coupled? The comparison with Gaia observations will contribute to build a 3D model of the Galactic extinction taking into account dust evolution between ISM components

The Solar System passes within 5 pc of star-forming nebulae every ∼50–100 million years, a distance which can be bridged by protected micro-organisms ejected from the Earth by impacts. Such encounters disturb the Oort cloud, and induce episodes of bombardment of the Earth and the ejection of microbiota from its surface. Star-forming regions within the nebulae encountered may thus be seeded by significant numbers of microorganisms. Propagation of life throughout the Galactic habitable zone ‘goes critical’ provided that, in a typical molecular cloud, there are at least 1.1 habitable planets with impact environments similar to that of the Earth. Dissemination of microbiota proceeds most rapidly through the molecular ring of the Galaxy.

The question ‘Are supernovae important sources of dust?’ is a contentious one. Observations with the Infrared Astronomical Satellite (IRAS) and the Infrared Space Observatory (ISO) only detected very small amounts of hot dust in supernova remnants. Here, we review observations of two young Galactic remnants with the Submillimetre Common User Bolometer Array (SCUBA), which imply that large quantities of dust are produced by supernovae. The association of dust with the Cassiopeia A remnant is in question owing to the contamination of foreground material. In this paper, we compare the emission from cold dust with CO emission towards Kepler’s supernova remnant. We detect very little CO at the location of the submillimetre peaks. A comparison of masses from the CO and the dust clouds are made, and we estimate the 3σ upper limit on the gas-to-dust ratios to be in the range 20–60. These results suggest that we cannot yet rule out freshly-formed or swept-up circumstellar dust in Kepler’s supernova remnant.