Let
$\mathcal{M}$ be a von Neumann algebra equipped with a normal semifinite faithful trace
$\tau$, and let
$A$ be an expansive dilation on
$\mathbb{R}^d$. In this paper, the authors first investigate a class of local operator-valued anisotropic Hardy spaces, denoted by
$\mathbf{h}_p^A(\mathbb{R}^d,\mathcal{M})$, and identify their dual spaces. This further develops the seminal work of T. Mei [MR2327840: Mem. Amer. Math. Soc., (2007)]. In addition, we also show that
$\mathbf{h}_1^A(\mathbb{R}^d,\mathcal{M})$ and
$\mathrm{bmo}_A(\mathbb{R}^d,\mathcal{M})$ serve as natural endpoint spaces for the noncommutative
$L_p$-spaces
$L_p(L_{\infty}(\mathbb{R}^d)\overline{\otimes}\mathcal{M})$, and these endpoint spaces are then used to establish the
$L_p$-estimates for certain operators via interpolation. Finally, as applications, an atomic decomposition for local Hardy spaces and Hardy–Lebesgue estimates for a local class of noncommutative Calderón–Zygmund operators are also established. To the best of our knowledge, these results are new in the operator-valued setting even for diagonal anisotropic dilations (when
$A:=\mathrm{diag}(\lambda_1, \lambda_2, \ldots, \lambda_d)$ with
$|\lambda_j| \gt 1$,
$j=1,2,\ldots,d$).