Ion homeostasis is the process by which plants maintain the right balance of mineral and non-mineral ions inside their cells. This regulation helps plants survive challenges such as drought, salty soils and changing nutrient levels while supporting healthy growth and development. The enormous advances in our understanding of plant membrane transport at a molecular level now provide a mechanistic basis for understanding plant nutrition at cellular and whole plant levels. And in combination with quantitative mathematical analysis, fundamentally new insights into homeostatic processes are obtained.