Objectives/Goals: Relevant publications serve as a comprehensive longitudinal data source that reflects the priorities, partnerships, and training a CTSA program supports. A content analysis of the publications was conducted to identify the specific areas where our CTSA program has the most impact and provides the most support. Methods/Study Population: A content and bibliometric analysis was conducted for the Frontiers CTSI. Articles were identified by searching for all current and previous grant numbers in Google Scholar and PubMed and identifying relevant publications through ERACommons. We utilized Covidence to facilitate the screening and coding process. Articles were included if they were published after the grant initiation (2011), attributed support to the grant, and were peer reviewed. Articles were then double coded for variables such as member institutions, CTSA collaboration, awardee type, disease area, and study type, etc. Bibliometric outcomes were retrieved from NIH iCite and Web of Science. Descriptives, t-test, and linear models were used to assess associations. Results/Anticipated Results: A total of 941 publications from 2011 to April 2024 were included for analysis. When examining collaboration between Frontiers and other CTSA hubs, 40% of publications had authorship representing multiple hubs, with 95% of the CTSA hubs represented. Most publications were directly supported by Frontiers: 44% from TL1 & KL2 scholars and 56% from past pilot awardees. The primary disease area supported was neurology, with 60% of publications describing T2: clinical research studies. The main output of interest, the NIH’s relative citation ratio (RCR), has an average of 1.64 over 13 years. Publications with collaborations between Frontiers and another CTSA hub were associated with higher RCRs. Discussion/Significance of Impact: This analysis provides us with a snapshot of frontiers CTSI’s activities and impact while also highlighting areas where our support can be strengthened. Next, we plan to incorporate altmetric data to create a more holistic view of our CTSA’s impact and collaborations.

Objectives/Goals: The goal of the NCATS CTSA Collaborative and Innovative Acceleration (CCIA) Award Initiative is to advance clinical and translational science through the collaboration, dissemination, and implementation of innovative solutions that have long-term, real-world impact. Methods/Study Population: To evaluate the real-world impacts of the CCIA Initiative, the Translational Science Benefit Model (TSBM) framework was used to create TSBM Impact Profiles for 55 CCIA awards issued between 2016 and 2022 using a secure large-language model (HHS-NIH GPT-5). Profiles were generated using data from final research performance progress reports (RPPRs) or, when those were unavailable, the most recent RPPRs in ERACommons. To guard against inaccuracies, 10% of AI-generated case studies were randomly selected and independently validated by subject matter experts. Descriptive statistics were used to summarize overall CCIA impacts. Results/Anticipated Results: A total of 49 fRPPR and 6 RPPRs were analyzed. TSBM Impact Profiles were efficiently, securely, and accurately generated using AI. Analysis showed that the CCIAs produced innovative solutions impacting all four TSBM domains and each of the nine subcategories. Evidence linked the CCIAs to 28 of the 30 TSBM benefits. The CCIAs had the greatest translational science impact in the Procedure & Guidelines category of the Clinical & Medical Benefits domain; most observed benefits were associated with improvements to Clinical Care Guidelines (25 awards), followed by Therapeutic- (23 awards) and Investigative Procedures (19 awards). Discussion/Significance of Impact: Analysis using the TSBM framework suggests that the CCIA Initiative has had wide-ranging, real-world impacts, indicative of the effective development and dissemination of innovative solutions beyond traditional scientific outputs.

Objectives/Goals: Addressing institutional barriers for research using multicriteria ranking focusing on a top institutional barrier, difficulties in finding available resources and services to support research, using qualitative analysis technique by identifying, summarizing barriers contributing to this barrier, and recommending improvement strategies. Methods/Study Population: On an annual basis, we surveyed users who utilized CTSI services and resources regarding their level of satisfaction and the degree of various institutional barrier affecting their ability to conduct clinical and translational research. Using Multicriteria Ranking, the top barrier in 2021 and 2022 was difficulties in finding available resources and services to support research. We contacted each one of the consenting respondents who identified it as a top institutional barrier (n = 26) for interview. Out of 26, 10 individuals consented to be interviewed. We conducted one-on-one interviews following the individualized semi-structured interview methodology. We conducted thematic qualitative analysis to find common barriers and suggested mitigation strategies. Results/Anticipated Results: Using thematic analysis, six main themes were identified that contributed to difficulties in finding available resources and services to support research: Complexity of access and multi-institutional organizational structure, Finding knowledgeable assistance, Time delays, CTSA Hub operational difficulties, Non-CTSA Hub researcher difficulties, and Non-physician researcher difficulties. Once we synthesized and analyzed the themes, we reviewed the data and searched for suggestions researchers made. We identified and linked mitigations to each relevant theme. The mitigations ranged from implementation of concierge and tiered structured costing systems, as well as conducting follow-on process improvement project, and enhancing education. Discussion/Significance of Impact: Implementation of the thematically driven mitigation will increase awareness of CTSI programs and services and reduce a barrier to research, which will increase the speed of research. The use of our approach fosters continuous improvement environment by using mitigation that are based on users’ input, using a structured data-driven approach.

Objectives/Goals: It is currently recommended that primary care providers screen at-risk populations for fatty liver disease using transient elastography (TE) or magnetic resonance elastography (MRE), but the availability of these tests is unknown. Our aim was to identify the geographic availability of TE and MRE units in the Upper Midwest. Methods/Study Population: Using public data from each test’s manufacturer’s website, we identified and mapped the number of TE and MRE units in each county in the Upper Midwest (Minnesota, Wisconsin, and Iowa). Results/Anticipated Results: In Figure 1, we present a map of Minnesota, Wisconsin, and Iowa. Figure 1 displays the density of TE and MRE units in MN, WI, and IA. It can be seen that the majority of counties in these three states do not have any TE or MRE units. In Table 1, we present the percent of counties in MN, WI, and IA without access to a TE or MRE unit. The vast majority of counties in these three states do not have any TE (89% of counties in MN, 81% of counties in WI, and 96% of counties in IA) or MRE (90% of counties in MN, 94% of counties in WI, and 98% of counties in IA) units. Discussion/Significance of Impact: There is limited access to TE and MRE in the Upper Midwest. This highlights the need for alternative technology to help primary care providers screen for fatty liver disease in practices where TE and MRE are not available.

Objectives/Goals: Advance translational understanding of how families with young children from low SES backgrounds engage with music and how these experiences shape interest in music enrichment programs. By identifying family perceptions and barriers, this work will inform the design of responsive music interventions to promote developmental outcomes. Methods/Study Population: This is a qualitative study of semi-structured interviews. Families had at least one child who was ≤ 2-years old and an income which qualified for the Women, Infants, and Children’s (WIC) program. Exclusion criteria included children (≤ 2-years old) with chronic health diagnosis (e.g., cerebral palsy). Audio recordings were transcribed and coded using the inductive approach of thematic analysis. N = 15 included in the final analysis. The sample consisted of primarily black (53%) and multi-race (20%) families who reported an annual income below the 2023 poverty threshold for the number of family members living in the home (73%). Participating parents were mothers (94%), single (73%), and had a high school education or below (87%). Results/Anticipated Results: The home music environment: Parents’ own musical background influences decisions on music they select for their children. Parents prefer children’s songs that sound like the music they prefer to listen to (e.g., pop, hip-hop). Parent–child music interactions mostly include listening to and watching music shows vs. singing together. Parent interest/perception of community music programs: Parents have interest in community music programs and are interested in social and educational benefits to their child. Parent perceived barriers: Parents were not aware of music programs in their community. Social barriers include irregular work schedules, co-parenting, transportation, and balancing the demands of multiple children. Discussion/Significance of Impact: Understanding how families from low SES backgrounds engage with and access community-based music programs will inform equitable and scalable strategies to promote early developmental enrichment through music, bridging research and community impact.

Objectives/Goals: Parenting programs overlook the needs of Latina mothers affected by intimate partner violence (IPV). To address this, we aim to adapt the Attachment and Biobehavioral Catch-up (ABC) parenting program. Objective: to understand core parenting challenges and strengths, identify implementation needs, and deliver a contextually responsive protocol. Methods/Study Population: Guided by the ADAPT-ITT framework, we are conducting semi-structured interviews with Latina mothers (n = 12–15) and service providers (n = 5-10) to inform the adaptation of ABC while maintaining its core components (10 dyadic sessions focused on following the child’s lead, nurturing children when distressed, and avoiding frightening behaviors). To date, we have interviewed four mothers in Spanish. Two bilingual coders are conducting the thematic analysis using Nvivo. The results presented here are preliminary, based on 80% inter-rater reliability, and derive from transcript review and interviewer memos; final themes will be confirmed through the planned coding process Results/Anticipated Results: We identified the following themes: parenting challenges: persistent safety worries after IPV; heavy caregiving responsibilities with limited time and money; custody/visitation disrupting children’s routine; immigration related stress and co-parent conflict; and symptoms of depression/anxiety. Parenting strengths include a strong commitment to protection, existing routines, and faith/community support. Anticipated adaptations include acknowledging mothers’ protective strengths while integrating brief, accessible content that normalizes stress responses and offers practical co-regulation tools (e.g., grounding breathing exercises) to strengthen parent–child connection. Discussion/Significance of Impact: Early insights suggest that pairing ABC with content that honors mothers’ protective strengths, normalizes stress responses, and offers accessible co-regulation tools could fill a critical gap in contextually responsive support for Latino families, potentially strengthening parent–child relationships and increasing service access.

Objectives/Goals: Incorporating community voice ensures that research meets real world needs and enhances community trust and engagement. The objective of this program is to train community members on research to become community scientists and strengthen their role as partners in research, advancing the translation of discoveries into community practice. Methods/Study Population: Based on the University of Florida Citizen Scientist model, Mayo Clinic launched a Community Scientist (CS) program in 2021 as a one-day event. It expanded to a 4-week program in 2022, an 8-week program with a 6-week experiential assignment in 2023−2024 and added asynchronous training in 2025. The CS curriculum integrates didactic and experiential assignments with pre/post evaluations implemented in 2023 and expanded in 2024 to include post evaluations for the 6-week experiential assignment. Participants represented three Mayo Clinic regions (Arizona, Florida, Midwest), reflecting different geographies and backgrounds. Evaluations assessed participants’ knowledge, confidence, and engagement in multiple topics such as genomics, ethics, biobanking, and researcher–community collaboration. Results/Anticipated Results: 30 CS participants completed training once evaluations were implemented, and the CS participants’ familiarity with the role of a community scientist increased from 20% to 90%. Understanding of genomics and biobanking increased from <20% to 80% and knowledge of research ethics and IRB processes increased from 30% to 75%. Participants agreed that the experiential assignment deepened their understanding (82%), confidence (80%), and ability (70%) to partner with researchers. High satisfaction scores (89%) from the CS participants supported the program’s value and 100% noted readiness to engage as a CS in research. Overall results demonstrate the program’s scalability and effectiveness while also noting the need for consistent evaluation for program improvement. Discussion/Significance of Impact: The CS program empowers communities with knowledge and confidence to engage with research teams, advocate locally and partner with investigators. Strong gains and consistent growth across domains highlight the CS program’s potential as a scalable model for meaningful community engagement in research.

Objectives/Goals: To demonstrate how small grant funding (up to $5,000) for the dissemination of community-academic partnered research findings can accelerate translation by delivering relevant, actionable information to communities, supporting ongoing partnerships, and catalyzing future research and funding opportunities. Methods/Study Population: Promoting Academic and Community Engagement (PACE) dissemination grants were awarded through a competitive funding mechanism. Over four funding cycles, the program received 25 submissions and funded 15 projects, awarding a total of $75,000 to projects across Michigan. The grants supported established community-academic partnerships to share their community-engaged research (CEnR) findings with communities of interest. Dissemination was defined as returning research results to nonacademic audiences to accelerate translation. Traditional scholarly dissemination (e.g., publications or conferences) was not eligible. All awardees submitted final reports detailing their dissemination strategies, impacts, and outcomes. Results/Anticipated Results: The PACE grants were designed to accelerate the translation of research into communities through focused, community-facing dissemination. Across four funding cycles, 15 funded projects reported employing broad dissemination strategies, including community forums, multimedia campaigns, artistic expression, and local events. Final reports described increased community awareness, enhanced trust and engagement, and momentum for follow-up collaborations and funding proposals. The poster will present key findings and selected examples to illustrate how modest, targeted investments can lead to measurable impacts in research translation at the community level. Discussion/Significance of Impact: This poster will highlight how CTSAs can implement scalable, low-cost funding mechanisms to support community dissemination of research. Programs like PACE foster academic-community engagement, accelerate translation of findings, and offer a replicable model for supporting community-centered translational science.

Objectives/Goals: To identify barriers to HPV vaccination and cervical cancer screening among Black and Hispanic women in Northwest Louisiana as a first step toward developing community-driven strategies to eliminate cervical cancer in the state. Methods/Study Population: This cross-sectional study includes women aged 18–45 years who identify as Black or Hispanic. Participants are recruited through multiple methods, including community health fairs, churches, clinics, and snowball recruitment through peer referrals. Surveys are administered via REDCap in English and Spanish. We plan to enroll 260 women; this preliminary analysis includes 70. Structured surveys collect data on HPV awareness, provider offer, vaccination history, and cervical cancer screening. Sociodemographic characteristics and access factors are analyzed to describe prevention gaps. The study was approved by the LSUHS IRB (#00002755). Results/Anticipated Results: Preliminary findings reveal major prevention gaps. Nearly half (46%) had never heard of HPV, and 43% had never heard of the HPV vaccine. Among those aware, 59% reported never being offered the vaccine, and 76% had never received it. While 69% believed the HPV vaccine prevents cervical cancer and 21% said it prevents genital warts, nearly half (49%) were unsure about its effectiveness. Among mothers, 31% were willing to vaccinate their children, and 7% had already done so. For cervical cancer screening, 86% had a Pap test; however, 20% were not up to date. Among those screened for cervical cancer, most reported their last test was over three years ago. Participants were on average 33.2 years old (SD = 8.1), predominantly Black (74%) or Hispanic (26%), with 57% single, 66% employed full-time, and 72% insured. Discussion/Significance of Impact: Eliminating cervical cancer in Louisiana requires equitable access to HPV vaccination and screening. This study identifies important prevention gaps in minority women and demonstrates how community-based approaches can inform targeted interventions to achieve cervical cancer elimination.

Objectives/Goals: This poster will provide key insights from a landscape analysis examining resources for community-engaged research (CEnR) across three University of Michigan (U-M) campuses. Highlights will include notable gaps and limitations and how the analysis will inform future U-M CTSA CE programming to support CEnR efforts at U-M. Methods/Study Population: A landscape analysis of CE resources available at U-M was conducted as part of a multipronged approach to inform CTSA CE services. Through a comprehensive review of U-M websites, the analysis identified 83 CEnR programs and services across Ann Arbor, Flint, and Dearborn campuses of U-M. Programs were mapped by audience (faculty, staff, students, and community partners), topic, and service type. Assessment of distribution, website clarity, and ease of navigation further illuminated opportunities to improve support and efficiency to better meet the needs of those engaged in CEnR at U-M. Results/Anticipated Results: The landscape analysis identified 83 CEnR-related programs and services at U-M, most concentrated in Ann Arbor, and with the highest concentration in a few units. Data analysis services, resources for sustaining and sharing work, and structured grant feedback were relatively rare. Availability of funding for community-focused initiatives was infrequent and generally under $10,000. Over 70% of resources were available to faculty or students, 18% were available to the community, and just under 13% were open to staff. Findings will be used by MICHR to identify opportunities for future CE initiatives. Discussion/Significance of Impact: The poster outlines a landscape analysis framework and process that can be replicated by other CTSAs to assess institutional CEnR resources. This approach helps identify gaps and develop supports that meet the evolving needs of research teams and the community partners they collaborate with.

Objectives/Goals: Latinas experience more severe menopause symptoms compared to non-Hispanic white women, yet they are less likely to use menopause hormone therapy (MHT), often due to misinformation. This study was conducted to understand Latinas’ information needs and communication preferences regarding menopause and MHT. Methods/Study Population: A qualitative descriptive study was conducted with 22 self-reported Latinas/Hispanic women between 40 and 60 years (M = 47.7 ± 4.6 years), living or working in Southeast Texas. Six focus groups were conducted in English (2 in-person and 3 virtual) and Spanish (1 virtual), audio recorded and transcribed in English. Data were analyzed using emergent thematic analysis. Women completed an adapted version of The Menopause Society’s Menopause Health Questionnaire (English or Spanish). Results/Anticipated Results: Three informational needs emerged among Latinas: 1) Increase preparedness about menopausal expectations (i.e., physiology, symptoms/trajectory, treatment options); 2) MHT use and related risks; and 3) menopause information provided much earlier than symptoms appear, “the earlier the better.” Three communication preferences emerged: 1) Latinas obtain menopause information from midlife female family members (excluding mothers), friends and coworkers, internet searches, social media, magazines, and gynecologists; 2) prefer to obtain information from primary care providers, women’s health practitioners, and reputable organizations; and 3) prefer communication be provided via brochures, videos (i.e., waiting rooms), workshops/seminars, reputable websites, social media, and TV commercials. Discussion/Significance of Impact: Latinas’ express knowledge gaps about menopause and MHT, despite publicly available information. Providers and scientific organizations should better disseminate evidence-based information, in multiple formats, to improve menopause preparedness. Further research with larger Latina groups is needed.

Objectives/Goals: Heart disease is a leading cause of death in Alabama. Non-Hispanic Black (NHB) women demonstrate greater arterial stiffness than Non-Hispanic White (NHW) women. We explored whether cardiorespiratory fitness (VO2max) accounts for population differences in arterial stiffness among postmenopausal women. Methods/Study Population: We analyzed data from 57 postmenopausal women (65% NHB; age: 62±8 years; BMI: 28±4 kg/m2; blood pressure: 136±17/80±9 mmHg). VO2max was measured using maximal treadmill testing (Modified Bruce Protocol) and arterial stiffness (pulse wave velocity, PWV) via SphygmoCor XCEL. We used bias-corrected bootstrapped mediation models (5,000 resamples) to estimate the indirect effect of ancestry on PWV via VO2max, adjusting for age, body mass index, lived experience, adverse childhood exposures, and neighborhood deprivation. Given the small sample size, these analyses are exploratory. Results/Anticipated Results: NHB women had significantly lower VO2max than NHW women (18.0±3.7 vs. 23.8±4.5 mL•kg−1•min−1). VO2max was inversely associated with PWV (B = -0.10, SE = 0.04, p = 0.02, 95% CI = −0.19 to −0.01). After adjustment, ancestry was not directly associated with PWV. Neighborhood deprivation (B = 0.16, SE = 0.07, p = 0.02, 95% CI = 0.03 to 0.29) and lived experience (B = 0.10, SE = 0.04, p = 0.03, 95% CI = 0.01 to 0.19) were associated with higher PWV, even after adjusting for VO2max and risk factors. In bootstrapped mediation models, the indirect effect of ancestry on PWV through VO2max was significant (B = 0.35, SE = 0.19, 95% BCa CI = 0.03 to 0.78), consistent with partial mediation. Discussion/Significance of Impact: Cardiorespiratory fitness appears to partly account for population differences in arterial stiffness, but this cross-sectional analysis with a modest sample is exploratory. Targeting both fitness and upstream socioeconomic factors may be needed to reduce differences in women’s vascular health.

Objectives/Goals: Texas Southern University (TSU), a low-resourced HBCU and one of the largest in the USA, without an affiliated hospital, clinic network, or patient population, established a community-focused clinical research site to educate, recruit, and expand research participation, especially among those with unmet health needs. Methods/Study Population: The implementation process involved strategic planning in five key areas as below: * Collaboration: Partnered with mentor site to align site capabilities with industry standards * Capacity Building: EstablishCTMS, eReg, eSource, and REDCap workflow * Workforce Training: Hired and strengthened research personnel expertise through training, certification, and mentorship * Community Engagement: Enhanced trusted relationships with community members, key stakeholders, and advisory board members * Infrastructure Development: Defined site capabilities: regulatory processes, data management, IRB optimization, budgeting, contract management, and prospective study feasibility assessments. Developed standard operating procedures and clinical research registry for site readiness Results/Anticipated Results: A first of its kind Community-Focused Clinical Research Site in a low-resourced HBCU without an affiliated hospital, clinic network, or patient population was successfully established at TSU with mentorship by the University of Texas Medical Branch Galveston, PhRMA Foundation EQBMED, and RCMI Coordinating Center. A registry for potential research participants was successfully implemented in May 2025. Since its inception, 160 community members have indicated interest in clinical research registry participation. 56 community members are fully enrolled in the registry. Key challenges included bridging feasibility gaps at TSU, navigating the development of new clinical research infrastructure, and managing regulatory and contracting approval timeline. Discussion/Significance of Impact: Establishing a clinical research site in a low-resourced HBCU without an affiliated hospital requires cross-disciplinary collaboration and intentional community engagement. TSU’s approach offers a replicable model for integrating clinical research to expand access to community member especially among those with unmet health needs.

Objectives/Goals: To describe the early implementation of the FDA-approved Shield blood-based colorectal cancer screening test using a mobile health unit serving rural Louisiana, assessing population reach and acceptability of the test. Methods/Study Population: This is a secondary analysis of implementation data collected by the Partners in Wellness (PIW) Mobile Health Unit between February and August 2025. The mobile unit includes a designated blood-draw space where specimens were collected by a trained phlebotomist or a registered nurse following standardized procedures. Adults aged ≥45 years were eligible. De-identified demographic information and Shield test results were analyzed descriptively. All individuals with positive results were referred for colonoscopy, and those with inconclusive results were offered Cologuard stool-based testing. One participant declined the stool-based testing. Results/Anticipated Results: A total of 77 individuals completed Shield testing the mean age was 59.5 years (range 30.6–89.9). Most were female (98.7%), representing 31 rural cities and one urban city. Racial/ethnic distribution included African American (33), White (26), Hispanic/Latino (16), Pacific Islander (5), and Asian (1) participants. Test outcomes were negative (87%), positive (10%), and inconclusive (3%). All positive participants were referred for colonoscopy. Among inconclusive cases, two were offered stool-based testing and one declined. Implementation was well accepted and demonstrated operational feasibility within mobile health services. Discussion/Significance of Impact: Integrating an FDA-approved blood-based colorectal cancer screening test into a mobile health program demonstrates a scalable and innovative strategy to reach medically underserved populations. This model can transform rural screening delivery and advance cancer health equity.

Objectives/Goals: This study aims to understand the relationship of intrapartum depression with gestational weight gain and postpartum weight retention, given the inconsistent findings in prior research. These findings could inform intervention strategies to prevent maternal and fetal obstetric consequences as well as future maternal cardiometabolic sequelae. Methods/Study Population: We analyzed data from a randomized controlled trial at a tertiary care center. Participants had singleton pregnancies <15 weeks gestational age and BMI >=25; those with diabetes, severe hypertension, history of preterm birth, psychiatric illness, or substance use disorders were excluded. Baseline demographic and obstetric characteristics were obtained. Depression was measured using a modified Edenborough Postnatal Depression Scale (EDPS). Maternal weights were a combination of measured clinical weights and self-reported weights. These were used in conjunction with CDC guidelines to determine adequate, excessive, or inadequate gestational weight gain at 37 weeks as well as to assess weight retention at 6 months postpartum. Regression analyses will be conducted in Stata18. Results/Anticipated Results: There were 375 participants enrolled in the study. Of these participants, 54.7% were White, 29.9% Black, 5.9% Asian, and 9.6% multi-racial/other; 9.1% were of Hispanic ethnicity. Mean age was 32.8 (SD: 5.0), and mean baseline weight was 198.8 lbs (SD: 39.9). Early pregnancy (<15 weeks gestation) BMI distribution was 35.5% 25-29.9 kg/m2, 48.0% 30-39.9 kg/m2, and 16.5% >= 40. Mean baseline EDPS score was 6.1. Planned analyses will evaluate the associations between baseline EDPS scores and (1) gestational weight gain at 37 weeks and (2) postpartum weight retention at 6 months. We hypothesize that higher baseline EPDS values will be associated with increased gestational weight gain and increased postpartum weight retention. Discussion/Significance of Impact: Excessive weight gain in pregnancy increases risk for complications such as preeclampsia, gestational diabetes mellitus, and need for a Caesarian section. Postpartum weight retention increases risk for future cardiometabolic disease. Understanding risk factors for excess weight gain/retention will inform targeted screening and interventions.

Objectives/Goals: Integrating lived experiences of people like patients and caregivers across translational research increases responsivity to local need and likelihood of meaningful results. The Community Health Consultant (CHC) Program is a dynamic, formalized source of lived experience advisors for the Institute of Clinical and Translational Sciences (ICTS). Methods/Study Population: Established in 2023, the CHC Program comprises: 1) ongoing recruitment of individuals committed to sharing their lived experiences and perspectives with researchers; 2) creation of profiles which detail an individual’s neighborhood involvement, lived experiences with health and social conditions, and interest in types of advisor activities; 3) matchmaking individuals with relevant lived experiences to community studios, boards, and community grant review processes; 4) a formalized compensation structure which prioritizes efficiently compensating consultants at a rate that demonstrates the value that lived experiences brings to research processes; and 5) consistent feedback loops with the CHC Program as a whole as well as with individual consultants. Results/Anticipated Results: To date, 152 individuals with wide-ranging backgrounds have joined as lived experience advisors to ICTS research. A sample of their collective individualities: * Chris is a community health worker in East Saint Louis. He wanted to be a liaison to the areas he says researchers do not go. “Researchers need to listen to people like me,” he says, “the urban community feels like it’s lost its voice.” * Terry is a mayor in north St. Louis. He says if a researcher is focused on a particular group, they should get “real feedback on how we feel these things benefit us or not benefit us.” * Melvia is an active senior citizen. She says, “The connection to the community is a wealth of information.” In 12 months, activities have included community studios (46), grant review (32), advisory committee linkages (6), and faculty lunch meetings (3). Discussion/Significance of Impact: A dynamic, formalized source of lived experience advisors is critical for mobilizing engagement activities to support ICTS researchers. A community engagement program acts as a natural coordinating hub, building and maintaining individual relationships while matchmaking and providing warm handoffs for lived experience linkages.

Objectives/Goals: Increase enrollment of populations reluctant to participate in precision health and Alzheimer’s disease research by leveraging trusted partnerships, responsive engagement, and a registry-enabled referral pathway. Methods/Study Population: Using a four-way partnership (Institute of Clinical and Translational Sciences Precision Health, research lab partners, Balls-Berry Lab, and community organizations), we implemented a community tailored engagements for adults aged ≥65 at risk for Alzheimer’s disease. Activities included Alzheimer’s education sessions, a sleep-health dinner forum, and direct referrals to active studies. Participants were identified via the local research registry and community networks. Trusted messengers led discussions, facilitated warm hand-offs to coordinators, and supported structured follow-up to sustain engagement and retention. Results/Anticipated Results: In 2025, community events reached >170 participants; >95% identified as Black/African American, and >65% were aged ≥65 years. Across events, about a fourth completed research inquiry cards, with on-site warm hand-offs increasing direct enrollment in active studies. Engagements strengthened trust, improved research literacy, and established a replicable, scalable model. Anticipated 2026 outcomes include expansion to additional precision-health domains, enhanced longitudinal tracking of referrals and enrollments, and broader implementation with urban and suburban partners. Discussion/Significance of Impact: Culturally grounded, community engaged strategies coupled with registry-enabled referrals can measurably improve recruitment, retention, and trust in precision health research, addressing persistent disparities in Alzheimer’s disease studies and accelerating equitable translation.

Objectives/Goals: Evaluate the feasibility, acceptability, and effectiveness of a community-based diabetes management program. Assess participant knowledge, confidence, and skills as initial outcomes, and iteratively refine the pilot program across three phases using participant, facilitator, and observer feedback. Methods/Study Population: The pilot program included cohorts of English and Spanish speaking adults diagnosed with or at high risk for type 2 diabetes. The 5-week training addressed diabetes education, self-management skills, health literacy, and SMART goal setting. Participants completed pre-training, weekly post-session, post-training, and 1-month follow-up surveys to assess knowledge, confidence, satisfaction, and application of skills. Training facilitators and observers from our community engagement team completed weekly post-session surveys to understand strengths, weaknesses, and points of improvement. Feedback from participants, facilitators, and observers were used to iteratively refine the training between phases. Results/Anticipated Results: Findings indicated comparative increases in participant knowledge, confidence, and skill application related to diabetes self-management between English and Spanish cohorts. One-month follow-up data suggested knowledge retention, progress toward SMART goals, and health improvements through application of self-management strategies. Improvements in participant knowledge, confidence, skill application, engagement, and satisfaction were demonstrated across refinement phases. Feedback from participants, facilitators, and observers guided iterative refinements to the training, including materials, format, and delivery across refinement phases, thus ensuring the training was tailored to the community, clear, and accessible. Discussion/Significance of Impact: The pilot demonstrates the feasibility, acceptability, and promising initial outcomes of a bilingual, community-based diabetes management program with potential public health significance. Iterative feedback informed refinements and improved implementation, supporting adaptation of this model for broader community health applications.

Objectives/Goals: The objective of this pilot interventional study is to assess feasibility and preliminary efficacy of implementing a supervised, outpatient aerobic, and strength exercise regimen in newly diagnosed children and young adults with ALL. We hypothesize that early implementation of exercise is feasible and may prevent cardiometabolic late effects. Methods/Study Population: We aim to enroll 10–20 children with newly diagnosed ALL between 11 and 21 years old to participate in a 12-month supervised, structured outpatient exercise regimen (STRONGER ALL). This regimen consists of low- to moderate-intensity aerobic and strength exercises (either in person or coached virtually per patient preference) 3 times a week. This study includes 2 physical fitness assessments: 1) baseline and 2) end of study. Assessments include resting energy expenditure, peak oxygen uptake, bone density, upper and lower extremity strength, flexibility, and questionnaires (feasibility and quality of life). Additionally, blood and urine specimens will undergo metabolomic analysis to identify biomarkers predictive of future cardiometabolic outcomes. In the first year, 7/8 eligible patients have enrolled. Results/Anticipated Results: We expect that early implementation of STRONGER ALL in children undergoing chemotherapy will be feasible and preliminarily effective at mitigating risk factors for long-term cardiometabolic outcomes in survivors. Feasibility will be defined by recruitment capability (at least 50% of eligible patients agree to enroll), acceptance/compliance (at least 50% of participants complete the program with participation in at least 50% of sessions), data acquisition (collection and outcomes measures are appropriate), and practicability (program shows promise of being successful with pediatric ALL patients as measured by validated surveys administered to patients and caregivers). We anticipate that ALL patients participating in STRONGER ALL will have improved fitness and quality of life. Discussion/Significance of Impact: We aim to show that exercise during intensive chemotherapy for children with ALL is safe, feasible, and beneficial. Participants train 3x/week for 12 months (in-person or virtual), complete fitness tests, and answer health and quality-of-life surveys to inform future care. This work addresses barriers to implementing exercise in this population.

Objectives/Goals: This poster presents a landscape analysis of UM1 CTSI community engagement (CE) programs. The University of Michigan (U-M) CTSI, CE team compared services and supports across 27 UM1 CTSIs to identify best practices, unique offerings, and potential models to adopt or adapt to strengthen support for community engaged research (CEnR) at U-M. Methods/Study Population: UM1 websites (n=27) were reviewed to assess publicly available information on CE supports, with focus on CTSIs CE cores. Key elements analyzed included missions, advisory structures, service portfolios, funding and training opportunities, and digital accessibility. Attention was given to how CE cores foster bidirectional learning, build trust, lower barriers to collaboration, and sustain networks – all essential for advancing translational science. Findings and recommendations were compiled to inform possible improvements and new strategies for the Michigan Institute for Clinical and Health Research (MICHR), CE program. Results/Anticipated Results: All CTSIs reviewed operated a CE core, with common offerings in funding and translating science to impact. Over 90% featured community engagement studios; less than 20% charged fees for services. Most (70%) used community advisory boards (CABs) to guide the overall CTSI. Additional services include consultations, matchmaking, and capacity-building to create bridges from early-stage research proposal development through results with real-world impact. Several innovative external models were identified along with unique MICHR offerings.#_msocom_1 Discussion/Significance of Impact: This analysis highlights the diversity and commonalities of CE services across UM1 CTSIs, reveals limitations due to online data availability, and identifies opportunities for MICHR to adopt or adapt external best practices to better support community-engaged research and translational science.