Patrick Alfred Buxton was born in Hyde Park Street, Paddington, on 24 March 1892, and died at his home in Gerrards Cross, Bucks, on 13 December 1955. His father was Alfred Fowell Buxton, a busy banker and one time chairman of the London County Council, his mother was Violet Jex-Blake.

Cis Bidentatus, which acts as host to this gregarine, is a small fungus-eating beetle. Almost all the beetles examined proved to be infected, but the parasites were never very numerous in each host. As a rule the infected beetles contained from four to eight of the sporont associations, and sometimes a few of the cephalont stages or cysts. The adult gregarines may be seen by transparency through the wall of the mesenteron: they lie either straight or else bent in the form of a U, but always with their long axis parallel to the sides of the gut. They are restricted to the posterior region of the midgut, and are never distributed along its whole length.

References to dipterous parasites of Diptera are rare in the literature. Bombyliids of the genera Villa and Thyridanthrax have been reared from the puparia of Glossina; Hemipenthes morio L., from the tachinid Parasetigena segregata Rond., and the sarcophagid Sarcophaga affinis Fall.; Argyramoeba varia F. from the tachinid Sturmia inconspicua Mg. The phorid Hypocera incrassata Mg. was found by H. M. Morris in dead and unhealthy larvae of Bibio marci L. Only one larva of Hypocera was obtained from each specimen of Bibio, and the account given by Morris suggests that this species is a true parasite. The evidence is, however, not absolutely conclusive and further study of this interesting species is desirable. The same thing must be said of E. E. Edwards' record of Aphiochaeta brevicostalis Wood, as a parasite of Tipula sp.

Four years on from the 2nd Edition of this useful introductory text this book remains good value at a modest price rise of only £5.00. In twenty chapters Professor Service follows his well-worked and consistent pattern in each chapter by describing the morphology of each group of vectors, followed by life-cycle, medical importance and control. The further reading information provided at the end of each chapter has been updated wherever relevant. In addition, as an aide-mémoire to revising, certain key words now appear in bold. In many groups, new information is provided on the numbers of species now described. In the case of mosquitoes this is now 3300, an increase of 100 and there are now 4 further genera including Ochlerotatus, a previous subgenus of Aedes. Outstanding developments in control include the innovative development of manufactured bed nets that are impregnated with synthetic pyrethroids, which are designed to release the active molecule over periods as long as four years. Mike Service is, however, cautious, and warns that despite our great hopes for this new development, the incidence of resistance to pyrethroids is a realistic potential threat to its success. In similar vein it is noted that mosquitoes in the laboratory have been observed to develop resistance to the bacterial insecticides Bacillus thuringiensis and B. sphaericus. This has not as yet proved to be a problem in the field with mosquitoes, but experience with agricultural pests, such as the diamondback moth, indicates the need for vigilance.

Viruses are frequently referred to as the supreme parasites and yet it is now more than 20 years since any paper on this topic was published in Parasitology. This deficiency probably reflects the great emphasis placed during the last two decades on those aspects of virology christened by Sir Christopher Andrewes ‘dream virology’ (Andrewes, 1973), namely the molecular and genetic properties of viruses, in contrast to the more clinical and biological aspects of ‘steam’ virology. Many modern virologists select a virus as a convenient model system with which to investigate such things as genetic organization or control of transcription, with little regard for the interaction with the host cell that supports its replication. Paradoxically, it is this very emphasis on the detailed molecular mechanisms of virus replication that has now put us in a better position to understand the relationships between these highly specialized parasites and their host systems than for any other type of parasite. Recent advances in cell biology coupled with an understanding of the molecular basis of viral replicative mechanisms mean that new insight is possible into the interactions of a virus with its host. For example, we are just beginning to appreciate why a virus should infect one individual and not another, or why it should multiply only in certain tissues at certain stages of development of a multicellular organism. Indeed, study of such tropisms may frequently tell us as much about the host cell as about the virus.

Endotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS). We studied endotoxin concentrations in the plasma and cerebrospinal fluid (CSF) of Trypanosoma brucei rhodesiense patients using the chromogenic Limulus Amoebocyte lysate assay. The relationship of endotoxin concentration to the presentation of gross signs of inflammation and the inflammatory/counter-inflammatory cytokine profile of the relevant compartments were analysed. We demonstrate that HAT patients exhibit parasitaemia-independent plasma endotoxaemia, and that this is associated with splenomegaly and lymphadenopathy. Endotoxin concentrations normalize rapidly after treatment. There was no evidence of endotoxin release in the CNS. A rapid normalization of endotoxin levels after treatment and lack of association with parasitaemia suggest that gut leakage is the main source of endotoxin in the circulation. Low CSF endotoxin concentrations and a lack of any association with neuroinflammatory markers or neurological sequelae suggest that endotoxin does not play a role in the pathogenesis of the disease in the CNS.

T. genypteri n.g., n.sp., is described from the stomach of the red ling, Genypterus blacodes Bloch & Schn., in coastal waters of Otago, New Zealand. This genus is characterized by having a small sucker anterior to the oral sucker and two muscle pads in the forebody.

I was much interested in the paper on Herpetomonads in mice in the June number of Parasitology (Fantham and Porter, pp. 128–132). In 1904 or 1905 when working at trypanosomiasis at Khartoum I came across a flagellate in the peripheral blood of a gerbil (Gerbillus pygargus) which was clearly not a trypanosome and the nature of which I was unable to identify.

1. A short note is given on Pterygosoma hystrix Lawrence, 1935, amplifying the original description and extending the known range of variation.

2. The hitherto undescribed male, larva, protonymph and deutonymph of Pterygosoma gerrhosauri Law, 1935, are described and figured.

3. The protonymph and deutonymph of Pterygosoma bicolor Law, 1935, are described and figured, together with a record of variation in the female.

The two genera here considered agree with one another and differ from all the other members of the Lernaeopodidae in having the abdominal appendages dorsal to the eggstrings; and all their species so far described are parasitic upon some species of ray.

Vesiculated protoscoleces (VP) were produced by culturing freshly collected protoscoleces from Echinococcus granulosus horse liver hydatids in RPMI 1640 monophasic medium at 37°C for 18 days. Half of the VP were used as such, the other half used after killing them by freeze—thawing. Nine-day-old chicken heart fragments (CHF) were cultured in MEM at 37°C for 72 h. Subsequently, CHF were put together with live and dead VP, respectively, for up to 53 days, on a semisolid medium consisting of agar, Ringer's and MEM. Time-dependent histological observations revealed that dead VP were surrounded by CHF cells. Dead VP tissue was eventually internalized and disintegrated in about 1 week. Live VP penetrated into the CHF tissue and further developed into small hydatid cysts, located within the boundaries of the experimental ‘host’ tissue. The amorphous-looking contact region PAP-stained positively only with anti-E. granulosus serum and not with anti-CHF serum; it was considered identical to the normal laminated layer. The invasion of VP in CHF tissue proved to be different from a tumour or a bacterial invasion: it was concluded that the confrontation of VP and CHF had resulted in an ‘in vitro cohabitation’ rather than in an ‘in vitro infecion’.

Little is known about the genetic and morphological characters of Taenia ovis. The purpose of the present study was to characterize sheep isolates of T. ovis using rostellar hook morphometry as well as mitochondrial genes sequence analysis. Ninety sheep specimens of Cysticercus ovis were collected from 18 slaughterhouses in Iran. The mean ± s.d. for total length of large and small hooks were 174.1 ± 6.4 and 116.7 ± 5.4 µm, respectively. CO1 and 12S rRNA sequence analysis showed 11 and nine haplotypes, respectively. The level of pairwise nucleotide variations between individual haplotypes of CO1 and 12S rRNA genes were 0.3–1.1 and 0.2–1.0%, respectively. Level of nucleotide variation in CO1 and 12S rRNA between T. ovis haplotypes from present study and eight other Taenia species was found to be 11.3–17.8 and 5.3–16.3%, respectively. Phylogenetic analysis clustered all T. ovis isolates into a single clade comprised of the all CO1 and 12S rRNA haplotypes. CO1 nucleotide difference between T. ovis ovis and T. asiatica was 13.6% that is lesser than the corresponding difference between T. ovis ovis and T. ovis krabbei, warranting the designation of two separate species as T. ovis and T. krabbei. Interclass correlation coefficients showed that there was no significant association between rostellar hook length variation and the variability of the mitochondrial genes.

A description is given of a new species of paruterinid Cestode, belonging to the subfamily Paruterinae Fuhrmann, 1907, of the family Dilepididae Fuhrmann, 1907, to which the name Lallum magniparuterina gen. et sp.nov. is given. It is parasitic in the intestine of the common teal, Nettion crecca Linn.

Some soldiers and workers of Cornitermes orthocephalus, Silv., were taken at Campos, State of Rio de Janeiro, Brazil, in July 1923 by Mr F. Balfour Browne, the leader of a party of Cambridge entomologists which visited South America at that time. One of the worker termites was subsequently found to contain a parasitic worm in its abdomen.

The field of disease ecology – the study of the spread and impact of parasites and pathogens within their host populations and communities – has a long history of using mathematical models. Dating back over 100 years, researchers have used mathematics to describe the spread of disease-causing agents, understand the relationship between host density and transmission and plan control strategies. The use of mathematical modelling in disease ecology exploded in the late 1970s and early 1980s through the work of Anderson and May (Anderson and May, 1978, 1981, 1992; May and Anderson, 1978), who developed the fundamental frameworks for studying microparasite (e.g. viruses, bacteria and protozoa) and macroparasite (e.g. helminth) dynamics, emphasizing the importance of understanding features such as the parasite's basic reproduction number (R 0) and critical community size that form the basis of disease ecology research to this day. Since the initial models of disease population dynamics, which primarily focused on human diseases, theoretical disease research has expanded hugely to encompass livestock and wildlife disease systems, and also to explore evolutionary questions such as the evolution of parasite virulence or drug resistance. More recently there have been efforts to broaden the field still further, to move beyond the standard ‘one-host-one-parasite’ paradigm of the original models, to incorporate many aspects of complexity of natural systems, including multiple potential host species and interactions among multiple parasite species.

Among other cestodes collected by me some years ago were specimens of the prismatic malformation of a tape-worm which I have recently examined. This abnormality in the taenioid group of cestodes has been frequently reported in Europe, especially in Taenia saginata, since Andry's case was first described in 1700. This malformation is known as Taenia ‘tridre,’ ‘triquestre,’ or ‘prismatique’ in French; as ‘dreikantige’ in German, and as ‘tri-radiate’ or ‘prismatic’ in English. But as far as my knowledge goes, we do not find a full description of any such abnormality in Taenia crassicollis, though a brief description of it was given by Bremser in 1819 and 1824. It is now recorded for the first time from Japan.