This study aimed to assess whether intra-operative autologous platelet-rich fibrin glue accelerates nasal mucosal healing after septoplasty.

Prospective, randomised controlled trial of 100 adults undergoing septoplasty, randomised to platelet-rich fibrin glue (n = 50) or standard surgery (n = 50). Primary outcome: endoscopic healing via modified Lund–Kennedy score. Secondary outcomes: Visual Analog Scale pain, crusting, Nasal Obstruction Symptom Evaluation scores and complications.

Platelet-rich fibrin glue significantly accelerated epithelialisation at one week (2.72 vs. 3.46, p = 0.028) and two weeks (1.49 vs. 2.17, p = 0.006). Pain, crusting and Nasal Obstruction Symptom Evaluation scores improved significantly in the platelet-rich fibrin glue group during early follow-up (p < 0.05). No significant differences were observed between groups at four or 12 weeks. Complication rates were low and comparable.

Intra-operative platelet-rich fibrin glue accelerates early mucosal healing and reduces post-operative morbidity during first two weeks after septoplasty without increasing complications. These benefits are confined to early recovery, with equivalent long-term outcomes.

This study aimed to evaluate the efficacy of diced cartilage and platelet-rich fibrin–wrapped diced cartilage in nasal septal perforation repair.

Thirty-six rabbits were allocated to three groups. The Control group underwent repair with flaps; the Diced Cartilage group received cartilage grafts with flaps; and the Diced Cartilage plus Platelet-Rich Fibrin group received platelet-rich fibrin–coated diced cartilage with flaps.

Persistent perforations occurred in all controls. Closure rates were 66.7 per cent in the Diced Cartilage group and 81.8 per cent in the Diced Cartilage plus Platelet-Rich Fibrin group, both significantly higher than controls (p < 0.001), with no significant difference between graft groups. Fibrosis level and re-epithelialisation scores were significantly increased in both graft groups versus controls (p < 0.001).

Inter-positional graft use is crucial for successful nasal septal perforation repair; diced cartilage is an effective alternative when block cartilage is unavailable, and platelet-rich fibrin combination may further enhance outcomes.

This study aimed to evaluate the clinical efficacy and potential immunomodulatory effects of autologous platelet concentrates in promoting tissue regeneration and enhancing post-operative recovery in otorhinolaryngology.

A systematic search of PubMed, Scopus and the Cochrane Library was conducted through November 2025, focusing on randomised controlled trials and prospective studies using autologous platelet concentrates in otological, rhinological and laryngological surgery.

Twelve studies met the inclusion criteria. Autologous platelet concentrates improved tissue healing, most notably by increasing graft uptake rates in myringoplasty. Recent trials (2024–2025) also reported reduced post-operative pain and mucosal oedema following tonsillectomy and tympanoplasty.

Autologous platelet concentrates appear to be effective adjuncts for enhancing regeneration and reducing post-operative morbidity in ear, nose, and throat procedures. These benefits likely involve downregulation of pro-inflammatory cytokines (e.g., interleukin-6) and modulation of matrix metalloproteinases (e.g., matrix metalloproteinase-9). Standardised biomarker-based studies are needed to confirm these mechanisms.

Cubism graft technique offers controlled thinning of the cartilage and prevents over-curling. This article compares tragal perichondrium with the new cubism graft in tympanoplasty in small- to medium-size tympanic membrane perforations.

In our study, we included 40 patients, where tragal perichondrium was used as a graft in 20 patients, while cubism graft with tragal cartilage was used in the other 20 patients.

Only two patients had a failure in graft uptake in the tragal perichondrium group, while three patients had a failure in graft uptake in the group where cubism graft with tragal cartilage was used. Significant closure of the air-bone gap (≥ 9 dB) was observed in post-operative audiogram at three-month follow-up in both groups.

This study concludes that the new cubism graft is comparable to tragal perichondrium graft in terms of graft uptake and closure of the air-bone gap.

To evaluate the impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes.

Patients who underwent tympanoplasty type 1 surgery were randomised into temporal fascia graft alone (n = 55) and temporal fascia graft plus platelet-rich fibrin therapy (n = 36) groups. Graft survival and hearing outcomes were recorded.

Graft survival rates were significantly higher in the temporal fascia graft plus platelet-rich fibrin therapy group than in the temporal fascia graft alone group at one (100.0 vs 85.5 per cent, p = 0.020), three (97.2 vs 80.0 per cent, p = 0.024) and six months post-operatively (94.4 vs 74.5 per cent, p = 0.031). The difference in hearing gain between groups was not significant.

Our findings revealed that the use of a platelet-rich fibrin plus temporal fascia graft for type 1 tympanoplasty was associated with more favourable post-operative outcomes than the use of temporal fascia alone, both in terms of tympanic membrane healing and graft survival; hearing restoration outcomes were similar.