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The biologically active form of vitamin D (1,25(OH)2D) is involved in the regulation of calcium and phosphorus, influencing bone formation and probably fetal growth and development. However, 1,25(OH)2D has a very short half-life, and 25(OH)D is the main circulating metabolite, making it the ideal clinical indicator. Given the lack of prospective epidemiological cohort studies exploring the relationship between maternal 25(OH)D and fetal growth and adiposity, the aim of this study was to evaluate the association of maternal 25(OH)D concentrations with fetal biometry and adiposity at three periods of pregnancy. This prospective study included 330 women participating in the Araraquara Cohort Study, Brazil, who were evaluated at gestational ages ≤19, 20–28 and ≥30 weeks. 25(OH)D concentrations were measured by chemiluminescence. The following fetal outcomes were assessed by ultrasound: biometric (estimated fetal weight, femur length, abdominal circumference, head circumference and biparietal diameter) and adiposity parameters (subcutaneous tissue of the abdomen and subcutaneous areas of the thigh and arm). Generalised estimating equation models adjusted for maternal sociodemographic, lifestyle, nutritional, clinical and biochemical factors were used. In the unadjusted analysis, 25(OH)D ≥ 75 nmol/l was associated with higher fetal biometry and adiposity measures. After adjusting for potential confounders, for each increase of 10 nmol/l in 25(OH)D, there was a 0·0046 cm increase in fetal head circumference (β = 0·0046 [95 % CI 0·0003, 0·0089]; p = 0·04). Maternal 25(OH)D was associated with greater head circumference, suggesting a possible role of 25(OH)D in fetal cranial development and reinforcing the importance of implementing prenatal monitoring of 25(OH)D concentrations.
We provide an updated overview of standard and advanced neuroimaging techniques used in the evaluation of brain abnormalities in fetuses, newborns, and young infants, emphasizing how imaging can identify patterns and estimate the timing of brain injury, helping to distinguish between static malformations, acquired injuries, and progressive or metabolic conditions. Common developmental abnormalities (e.g., neural tube defects, disorders of brain folding and growth, and structural anomalies like cephaloceles and Dandy–Walker malformation) are discussed. The chapter also covers trauma, stroke, brain hemorrhage, infections before or around birth (cytomegalovirus, toxoplasmosis, and rubella), and bacterial infections like meningitis or abscesses. Inherited and acquired metabolic disorders affecting gray and white matter are also illustrated. Techniques such as functional imaging, brain perfusion studies, and chemical analysis using spectroscopy are included. Practical considerations regarding radiation safety, sedation, and use of infant-friendly equipment are addressed, alongside recent technological advances like artificial intelligence–based image enhancement and low-dose CT.
Effective wildlife monitoring generates valuable information, but it needs to be cost-effective because conservation funding is scarce. Passive acoustic monitoring facilitates monitoring and occupancy estimates of cryptic species, but is rarely used for terrestrial mammals vocalizing in ultrasound (> 20 kHz). Here, we compared the recording quality of two autonomous recording units: Open Acoustic’s AudioMoth and the Wildlife Acoustics Song Meter Mini Bat 2. In June 2024, we conducted an experiment in north-east Thailand, playing modulated ultrasonic sounds in three forest environments. We conducted 108 trials at varying distances during the day and night. We measured the average decibels for each trial and found that the AudioMoth consistently provided equivalent dB readings of ultrasound on spectrograms and detected ultrasonic tones from further away than the Song Meter Mini Bat 2. These data indicate that the AudioMoth could be a cost-effective option for detecting modulated ultrasound at distances of up to 32 m. Cost often limits deployment of monitors, and the ability to maximize efforts while minimizing cost is essential for improved species monitoring.
Deep vein thrombosis (DVT) commonly presents as unilateral leg swelling and pain. Risk factors for DVT include malignancy, recent surgery, history of DVT/PE, genetic predisposition to a hypercoagulable state, hospitalization, OCP/hormone replacement, pregnancy, and prolonged immobilization. D-dimer can help rule out DVT in patients with a low suspicion for DVT. Ultrasound, specifically compression ultrasonography, is a reliable way to diagnose DVT. Failure of a vein to completely compress with compression ultrasonography is diagnostic of a thrombus. Outpatient treatment with direct oral anticoagulants such as rivaroxaban and apixaban is typical. Some patients may be treated with low-molecular-weight heparin (LMWH), or LMWH bridge to warfarin. Patients with a DVT should also be evaluated for signs or symptoms of a pulmonary embolism (PE).
A case to prepare the reader for the emergency medicine oral boards examination. it discusses appropriate management of tension pneumothorax, including case presentation, key actions, and clinical reasoning.
Care of the patient with traumatic injuries begins with the ABCs. Airway must be secured before proceeding with other evaluation and treatment. Penetrating chest trauma can cause a pericardial effusion and cardiac tamponade. Recognition of pericardial effusion and diagnosis of cardiac tamponade is an imperative skill for the emergency physician. Identifying Beck’s triad of hypotension, distended neck veins, and muffled heart sounds can assist in the diagnosis of cardiac tamponade. Bedside ultrasound and the eFAST exam can confirm the diagnosis. On a cardiac view of the eFAST, pericardial effusion appears as an anechoic or hypoechoic stripe between the visceral and parietal layers of the pericardium. Tamponade is the collapse of the right ventricle during diastole, preventing filling of the heart. Traumatic pericardial effusions are typically caused by bleeding into the pericardium. Initial treatment of cardiac tamponade begins with fluid resuscitation, thus increasing preload capacity. Needle pericardiocentesis of traumatic pericardial effusions are temporizing measures, as blood quickly reaccumulates into the pericardium. Cardiac arrest may occur due to cardiac tamponade. ED thoracotomy should be performed to directly tamponade bleeding from the ventricle, and surgery should be consulted to take the patient to the OR for definitive repair.
This chapter reviews the normal anatomy, fractures and challenges of the upper extremity frequently encountered in child abuse imaging. Specifically, fracture types of the humerus, the elbow and the forearm are examined with attention to imaging techniques and protocols, particularly radiography and ultrasound.
This chapter provides a summary of longstanding and updated research for the accurate diagnosis of fractures of the clavicle, sternum and scapula in the setting of suspected physical abuse of infants and young children. Findings key to diagnosing fractures by radiographic skeletal survey, computed tomography, ultrasound and magnetic resonance imaging are demonstrated with numerous representative examples. A section for each of these anatomical regions includes a detailed review of anatomy and injury mechanisms in addition to characteristic imaging features. Considerations for differential diagnosis and pitfalls in interpretation are presented specific to each anatomic area. Attention to imaging technique and careful evaluation of findings are emphasized to promote proper diagnosis.
This chapter reviews the imaging approach in suspected child physical abuse, including differing presentations of child physical abuse as well as recommendations for screening children at risk. Imaging strategy of the skeleton, including radiography, chest CT, ultrasound, whole-body MR and radionuclide bone imaging is reviewed.
This chapter discusses skeletal injuries associated with obstetric trauma during the birth process. The prevalence of obstetric injuries has decreased with modern obstetric techniques, but major injuries still occur, providing valuable insights into the mechanisms involved in similar lesions seen in abuse cases.
This chapter highlights specific types of injuries, such as clavicular fractures, long bone injuries (including subperiosteal new bone formation and fractures) and rib fractures. Clavicular fractures are the most common site of obstetric fracture, often occurring with relatively uneventful vaginal births of large babies. Long bone injuries include subperiosteal new bone formation and fractures, which may present similarly to abuse-related injuries. Radiographs and sonography play a crucial role in characterizing the extent and nature of these injuries.
This chapter emphasizes the importance of understanding and differentiating obstetric injuries from abuse-related injuries, as well as providing valuable information about the biomechanics, natural history and imaging characteristics of inflicted skeletal injuries during birth.
Joshua Lowe, San Antonio Military Medical Center,Rachel Bridwell, Uniformed Services University of Health Sciences,John Patrick, San Antonio Military Medical Center,Alec Pawlukiewicz, Carl R. Darnall Army Medical Center,Gillian Schmitz, Uniformed Services University of Health Sciences,Michael Yoo, University of Texas Health San Antonio
This clinical vignette explores the complex decision-making involved in terminating resuscitation after prolonged, unsuccessful advanced cardiac life support (ACLS) for a 72-year-old female in unwitnessed cardiac arrest. Despite high-quality CPR, PEA persisted without return of spontaneous circulation (ROSC), and serial assessments showed a non-perfusing rhythm, absent cardiac motion on ultrasound, and persistently low end-tidal CO₂. Reversible causes were systematically ruled out using the Hs and Ts framework. After 20 minutes of resuscitation and no signs of ROSC, the code team, led by the resident, called time of death. This case emphasizes the use of ETCO₂, point-of-care ultrasound, and AHA termination of resuscitation (TOR) criteria, while modeling collaborative leadership and thoughtful clinical judgment in high-stakes decision-making.
Ultrasound is the most commonly used medical imaging method in pregnancy. In early pregnancy a scan is performed to confirm the presence of a normally sited pregnancy, establish viability, determine number of embryos, determine gestational age and hopefully to reassure about the absence of complications. Ultrasound used with standard presets for clinical reasons in early pregnancy is safe and the benefits outweigh any theoretical risks.
This case involves likely casualties that may present to a facility following a mass gathering stampede incident. Patients within this context may present with blunt polytrauma and subtle signs of impending decompensation that portend catastrophic outcomes if not caught early during the standardized trauma evaluation. The nature of a mass gathering, mass casualty event is such that external factors and players may provide unanticipated barriers to care at critical moments. Rapid identification and mitigation of these confounders and confederates are critical, in order to prevent degradation of high-efficacy trauma care for potentially complex and critical ill patients.
Depression is a common comorbidity in neuropsychiatric disorders, affecting a significant proportion of patients with neurodegenerative diseases. Traditional antidepressants show limited efficacy, particularly in cases involving comorbid depressive symptoms, highlighting the need for alternative treatments.
Methods
Here we provide the first data on possible benefits of add-on therapy with transcranial pulse stimulation (TPS). Based on the largest patient sample in the emerging field of focused ultrasound (FUS) neuromodulation to date, a retrospective analysis was conducted on 88 patients with various neuropsychiatric diagnoses to evaluate the impact of TPS on depressive symptoms, measured by the Beck Depression Inventory (BDI-II).
Results
The study revealed significant improvements in BDI-II scores posttreatment (N = 88), with the most substantial effects observed in more severely impacted patients: individuals with minimal to severe depression (BDI-II ≥9; N = 32) experienced an average reduction of 5.22 points (29.46%), while those with mild to severe depression (BDI-II ≥14; N = 15) showed an even greater mean improvement of 10.40 points (40.51%). These results surpassed established thresholds for clinical relevance and substantially exceeded placebo effect sizes observed in relevant brain stimulation studies. Moreover, depression score improvement was independent of diagnostic group (dementia, movement disorders, or other), improvement of the primary diagnosis, antidepressant medication, and baseline cognitive status, highlighting the potential of TPS as an effective therapeutic add-on intervention for patients receiving state-of-the-art treatments.
Conclusions
The study’s findings indicate that TPS enhances depression outcomes in neuropsychiatric patients, particularly in those with more severe depressive symptoms.
We compare the complexity of idiosyncratic sound patterns involving American English /ɹ/ with the relative simplicity of clear/dark /l/-allophony patterns found in English and other languages. For /ɹ/, we report an ultrasound-based articulatory study of twenty-seven speakers of American English. Two speakers use only retroflex /ɹ/, sixteen use only bunched /ɹ/, and nine use both /ɹ/ types, with idiosyncratic allophonic distributions. These allophony patterns are covert, because the difference between bunched and retroflex /ɹ/ is not readily perceived by listeners. We compare this typology of /ɹ/-allophony patterns to clear/dark /l/-allophony patterns in seventeen languages. On the basis of the observed patterns, we show that individual-level /ɹ/ allophony and language-level /ɹ/ allophony exhibit similar phonetic grounding, but that /ɹ/-allophony patterns are considerably more complex. The low complexity of language-level /l/-allophony patterns, which are more readily perceived by listeners, is argued to be the result of individual-level contact in the development of sound patterns. More generally, we argue that familiar phonological patterns (which are relatively simple and homogeneous within communities) may arise from individual-level articulatory patterns, which may be complex and speaker-specific, by a process of koineization. We conclude that two classic properties of phonological rules, phonetic naturalness and simplicity, arise from different sources.
Much progress has been made in the last 200 years with regard to understanding the origins and mechanisms of sound change. It is hypothesized that many sound changes originate in biomechanical constraints on speech production or in the misperception of sounds. These production and perception pressures explain a wide range of sound changes across the world's languages, yet we also know that sound change is not inevitable. For example, similar phonological structures have undergone change in many languages yet remained stable in others. In this study, we examine how typologically unusual contrasts are maintained in the face of intense pressures, in order to uncover the potential biomechanical, perceptual, and sociolinguistic factors that facilitate the maintenance of typologically unusual contrasts. We focus on secondary articulation contrasts in Scottish Gaelic rhotics, triangulating auditory, acoustic, and articulatory data in order to better understand the maintenance of contrast in the face of multidimensional typological challenges. Here, individual-level articulatory strategies are combined with contextual prosodic information in order to maintain acoustic and auditory distinctiveness across three rhotic phonemes. We highlight the need to more comprehensively consider typologically unusual and minority languages in order to test the limits of generalizations about crosslinguistic phonetic typology.
A field-based ultrasound and acoustic study of Iwaidja, an endangered Australian Aboriginal language, investigates the phonetic identity of nonnasal velar consonants in intervocalic position, where past work has proposed a [+continuant] vs. [-continuant] phonemic contrast. We analyze the putative contrast within a continuous phonetic space, defined by both acoustic and articulatory parameters, and find gradient variation: from more consonantal realizations, such as [ɰ], to more vocalic realizations, such as [a]. The distribution of realizations across lexical items and speakers does not support the proposed phonemic contrast. This case illustrates how lenition that is both phonetically gradient and variable across speakers and words can give the illusion of a contextually restricted phonemic contrast.
Edited by
Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath,Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester,Alex Goodwin, Royal United Hospitals NHS Foundation Trust, Bath,Samuel Nava, Severn Deanery, Bristol
The final chapter in the book covers some specific electrical devices used in surgery, anaesthesia and critical care. Firstly, we discuss defibrillators where exam candidates are expected to have a good working knowledge and be able to both draw and explain the relevant electrical circuit. Secondly we discuss surgical equipment in LASER and diathermy, both of which carry detail in their different types, risks of harm and safety requirements. Finally the chapter discusses medical ultrasound, how it is generated and used in clinical practice.
William Fawcett, Royal Surrey County Hospital, Guildford and University of Surrey,Olivia Dow, Guy's and St Thomas' NHS Foundation Trust, London,Judith Dinsmore, St George's Hospital, London
Vascular access is a fundamental skill in anaesthesia and intensive care, not only for drug administration but also for delivery of fluids and blood products, and for sampling for blood tests. Peripheral venous access is used for all patients undergoing surgery, but for major surgery and/or very unwell patients, central venous access and arterial access may also be required.
Flow rates through cannulae are key in determining the size of cannula chosen, and are proportional to the fourth power of their internal radius. All vascular access must be inserted aseptically, and removed if signs of infection develop. Serious complications, particularly after central venous access are well described including pneumothorax, haemothorax and cardiac tamponade. The use of ultrasound for facilitating access is mandated for central access, but is also increasing for both more difficult arterial and peripheral venous access.
Transvaginal ultrasound scan is the mainstay of diagnosis of miscarriage. Evidence based criteria should be fulfilled in all cases, with interval scans as needed to avoid inadvertent interventions when the pregnancy may be viable. Incomplete, inevitable and complete miscarriages have specific ultrasound findings. Several ultrasound factors, including slow embryonic heart rate, small embryo or gestation sac size and an enlarged yolk sac, alone or in combination, help predict impending pregnancy loss. Uterine factors such as fibroids, adenomyosis and adhesions after previous caesarean birth may make ultrasound assessment for early pregnancy more challenging.