By detailing a long-disputed measurement application from astrobiology, I analyze the relations between theoretical assumptions, research questions, measurement procedures, manufactured effects, and genuine phenomena in measurement robustness (MR). First, I present a problem about measurement standards in MR by examining divergent results, partially reliable procedures, and contradictory measurement standards in the “arsenic life” case study. Second, I show that the resolution to this problem requires examining the central role of divergence upstream in measurement methodology and extending MR beyond results and procedures. I illustrate how discipline-specific assumptions moderate measurement standards and research questions, as well as how those assumptions influence the manipulation of measurement conditions, which can result in artifact production, genuine effect destruction, or the creation of instructive effects.