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Recent studies indicate that anxiety is one of the most prevalent mental health challenges faced by children and adolescents diagnosed with autism spectrum disorder (ASD).
Methods:
For young individuals with concurrent Intellectual disability disorder, these rates are projected to be significantly elevated.
Results:
Despite the estimated high prevalence of anxiety among young individuals with co-occurring ASD and intellectual developmental disorder (IDD), significant uncertainty remains in the field about the most effective methods for identifying, diagnosing, and treating anxiety in this distinct group.
Conclusions:
The main objective of this narrative review is to examine the current literature on effective strategies and adjustments for evaluating and treating anxiety in children and adolescents who have co-occurring ASD and IDD, aiming to support professionals engaged with this significantly neglected group.
Eco-anxiety, characterised by persistent or intense anxiety about environmental crises, is a growing global mental health concern. Yet, the design, effectiveness and implementation of interventions specifically targeting eco-anxiety lack a comprehensive synthesis. This systematic review examined peer-reviewed studies published between 2010 and 2025 that reported on interventions designed to prevent, manage or reduce eco-anxiety or closely related climate-related psychological distress, defined as sustained emotional, cognitive or functional impairment linked to environmental change. Searches were conducted across CINAHL, PsycINFO, MEDLINE, Scopus, ProQuest Environmental Science Collection and the Cochrane Central Register of Controlled Trials. Twenty-two studies met the inclusion criteria from an initial 1,259 records. Most were published between 2017 and 2025, primarily in high-income Western countries, and encompassed a broad range of interventions including educational programmes, messaging strategies, cognitive-behavioural and mindfulness-based therapies, group resilience training, nature-based approaches and community participation initiatives. Cognitive-behavioural and mindfulness-based interventions showed the most consistent positive findings within the current evidence base, including repeated reports of reductions in eco-anxiety or climate-related distress and, in some studies, maintenance of improvements at short-term follow-up. Educational and community-focused interventions were more likely to be associated with emotional engagement, agency and peer support rather than solely increasing knowledge, with some approaches increasing concern or emotional engagement without reducing distress. However, substantial heterogeneity in outcome measures, short intervention durations and limited follow-up periods constrained comparison across studies and assessment of longer-term impact. Implementation challenges included issues of scalability, cultural relevance and the predominance of researcher-led, time-bound interventions. Within the limited literature to date, interventions integrating emotional resilience training with group or community engagement appeared to show promising findings. Further research using standardised outcome measures, longer follow-up periods and more culturally diverse and participatory designs is required to strengthen the evidence base and inform scalable, context-sensitive responses to eco-anxiety.
Anhedonia, the diminished interest and/or capacity for pleasure, is increasingly recognised as a transdiagnostic symptom that spans mood, anxiety, neurodevelopmental and psychotic disorders. Rather than being specific to any single disorder, anhedonia reflects core dysfunction in reward processing and affect regulation, with broad implications for social and functional outcomes.
Worldwide, the increasing trend of young people experiencing mental health challenges constitutes a major public health concern. There is a need for preventive and mental health-promoting initiatives targeting youths. This study examines the effectiveness of headspace Denmark – a nationwide counseling service for 12- to 25-year-olds – at 6-month follow-up.
Methods
The study was a quasi-experimental trial. 12- to 25-year-olds who had participated in counseling sessions in headspace were matched with a comparable control group, using propensity score matching. Survey data, collected at baseline and at 6-month follow-up, were linked to national register data. Outcome measures were well-being, loneliness, self-efficacy, life satisfaction, and health-related quality of life. Linear regression was used to test differences between the two groups. Subgroup analyses were conducted. Post-hoc Population Attributable Fractions (PAFs) were estimated to describe the effect sizes at the population level.
Results
The inclusion period was 14.5 months from September 2022. Follow-up data were collected until mid-August 2024. The number of participants in the intervention group was 1,362. In the control group was 3,192. A statistically significant difference between the groups was observed for well-being at 6-month follow-up (Cohen’s D = 0.11; p = 0.018). The estimated PAF was 4%, assuming a prevalence of low well-being in the target group of 70% and the intervention reaching 80% of the target group.
Conclusions
headspace had an effect on participants’ well-being. Based on the estimated PAF, headspace can play a crucial role in early health promotion and disease prevention among young people in Denmark.
Although much has been written of the social and structural determinants of mental health and the mental health professional’s role in intervening to redress them, little has been explicitly written on how these factors interact with the prescribing process. Using the nine subdomains outlined by Compton and Shim, this chapter explores how to better understand the extraclinical factors impacting prescribing, integrate them into a broadened prescribing process, and formulate interventions to address them. Concrete recommendations are made for the individual, system, and structural levels.
Awareness of the structural context of prescribing is essential for clinicians to provide appropriate care to our patients. However, there is an opportunity to move beyond this awareness and be active participants in changing the structural factors that impact health and illness. This chapter highlights examples of healthcare workers and systems addressing such structural determinants and moving toward justice. We offer ideas of how clinicians can take action, from the individual physician–patient relationship to policy-level change.
This chapter offers an overview of the book, outlining the emerging profile of strengths and vulnerabilities among international adoptees as a distinct subpopulation across ages, life stages, and cultural contexts. It also underscores the invaluable contributions this group has made – and continues to make – to research and theory on human development. In doing so, the chapter explores how adoption intersects with broader developmental processes, providing insights into resilience, identity formation, and adaptation in diverse environments. Finally, it identifies critical gaps in current knowledge and proposes directions for future research to deepen our understanding of this unique population.
Behaviour-change interventions unfold in social systems where people learn from others. We develop a stylised agent-based model to examine how four canonical social learning rules – conformist transmission, informational prestige-biased copying, payoff-biased copying and random copying – shape the impact of a simple seeding intervention. Two arms evolve under identical conditions and learning rules, differing only in initial adoption: both start with exactly 5% baseline adopters and the treatment arm additionally seeds 20% of the remaining non-adopters, yielding an exact 25% vs 5% contrast at $t = 0$. Across homogeneous populations, 70/30 mixed ecologies and sweeps over the share of payoff-biased learners, we track adoption trajectories and treatment–control lift; we also vary payoff parameters, prestige informativeness and conformist thresholds in robustness analyses. We find that the same seeding intervention can stall, drift or cascade depending on the learning ecology. In the baseline specification, conformist dynamics exhibit threshold effects that erase treatment gains, prestige-biased and random copying can preserve positive final lift when diffusion remains incomplete and payoff-biased copying mainly changes the diffusion regime rather than preserving large end-point gaps. Robustness checks show that negative payoff premia suppress diffusion, weak or noisy payoff signals can generate treatment advantages, prestige effects depend on how informative prestige is and conformist treatment effects are concentrated in narrow threshold-boundary regions. These results motivate policy heuristics that evaluate interventions relative to local diffusion potential, make successful outcomes visible when payoff cues matter and tailor seeding to the prevailing mix of learning rules.
Adolescent involvement in mental health prevention research remains limited in low-resource settings. This study examined the feasibility, acceptability, processes and perceived impacts of adolescent advisory groups (AAGs) within the ALIVE research in Colombia, Nepal and South Africa. Using a convergent mixed-methods design, we analysed data collected between October 2022 and August 2025 using surveys with adolescents (t1: n = 33; t2: n = 26), focus group discussions (n = 6 with adolescents; n = 2 with caregivers), interviews (n = 8 with adolescents; n = 5 with facilitators), process documents (n = 58) and post-session feedback (n = 7). Participation was highly valued by most adolescents, who were motivated by altruism, peer connection, skill development and project incentives. Most adolescents strongly agreed they could express their views freely (t1: 79%; t2: 81%) and felt listened to (t1:76%; t2: 81%, respectively). Participants reported experiences of trust, confidence and collective agency; challenges included stigma, unequal participation and logistical barriers. Facilitators’ relational and adaptive support appeared central to sustaining engagement. Adolescent members contributed in important ways to the ALIVE research. Adolescent involvement in prevention research in low-resource settings is feasible and can be experienced by participants as valuable.
Racism is a fundamental threat to human rights and to child and youth health and wellbeing. Addressing racism is a human rights priority and essential to ensuring all children and youth are able to realize optimal health, development, and wellbeing. This chapter first provides a brief overview of the multiple ways racism operates to impact child and youth health, development and wellbeing in school settings, drawing on qualitative and quantitative data on the prevalence and impacts of racism in schools, and children and young people’s views regarding potential remedies. It then discusses principles of anti-racism interventions in school settings and evidence-based exemplar programs. We primarily draw on our experience and learnings within an Australian context, recognizing that while racism and its expressions share many similarities across settler-colonial settings, there are also considerable historical and contemporary social and political differences.
Ageism, defined as stereotypes, prejudices, and discrimination based on age, is a pervasive phenomenon across individuals, settings, historical periods, and cultures. To address the universality of ageism, we explore three main questions: (a) Does ageism happen throughout the course of a person's life? (b) Does ageism permeate all spheres of life? (c) Does ageism exist all around the world? We conclude that although ageism is universal, there are substantial variations in its definition, manifestations, and impact over time and in different sociocultural contexts. The variability identified suggests that we cannot use a one-size-fits-all approach to conceptualize or target ageism, but instead we should adopt a personalized approach, which considers the sociocultural context, the personal attributes of the targets and agents of ageism, and the normative framework concerning ageism at the global and local levels. This title is also available as Open Access on Cambridge Core.
This chapter discusses the various ways in which we've struggled to fight against or live with the weather. It frames this discussion as an exploration of dispositional attitudes and suggests that the moral valence of weather is in part a consequence of the technologies and policies we have developed to mitigate risk. Roofs, gutters, aqueducts, pumps, shades, fabrics, paints, umbrellas, parasols, and sunscreen have all done considerable work to dampen or amplify the impacts of weather on our lives. It also reflects on the three historically significant agricultural revolutions and ties them into the emergence of technologies and policies that we have used to intervene with weather. These technical innovations have themselves also shaped whole economies, transformed cities, and affected the physical landscape in which we live. It stresses in particular how contemporary theorists have sought to capture weather as one of many “ecosystem services,” an actuarial abstraction that further reframes weather, not as an unending cascade of unpredictable hazards, but instead as a gift of free services from nature. In the end, it suggests that this transforms our relationship to weather almost entirely into impact terms. The primary purpose of this chapter is to make a practical point: that weather presents a kind of ongoing, forever-looming natural hazard, but as we've been able to soften the blow of weather through practical and technical means, we have changed how we live and how we view weather.
Schools play a crucial role in supporting adolescent mental health, especially in low- and middle-income countries (LMICs), where young people face structural and societal challenges. This study explores the feasibility and acceptability of the Health Action in Schools for a Thriving Adolescent Generation (HASHTAG), a multilevel intervention for at-risk adolescents aged 13–14 in South Africa. HASHTAG includes two components: thriving environment in schools (TES), a whole-school approach, and thriving together (TT), a classroom-based programme. Using a mixed-methods design, we assessed feasibility in two Khayelitsha schools through implementation measures (attendance, fidelity and acceptability), focus groups (n = 46), and pre-post surveys (n = 231). Despite COVID-19 disruptions, the intervention was implemented with high fidelity and met all progression criteria. Students and staff found HASHTAG relevant and engaging, particularly appreciating the TT sessions delivered by external facilitators. The TES teacher module also created space for reflection and self-care. Some teachers suggested improved sensitisation could strengthen the programme’s impact. Although no significant changes were observed in quantitative outcomes, no harms were reported. These findings support the feasibility and acceptability of HASHTAG and highlight the need for a full-scale trial to evaluate its potential impact on adolescent mental health in LMIC settings.
Professional burnout syndrome represents a significant occupational hazard within European primary care physicians, impacting their well-being, quality of care, and the sustainability of healthcare systems. This joint European Psychiatric Association (EPA) and the World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians- Europe Region (WONCA Europe) viewpoint focuses specifically on primary care physicians, contrasts their risk profile with other specialties, and outlines actionable, system-level recommendations for policymakers, provider organizations, and professional associations. Evidence indicates a wide range in professional burnout syndrome prevalence, influenced by assessment methodologies and specific national contexts. The syndrome manifests through emotional exhaustion, depersonalization, and reduced personal accomplishment, often accompanied by secondary psychological and physical symptoms. A multitude of interacting risk factors at the individual, interpersonal, and organizational levels contribute to its development. Effective mitigation strategies necessitate a multi-pronged approach encompassing individual coping mechanisms and systemic organizational changes aimed at alleviating workload, enhancing autonomy, and fostering supportive work environments.
Survivors of critical illness are at increased risk for the development of functional impairments, including difficulties performing activities of daily living and instrumental activities of daily living. This chapter explores the role of occupational therapy (OT) in the rehabilitation of patients impacted by post intensive care syndrome (PICS). Specific evaluation tools used by occupational therapists that can be assess PICS patients to identify their impairments in the key areas of physical, cognitive, and mental health are described. Thereafter, interventions used by occupational therapists to remediate identified impairments and maximize independence are described, derived from a combination of evidence-informed practice in similar patient populations and current empirical evidence for PICS rehabilitation.
When do politicians debate each other in parliament, and when do they prefer to avoid discourse? While existing research has shown MPs to unilaterally leverage the dialogical nature of legislative debates to their advantage, the circumstances facilitating actual discursive interaction have so far received less attention. We introduce a new framework to study the emergence of discourse in political debates. Applying this framework, we expect ideological differences and government–opposition dynamics to shape politicians' choices about seeking or avoiding discourse. To test these hypotheses, we draw on an original dataset of all 14,595 attempted and successful interventions (Zwischenfragen) – extraordinary, voluntary discursive exchanges between speakers and MPs in the audience – in the German Bundestag (1990–2020), extracted using an annotation pipeline developed specifically for this study. We find that MPs separated by diverging preferences seek discourse with one another more often than their ideologically aligned counterparts. At the same time, these exact attempts do less frequently result in discursive interactions. When considering government–opposition dynamics in this process, we observe very similar patterns: Attempts to initiate discourse are particularly common among opposition MPs facing government speakers, and we find tentative evidence suggesting that government actors are most likely to avoid these invitations to discursive interaction. Our findings have important implications for our understanding of elite behaviour in public environments.
People with tuberculosis (TB) and TB survivors are at increased risk for mental health (MH) conditions. Better management of conditions like depression can improve adherence to TB treatment, and integrating MH care into TB treatment may reduce the MH treatment gap and improve outcomes. This qualitative study explored design characteristics for integrated MH-TB care in Pune, India. Data collection involved in-depth interviews (n = 25) with TB survivors with lived experience of MH conditions, their family members, and TB and MH providers. Data collection and analysis were guided by the Consolidated Framework for Implementation Research, and journey maps illustrated patient experiences. Participants shared suggestions for integrated care models, advantages and barriers to integration, intervention delivery agents, and local perceptions of MH conditions. Barriers included limited awareness about MH and perspectives about MH treatment, which were limited to consuming medication. Suggestions for integrated interventions included raising awareness about MH conditions and existing MH services among TB providers, regular MH screening and counseling for people with TB, and engaging TB survivors to share their experiences with patients in group settings. These insights highlight the importance of working with people with lived experience and understanding patient journeys to inform intervention implementation and sustainability.
Fidelity – ensuring interventions are implemented as intended – is a key focus in implementation science. Despite its benefits in research and practice, data on the fidelity of implementation are often overlooked, measured inconsistently, or underreported. In 2024, we proposed a preliminary guideline for one component of fidelity – the fidelity of delivery in parenting interventions. This study builds upon that work, refining the guideline for psychosocial and behavioral interventions.
Methods:
Using a modified Delphi technique, we refined the Fidelity of Intervention delivery in Psychosocial and behavioral Programs (FIPP) guideline. The process included survey responses (n = 34), two panel consensus meetings (n = 10), and email feedback (n = 5) resulting in six rounds of iterative revisions to produce the final FIPP.
Results:
The modified Delphi technique resulted in a final FIPP with 35 items across six categories: intervention, facilitator, fidelity measure, and fidelity assessor characteristics; fidelity assessment method; and fidelity results and discussion. The final FIPP was produced based on engagement and data from the survey participants, consensus meeting panelists, and email panelists.
Conclusions:
This study advances reporting on fidelity of delivery in psychosocial and behavioral interventions by refining the FIPP guideline through a rigorous, consensus-driven process. The FIPP provides a comprehensive structure to improve the consistency and transparency of fidelity of delivery assessment. By promoting standardized reporting, the FIPP enhances the quality of implementation science, ultimately supporting more effective interventions and better participant outcomes. Researchers and practitioners are encouraged to adopt the FIPP to strengthen intervention fidelity and drive meaningful progress in the field.
People living with severe mental illness (SMI) experience a shorter life expectancy and poorer physical health than those without SMI. Cardiometabolic illness accounts for a significant proportion of this health inequality. Pharmacological management could reduce the noted inequalities.
Aims
This umbrella review aimed to synthesise evidence from systematic reviews for pharmacological interventions to manage cardiometabolic outcomes in adults with SMI.
Method
Databases (Embase, MEDLINE, Cochrane Database of Systematic Reviews) were searched from inception to 11 June 2024 for systematic reviews of pharmacological interventions for all cardiometabolic outcomes in adults. Titles, abstracts and full texts were independently screened by two reviewers. Corrected cover area was calculated, and quality was assessed using AMSTAR 2. Results were analysed and a narrative synthesis conducted.
Results
Thirty-three systematic reviews were included following screening of 1723 titles. Metformin, the most commonly studied intervention (n = 18), was effective in preventing and treating weight gain, dyslipidaemia (total cholesterol and triglycerides) and dysglycaemia.
Topiramate and glucagon-like peptide-1 agonists demonstrated efficacy in treating weight gain, but the effect across other parameters was less consistent. Licensed treatments, such as statins for dyslipidaemia, were reviewed in low numbers (n = 2). Nicotine replacement, bupropion and varenicline were effective for smoking cessation, an outcome that can significantly lower cardiometabolic risk.
The corrected cover area was 6.3%, indicating moderate overlap. Most reviews (n = 16, 48%) were rated critically low quality using AMSTAR 2, and the remainder rated either low (n = 7, 21%), moderate (n = 2, 7%) or high quality (n = 7, 24%).
Conclusions
Pharmacological interventions can improve cardiometabolic outcomes in adults with SMI when non-pharmacological interventions are either insufficient alone, impractical or unacceptable. However, licensed treatments have been reviewed in relatively low numbers. Improving cardiometabolic outcomes is a key area in psychiatry, and the results of this review will be important in shaping future guidance.