To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter covers basic theory and constructions of randomized hash functions. Then it presents several applications in complexity theory, including isolation of witnesses, approximate counting and sampling of witnesses, randomness-efficient amplification, and streaming algorithms.
Loneliness has been linked to increased risk of mood disorders, but its relationship with bipolar disorder (BD) and underlying neurobiological mechanisms remain unclear.
Methods
This prospective cohort study utilized data from the UK Biobank, involving 491,472 individuals aged 38–73 years without prior BD diagnosis at baseline (2006–2010). Participants reported loneliness and provided data on demographic, socioeconomic, lifestyle factors, and polygenic risk scores (PRS) for BD. Follow-up extended until 2022, tracking incident BD cases. Neuroimaging analyses examined gray matter volume (GMV) associations with loneliness, considering genetic susceptibility.
Results
Over 16 years, 1,316 participants developed BD. Loneliness was associated with a more than threefold increased risk of BD (hazard ratio [HR], 3.31; 95% CI, 2.97–3.69), which remained significant after adjusting for covariates (HR, 2.83; 95% CI, 2.47–3.23). Neuroimaging revealed that loneliness correlated with widespread reductions in GMV, particularly in regions involved in emotion regulation and social cognition. These neurobiological effects were more pronounced in individuals with higher BD PRS.
Conclusions
Loneliness is prospectively associated with a substantially increased hazard of BD and is linked to extensive brain structural changes, especially in genetically susceptible individuals. These findings highlight the importance of addressing loneliness to potentially mitigate BD risk and its neurobiological impact.
The Old English exile elegies attempt to recuperate loss by reiterating an inverted set of social and physical landmarks, mapping the past onto the present. The familiar imagery of the hall, the lord, and the voices of other human beings – the relationships that constitute community – are not absent in exile: instead, in the absence of the “real thing,” each exile must reconstruct and reiterate a set of replacement landmarks to understand their current situation. Similarly, The Ruin navigates the loss of living memory by imagining the past context necessary to fit its subject back into the fabric of a living world. The frequent depiction of the exile elegies as nostalgic, repetitive, or static is not an incidental formal element, but a core response to the loss of relational landmarks. In exile, alienation from the past—the spoliation of memory as well as the loss of community—suspends the relational self in time. Yet the Old English exiles continue to navigate inverted relational landmarks of identity. The solution is not to abandon relational reiteration; it is instead to seek a new point of departure when familiar points of reference are lost.
In Val Camonica, northern Italy, questions can be made with a ‘do’-support construction. Frequency of ‘do’-support use with activity and stative verbs is measured for various valley dialects through an elicitation experiment. This reveals how use varies from low-frequency, highly optional, and mostly restricted to activity verbs; to high-frequency and obligatory with almost all verbs. The pattern is interpreted as two ends of a grammaticalization chain, from a near lexical ‘do’-support verb to a bleached shell. Geographically, results demonstrate consistent generalization and grammaticalization of ‘do’-support along the valleys, the less grammaticalized, primitive form in the contact zones with other valley dialects, and the more advanced, grammaticalized form in the isolated locations. This is related to the connections between communities, social networks of the speakers, and their attitudes towards or against the ‘do’-support form. It shows how grammaticalization proceeds naturally in the absence of restraining forces.
This chapter examines the often harmful consequences of the deliberate anthropomorphizing of generative AI (GenAI) chatbots by tech companies. Developers intentionally fine-tune systems to be human-like and accommodating, employing strategies like personalization, fostering dependency, offering excessive empathy (sycophancy), adopting a servility model, and promoting endless conversationality, all to maximize user engagement and monetization.
The chapter details how this strategy prioritizes profit over user welfare, leading to unintended and severe consequences, including psychological harm, increased social isolation, and the spread of dangerous misinformation, particularly in fields involving highly vulnerable people, such as mental health and education. The analysis criticizes the lack of accountability from AI companies, which often disclaim responsibility for the harms their products cause.
The fields of human rights and public health intersect in important and interesting ways. Building upon advances in the Health and Human Rights movement in the late twentieth century, practitioners and educators in public health increasingly address the ways in which population health can be advanced and strengthened through an explicitly rights-based approach. Public health, which focuses primarily on community-level prevention, utilizes an interdisciplinary approach in research and teaching to ensure awareness of and respect for human rights. The Right to Health is essential for population well-being, but operationalizing this right has proven challenging and controversial. The need to take a more holistic view of health requires attention to the broader social determinants of health. Public health educators and researchers have started to utilize theoretical and methodological approaches drawn from the natural sciences, social sciences, law, and humanities to address key issues related to health and human rights in a global context.
This chapter integrates empirical research on the pains of imprisonment with psychological and neuroscientific insights into the nature, sources, and effects of social pain, including its connection to the fundamental human need to belong. It argues that social pain provides a comprehensive framework for situating the pains of imprisonment – outlined in Chapter 3– within a unified conceptual construct. This argument rests on three interrelated premises. First, the contexts of exclusion that elicit social pain – social isolation, rejection, and ostracism – closely mirror the layers of exclusion that define the various domains of prison life. Second, the effects of social pain – particularly when pervasive or prolonged – on psychological well-being, behavior, and health significantly overlap with those documented among incarcerated individuals, both during and after imprisonment. Third, the psychological mechanisms that lead people to cause social pain in others, while underestimating its consequences, similarly underpin the logic of punishment, including the tendency to minimize the actual harms of the prison experience. Building on these premises, the chapter develops the book’s central claim: that the real pain of carceral punishment ultimately resides in the systematic threat to the fundamental human need to belong.
Two experiments were conducted for the objective of isolating and characterizing lactic acid bacteria (LAB) from elephant grass and using selected strains as inoculants in elephant grass to enhance its quality as silage. A total of 156 LAB strains were identified in the different periods (0, 1, 3, 7, 14, 28, and 56 days). The main LAB present during the fermentation period were Weissella cibaria at day 1, W. paramesenteroides at day 3, and Lactiplantibacillus plantarum and L. pentosus after the 7th day of fermentation. For inoculation in elephant grass, three strains (L. plantarum 28.19, L. pentosus 28.22 and Lacticaseibacillus casei 28.26) were selected. There was a significant effect of inoculant × period interaction on all silage variables analysed, except for the mould population, which was affected only by fermentation period. At the beginning of fermentation (day 1), silages inoculated with the strains L. plantarum, L. pentosus, and Lc. casei had significantly lower pH compared to the control and commercial inoculant treatments silages. The LAB population in the silages did not differ significantly during the fermentation period, except on days 1 and 7. Silages inoculated with the selected strains had significantly higher crude protein concentrations compared to the control silage. Therefore, selected strains of LAB showed promise for producing better quality elephant grass silage.
Durable social connections are priceless resources for support, companionship, and opportunity. They make life worth living. However, not everyone has equal access to these seemingly free social resources. Like many other valuable things in life, 'social capital' is both a source and a consequence of inequality throughout the population – something that reinforces the status quo and existing social hierarchies. In Friends and Fortunes, the authors painstakingly document that the distribution of social connections in American society is as stark as income inequality. Through detailed analyses and colorful real-life illustrations, they reveal how rich elites hoard both the most prized and the most deceptively frivolous social ties. Drawing on over one hundred measures of social capital from dozens of datasets and over one million people, they explain how social networks create a remarkable and omnipresent web of connections that subtly feed hidden systems of power, prestige, wealth and, ultimately, life chances.
The chapter describes the case of a 45-year-old male with stage 3 HIV who presents to the ED with fever, shortness of breath, pleuritic chest pain, and nonbloody diarrhea. The patient exhibits tachycardia, hypoxia, and a warm, diaphoretic appearance. Initial actions include oxygen supplementation, IV fluids, and labs. The patient is diagnosed with HIV pneumonia, likely Pneumocystis jirovecipneumonia (PCP), and is treated with antibiotics and steroids. Early recognition of fever and hypoxia, along with respiratory isolation, is critical to prevent sepsis. Tests ordered should include CBC, electrolytes, liver function tests, urinalysis and culture, blood cultures, and CXR. Focal infiltrates suggest bacterial pneumonia, while a diffuse interstitial or perihilar, granular pattern on CXR is associated with PCP. Steroids should be given to patients with a partial pressure of arterial oxygen <70 mmHg or an alveolar–arterial gradient of >35 mmHg.
This chapter describes a case of a 45-year-old male with stage 3 HIV who presented to the ED with fever, shortness of breath, pleuritic chest pain, and nonbloody diarrhea. The patient was diagnosed with HIV pneumonia, likely Pneumocystis jiroveci pneumonia(PCP), and was treated with antibiotics, steroids, oxygen supplementation, and IV fluids. The chapter emphasizes the importance of recognizing the symptoms of pneumonia in HIV patients and providing early treatment to prevent sepsis. The chapter also provides guidelines for diagnostic tests and highlights the significance of CD4 counts in the development of pulmonary disorders in HIV patients.
Social network ties represent an important and complex confluence of sundry social processes and their consequences. It is an enduring fact of life that the more socially connected a person is, the better off they are. This goes for well-being, for health, for social stature, for popularity and prestige, for social mobility, and for access to material resources. Social connections give people power. They plug people into a switchboard of opportunities and resources, making them part of a resource-rich social system. Social connections liberate people from the stringencies of what might otherwise be stultifying conditions of everyday life. They create trust and produce the capacity for collective action to deal with local and regional social problems. They help people live longer lives. And social connections generally make life morefun, and richer, in every sense of those terms. It is a bundle of benefits that cannot be unwound. This introductory chapter lays out the primary motivation behind this book, which is an attempt to understand whether everyone has equal access to these valuable social resources, and whether they are so potent as to substitute for other valuable resources, such as wealth and prestige, in shaping people’s life chances.
The overarching question that guides this chapter is: Are social ties, and the resources they represent, equally distributed throughout society? That is, are these connections so free and abundant that they transcend the relentless constraints that people face in obtaining other forms of capital? In particular, do people from disadvantaged backgrounds enjoy the same level of access to such ties as wealthy people? This requires close examination of factors such as people’s connectedness to friends and family; the number of such ties they have and how often they engage them; how much turnover and instability there is in people’s networks; the internal wiring of the networks in which they are embedded, and how that relates to dense connections and brokerage potential; the status and wealth of their contacts; involvement in exchange processes; and connections to community organizations. This chapter navigates the thicket of findings regarding the distribution of these various forms of social capital by first walking through analyses of personal, micro-level connections, and then proceeding upward to more macro-level, organization-oriented indicators. This set of analyses reveals some latent, surprising, and fateful truths about how universally bountiful and reachable these valuable social resources really are.
Chapter 10 examines a different type of long-run consequence. Various counties spent different amounts of time “on the frontier” and had different levels of absolute and relative homesteading.
Social participation is a key determinant of health and wellbeing in later life, yet older adults at risk of marginalization often face barriers that limit their inclusion in society. To promote health equitably, it is essential to take better account of the heterogeneity of older adults and foster their social participation. This study thus aimed to describe and synthesize knowledge about interventions that foster the social participation of older adults at risk of marginalization. Using 61 keywords across six databases, this scoping review identified 29 studies reporting on individualized and collective interventions. Peer assistance and grouping older adults according to interests or shared life experience were identified as key facilitators of participation in the interventions. Limited access to transportation and a lack of activities tailored to the diverse needs of older participants were significant barriers. The findings highlight the importance of collaborating with community organizations to develop sustainable, accessible and adaptable interventions, as well as the value of proximity-based support in individualized approaches. Further studies are needed to evaluate the effectiveness of such interventions. By highlighting strategies to include marginalized older adults in society, this study contributes to advancing health equity for all older adults, especially those at risk of marginalization.
The threat of emergency measures introduced in face of COVID-19 has largely been framed in terms of individual rights. We argue that it is not the protection of the sovereign individual that is most at stake, but the relations between political subjects and the institutions that enable their robust political participation. Drawing on Hannah Arendt's analysis of the ways in which isolation and the incapacity to discern truth or reality condition totalitarianism and are exacerbated by it, we argue that the dangers for the evacuation of democratic politics are stark in our era. We consider contemporary political action in concert in Germany to illustrate this critique of COVID-19 emergency measures. Drawing on the legal concept of “appropriateness,” we explicate how the German critical response to the shutdown is founded on a concern for democratic principles and institutions, and aims to achieve two crucial goals: governmental transparency and social-political solidarity.
Rates of loneliness have increased over the past several decades worldwide, particularly among people with serious mental illnesses. A better understanding of the neurocognitive mechanisms underlying loneliness could provide useful information for the efforts to address this public health problem.
Methods
To investigate these mechanisms, a functional magnetic resonance imaging (fMRI) study was conducted which accounted for known cognitive biases associated with loneliness. Participants with (n = 40) and without (n = 60) psychotic disorders (PD) viewed images of faces that appeared to approach or withdraw from the participants while fMRI data were collected. Following the scanning, participants rated the trustworthiness of the faces, and these ratings were included as weights in the fMRI analyses. Neural responses to approaching versus withdrawing faces were measured, and whole-brain regression analyses, with loneliness as the regressor, were performed.
Results
In the PD and full samples, a higher level of loneliness was significantly associated with greater responses of the hippocampus and areas of the basal ganglia to withdrawing (versus approaching) face stimuli. Moreover, the effects in the hippocampus, but not the basal ganglia, remained significant after controlling for potential confounds such as social activity levels, depression and social anhedonia. Finally, in a subset of the full sample (n = 66), greater hippocampal responses to withdrawing faces predicted greater loneliness 1 year later.
Conclusions
Heightened responses of the hippocampus to withdrawing faces may represent a candidate neurobiological marker of loneliness that could be modified by interventions targeting loneliness.
Demographic changes in rates of living alone, migration, and having no living partner, spouse, or children are leaving more older adults without the typical uncompensated familial and non-familial care partners that are the backbone of long-term care provision. We aimed to understand the precarities and outcomes specifically experienced by older adults without care partners to inform future intervention development. Using the Joanna Briggs Institute guidelines and PRISMA-ScR protocol, we conducted a scoping review of nine databases to map the current peer-reviewed evidence regarding these indivdiduals’ precarities, outcomes, and interventions using the Health Equity Promotion Model (HEPM) as our guiding framework. Our comprehensive search strategy resulted in 5,100 unique articles, 33 of which met our inclusion criteria. Three independent reviewers screened and extracted data, and the first author used deductive content analysis with the pre-specified HEPM framework. Fifteen studies reported precarities related to environmental/structural forces, and psychological, social, behavioral, and biological processes. Twenty-four studies reported adverse health and well-being outcomes with more focus on health than well-being outcomes (19 versus 8). Four studies tested interventions, and reported environmental/structural, social, and behavioral processes and health and well-being outcomes. Only 13 of the 33 reviewed studies set out to explicitly study older adults without care partners, and no studies focused on marginalized sub-groups. This scoping review highlights our lack of understanding of older adults without care partners’ distinctive precarities and outcomes, and the vital research needed to develop and test interventions that effectively address their unique needs.
Within this study, an optimized ultra-wideband (UWB) multi-input multi-output (MIMO) antenna incorporating band-rejection features is introduced for wireless application. The proposed design comprises four circular single-element antenna units that are designed on a Rogers RT/duroid 5880 (tm) support material having an overall size of 80 × 80 × 0.8 mm3 or 0.72λ0 × 0.72λ0 × 0.0072λ0 (λ0 is the free-space wavelength at lowest frequency 2.7 GHz) and positioned perpendicularly. To enhance isolation, cross-shaped extensions are incorporated. Measurement results indicate that this antenna demonstrates an impedance bandwidth of −10 dB, spanning from 2.7 to 11.67 GHz (125%) and penta-notched filters for 3.2–4.0 GHz, 4.49–5.05 GHz, 5.56–6.16 GHz, 8.23–8.56 GHz, and 10.29–11.53 GHz. The presented antenna is capable of filtering signals from WiMAX (3.3–3.7 GHz), N79 band (4.8–4.9 GHz), WLAN downlink (5.725–5.825 GHz), ITU-R (8.275–8.5 GHz) and Ku-band downlink (10.7–11.2 GHz). The antenna exhibits envelope correlation coefficients (ECC) below 0.04 and provides isolation superior to 20 dB. Experimental results indicate that the simulated characteristics closely match the measured ones. The developed MIMO antenna demonstrates strong suitability for ultra-wideband (UWB) wireless communication applications.
Both Ibn Bājja and Ibn Ṭufayl – readers of al-Fārābī in the Islamic West – subscribe to the broad strokes of al-Fārābī’s ideas about humanity. However, in their works on the individual’s mystical journey, they take the gulf between the few and the many so seriously that they ponder whether and how a shared social life between those of excellent and deficient fiṭra is possible or desirable. They both agree with al-Fārābī that human beings share some form of a basic, created nature, or fiṭra; and, broadly speaking, they agree that humans’ fiṭar can be better or worse, which mostly influences people’s access to knowledge. However, they call into question the ability of those of excellent fiṭra to guide or live among those of lesser ones as al-Fārābī had envisioned. As part of this shift in interest, they zoom in on larger, social and political questions. These two Andalusian thinkers powerfully underscore the contested and copious nature of fiṭra and how engagement with fiṭra is part of larger questions about the necessity or possibility of human sociality and the nature of power relations.