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This chapter focuses on impairments in inhibitory control and executive function in addiction. It reviews the role of prefrontal cortical circuits in regulating impulses, evaluating consequences, and guiding goal-directed behavior. Behavioral tasks and neuroimaging studies illustrate how weakened top-down control contributes to compulsive use and relapse. Importantly, the chapter also highlights evidence for neural plasticity and the recovery of control functions with sustained abstinence and intervention.
Bipolar disorder in youths is associated with metabolic dysregulation, impaired inhibitory control and limbic network connectivity changes.
Aims
To investigate whether limbic network connectivity is associated with appetite hormones and inhibitory control in youths with bipolar disorder.
Method
The current study included 68 youths with bipolar disorder and 57 age- and gender-matched controls. They completed clinical assessments, the go/no-go (GNG) task, fasting appetite hormone (leptin, adiponectin, insulin and ghrelin) tests and resting-state functional magnetic resonance imaging. Region of interest (ROI)-to-ROI functional connectivity was analysed across 17 limbic ROIs. Cluster-level inferences were derived by using threshold-free cluster enhancement with family-wise error correction (p < 0.05). Furthermore, associations with appetite hormones and GNG task parameters were investigated.
Results
Compared with the control individuals, youths with bipolar disorder exhibited elevated leptin (p = 0.005) and insulin levels (p < 0.001), poorer performance on the GNG task and hyperconnectivity within the limbic network, identifying a significant cluster comprising the right anterior parahippocampal gyrus (aPHG)–right thalamus and right aPHG–hypothalamus edges (cluster-level family-wise error-corrected p = 0.045). No significant correlations were observed between limbic hyperconnectivity, appetite hormone levels and GNG task performance.
Conclusions
Current cross-sectional cohort indicates that youths with bipolar disorder exhibit concurrent alterations in appetite hormones, inhibitory control and limbic connectivity. These findings provide a characterisation of youth bipolar disorder across multiple indices, although longitudinal studies are necessary to understand how these features relate to long-term clinical trajectories.
This study investigated whether a short-term training session in language switching enhances inhibitory control in English-dominant bilinguals (N = 55) whose second language backgrounds included 17 various languages. The participants completed a pre-training flanker task, a 50-minute numeral-based language-switching task and a post-training flanker task. Results showed significantly reduced flanker effect following the language-switching task. In the switching task, participants exhibited typical switch cost patterns, with slower and less accurate responses on switch trials compared to nonswitch trials. Additionally, switch costs were asymmetrical, with greater costs observed into their first versus second language, consistent with inhibitory control accounts of bilingual language use. Overall, these findings suggest that language switching engages control processes that can have immediate, positive effects on inhibitory control outside the language domain. These results support partial overlap between bilingual language control and domain-general executive processes, highlighting the context-dependent nature of cognitive transfer effects.
Cognitive control supports flexible goal maintenance and conflict resolution. Although bilingual experience has been proposed to enhance its efficiency through sustained language control, emerging evidence suggests these effects reflect adaptive recalibration driven by individual language use rather than domain-general transfer. Here we examined how individual differences in bilingual experience modulate behavioral and neural indices of adaptive attentional control during conflict processing, as indexed by an adaptive Flanker task. Fifty participants (M = 19.6 years) completed the Language and Social Background Questionnaire and an electroencephalography adaptive Flanker task. Event-related potentials in the N100, N200 and P300 windows indexed attentional allocation, conflict detection, and monitoring. Behaviorally, participants showed the expected Flanker interference effect, with no modulation by bilingual experience. In contrast, greater Non-English Social Use, but not overall bilingualism or home use, was associated with attenuated N100s and N200s, suggesting reduced early attentional demands. These neural effects, in the absence of behavioral differences, suggest experience-dependent efficiency in control recruitment rather than enhanced control.
Counterfactual reasoning is the ability to mentally simulate alternative outcomes to past events. Although previous studies have examined specific aspects of counterfactual reasoning, such as outcome direction (upward versus downward) and antecedent structure (additive versus subtractive), little is known about how these different forms are processed within a unified framework. Moreover, although cognitive mechanisms such as working memory and inhibitory control have been previously considered, their role in processing different counterfactual forms remain unclear. The present study consisted of two experiments with adult Turkish speakers. Experiment 1 (N = 44, Mage = 22.21 years) employed a 2 × 2 within-subject design manipulating counterfactual direction (upward versus downward) and antecedent structure (additive versus subtractive). Experiment 2 (N = 40, Mage = 22.17 years) employed a 2 × 2 within-subject design manipulating counterfactual direction and grammatical polarity (consequent-subtractive versus consequent-additive). Individual differences in inhibitory control, working memory and relative clause comprehension were also assessed. The results indicated that upward and consequent-subtractive counterfactuals were processed more quickly than downward and consequent-additive ones. Unexpectedly, additive statements produced quicker responses compared to subtractive ones. Inhibitory control was a strong predictor of performance, whereas working memory had a minimal effect. These results suggest that the processing of counterfactual expressions is influenced by both linguistic and semantic structures.
Methamphetamine is a highly addictive psychostimulant associated with widespread neurobiological alterations. While the acute and chronic effects on the brain have been extensively studied in animal models, far less is known about its impact on the human brain, particularly in the context of inhibitory processing.
Methods
Seventy-two participants (35 who regularly use methamphetamine) completed a paired-pulse somatosensory gating paradigm during magnetoencephalography (MEG). Immediately before the first stimulation of each trial, participants viewed either a substance-related or neutral image. The resulting responses were imaged, and time series were extracted from the peak voxel in the whole-brain maps, which was centered on the contralateral postcentral gyrus. Gating ratios (Stimulation 2/Stimulation 1) were subjected to a linear mixed-effect model, and spontaneous activity in the same voxel was assessed.
Results
We found a significant group-by-condition interaction and a main effect of group, with the latter indicating that controls had significantly stronger gating across both task conditions compared to the methamphetamine group. Interestingly, the interaction revealed that only those in the methamphetamine group exhibited weaker gating in the substance-cue compared to the neutral image condition. Furthermore, gating indices were predictive of processing speed above and beyond the effect of group, while spontaneous gamma during the baseline was elevated in the methamphetamine group compared to controls.
Conclusions
Adults who use methamphetamine exhibit altered gating responses and elevated spontaneous gamma activity in the somatosensory cortices, likely reflecting disruptions in GABAergic circuitry. Substance-related cues accentuated gating deficits, suggesting that cue reactivity may compromise sensory inhibition in this population.
Preterm-born children are at increased risk for executive function (EF) deficits, particularly in inhibitory control. While bilingualism has been linked to enhanced EF in term-born children, its effects on preterm populations are less understood. This study explored whether bilingualism supports inhibitory control in preterm-born children using behavioral and functional near-infrared spectroscopy (fNIRS) data during a Go/No-Go task. Sixteen preterm-born children (ages 6–7), both bilingual and monolingual, were assessed. Bilingual participants demonstrated faster reaction times (RTs) without compromising accuracy and showed lower levels of oxygenated hemoglobin (HbO) in the frontal lobe, indicating more efficient neural effort. Results underscore a distinct neural and behavioral profile in bilingual preterm children during inhibitory control tasks, emphasizing the role of language experience in shaping EF outcomes. These findings suggest that bilingualism may offer cognitive benefits for inhibitory control in preterm-born children and highlight the potential for bilingualism to support EF development in at-risk groups.
This study investigates the relationship between bilingualism, language use, aging, and interference control using the Color–Word Stroop test task. We examined 158 highly proficient Basque–Spanish bilinguals and 84 Spanish monolinguals (aged 30–80 years) to test whether interference control declines with age and whether bilingual adaptations depend on language use frequency. Language experience was assessed using an adapted Language and Social Background Questionnaire and Color–Word Stroop test interference scores were analyzed by regression models. Results showed that interference control declines with age. Group-level differences between bilinguals and monolinguals were not significant once education was included as a covariate, although a small marginal advantage for bilinguals emerged when using education-adjusted T-scores. Within the bilingual group, higher use of the minority language (Basque) in social contexts was associated with significantly better interference control. Social language use showed a stronger relationship with interference control than home use. These findings highlight that bilingual advantages are not uniform but depend on language use frequency and context, contributing to understanding how bilingual experience shapes cognitive control across the lifespan.
This study examined whether self-assessed multilingual proficiency and use of additional languages predict individual differences in inhibitory control (IC) and mind wandering (MW) among UK university students. Sixty-five participants completed a Go/No-Go task measuring response inhibition and the BMW-3 questionnaire, which assessed unintentional, intentional and meta-awareness dimensions of MW. Multilingualism was operationalised using a continuous composite index integrating self-rated proficiency and daily use of non-native languages. The index scores were not significantly associated with response inhibition or meta-awareness. However, higher multilingual proficiency index scores were significantly associated with lower levels of unintentional MW. These findings suggest that, moving beyond categorical comparisons, greater self-reported multilingual proficiency and use of additional languages may support the regulation of internally directed thought, rather than externally triggered IC. Implications for future research and potential applications in education and attention-related interventions are discussed.
Thai researchers developed a new self-report measure of executive functions for adolescents based on Diamond’s framework (the Behavioral Inventory Measure of Executive Functions [BIMEFs]). How it was developed, its psychometric properties, and norms by sex and age are reported here.
Method:
An independent panel of experts evaluated the content validity of BIMEFs. Reliability was checked using Cronbach’s alpha with a sample of 45 secondary students. 1,865 students, ages 12 – 18 years (65% female) from across Thailand participated in the normative study.
Results:
The BIMEFs consists of 42 items that assess inhibitory control (IC), working memory (WM), and cognitive flexibility (CF), including eight subcomponents. For all items, the index of item-objective congruence was >0.5 and Cronbach’s alpha was >0.7. Confirmatory factor analysis (CFA) showed the adjusted goodness of fit index to be 0.9. The strongest sex difference was for IC. Students of 13 years scored lower on EFs overall, IC, WM, CF, and all subcomponents than older students. Self-control, verbal working memory, and being able to change perspectives showed the most pronounced differences by age.
Conclusion:
The BIMEFs, which is designed to be culturally-appropriate for Thailand and cross-culturally generally, is the first EF questionnaire based on Diamond’s framework. It shows good psychometric properties and sensitivity to age and sex differences. It indicates that IC development, at least in Thailand, plateaus earlier than WM and CF and that CF shows a more protracted development during adolescence than IC or WM.
Body-focused repetitive behaviors (BFRBs) include activities like hair pulling and skin-picking that can lead to functional impairment. The neurocognitive underpinnings of BFRBs remain unclear, with inconsistent findings across domains.
Methods:
This online study aimed to investigate the neuropsychological capacities of individuals with self-reported BFRBs. We administered the Go/No-Go test to assess inhibitory control and attention and the Verbal Learning and Memory Test to evaluate learning, recall, and memory confidence. From the 2,129 participants who entered the survey, 412 individuals with self-reported BFRBs and 412 matched controls from the general population were included. Drop-out was high.
Results:
Individuals with BFRBs showed no inhibitory deficits on the Go/No-Go test but made fewer hits on the Go trials compared to controls, indicating attentional lapses. Regarding memory, only immediate recall was worse in the BFRB sample. Controls were biased toward being more confident. When we divided the sample by impairment (>1 SD below the mean of controls), a minority of the BFRB group showed deficits in attention and immediate recall.
Conclusions:
Our findings suggest that neurocognitive deficits are not prevalent in BFRB, affecting less than 20% of our sample. Yet, attentional problems in a subgroup of individuals with BFRB highlights the need to study heterogeneity within BFRBs. Potential moderators such as motivation, stress, and self-stigma remain to be explored. Our findings must be interpreted with caution given the study’s limited generalizability due to its online format, high drop-out rate, and absence of independent diagnostic confirmation.
This study investigated L2 learners’ interpretation of quantifier scope, focusing on the influence of individual differences, including L2 proficiency, working memory (WM) and inhibitory control (IC). A picture selection task using the covered-box paradigm (CBP) was conducted with 70 Chinese-speaking learners of English and a control group of 40 native English speakers. The results revealed that inverse scope (IS) posed particular challenges for L2 learners, leading to reduced, non-target-like access. We attribute this difficulty to factors such as negative L1 transfer, limited L2 input and increased processing demands associated with IS compared to surface scope (SS). More importantly, WM and IC significantly influenced L2 learners’ interpretation patterns, with their effects mediated by L2 proficiency. We also observed individual variation in scope interpretations among native speakers, particularly with negatively quantified (NQ) sentences. This variation provides valuable evidence of individual differences in native speakers’ grammatical knowledge and was partly driven by cognitive factors. Altogether, the findings contribute novel evidence for both domain-general and domain-specific mechanisms underlying quantifier scope interpretation in L2 learners as well as in native speakers.
Executive function is an umbrella term used to describe a collection of complex cognitive processes, which include decision-making, acting as a mechanism of integration rather than a function in itself. It is thought to consist of three main elements: inhibition, working memory and cognitive flexibility – each of which is important in the execution of decisions. Executive functions, like decision-making, are especially difficult to understand and conceptualise due to their abstract nature. Abstract thinking refers to an ability to form ideas that are not concrete, or that cannot be perceived in the present environment – a key contributor to complex decisions that involve integration of past experiences and planning ahead.
In this chapter, we explore key questions about the mental lexicon and brain activity in multilinguals. We begin by discussing research investigating whether languages have separate, integrated, or partially integrated mental representations and how words are processed across languages. We then explore the notion of whether words should be seen as mental representations or brain activity patterns and how lexical processing can be studied in the brain. In doing so, we review advancements in understanding brain function and cognition through multilingual lexicon research using various innovative methods. We address how perspectives on the multilingual mental lexicon can be conceptualized and their implications for theoretical models. Finally, we review research that has contributed to our understanding of bilingual brain function, including short- and long-term changes from multilingualism, and address models integrating behavioral and neurological insights.
In a close replication study of Darcy et al., (2016), Huensch (2024) reported a lack of clear relationships between inhibitory control (IC) and phonological processing, contrary to the initial findings. Given the general unreliability of response-time differences, which are often the basis of IC measures and could potentially mask small effects, we performed secondary analyses on Huensch’s (2024) open data set to investigate (a) the extent to which the reliability of IC measures could be improved using model-based approaches (Hui & Wu, 2024), (b) the correlations between the different IC tasks, and (c) their predictive power for phonological processing, based on the more reliable indices. Results showed that model-based approaches generally improved reliability, and particularly for the Stroop and Simon tasks to acceptable levels. Yet, correlations between IC tasks remained low, and partial correlation and hierarchical regression still failed to reveal significant relationships between IC and phonological processing, further confirming Huensch’s (2024) findings.
Major depressive disorder (MDD) and psychostimulant use disorder (PUD) are common, disabling psychopathologies that pose a major public health burden. They share a common behavioral phenotype: deficits in inhibitory control (IC). However, whether this is underpinned by shared neurobiology remains unclear. In this meta-analytic study, we aimed to define and compare brain functional alterations during IC tasks in MDD and PUD.
Methods
We conducted a systematic literature search on IC task-based functional magnetic resonance imaging studies in MDD and PUD (cocaine or methamphetamine use disorder) in PubMed, Web of Science, and Scopus. We performed a quantitative meta-analysis using seed-based d mapping to define common and distinct neurofunctional abnormalities.
Results
We identified 14 studies comparing IC-related brain activation in a total of 340 MDD patients with 303 healthy controls (HCs), and 11 studies comparing 258 PUD patients with 273 HCs. MDD showed disorder-differentiating hypoactivation during IC tasks in the median cingulate/paracingulate gyri relative to PUD and HC, whereas PUD showed disorder-differentiating hypoactivation relative to MDD and HC in the bilateral inferior parietal lobule. In conjunction analysis, hypoactivation in the right inferior/middle frontal gyrus was common to both MDD and PUD.
Conclusions
The transdiagnostic neurofunctional alterations in prefrontal cognitive control regions may underlie IC deficits shared by MDD and PUD, whereas disorder-differentiating activation abnormalities in midcingulate and parietal regions may account for their distinct features associated with disturbed goal-directed behavior.
Describe the social, cognitive, and biological influences on adolescent decision-making; understand the risk and reward systems of the brain and how these can be influenced by different contexts; evaluate the roles of peer groups, executive functions, and sex differences in adolescent behaviour.
Effects of language switching in bilinguals have been extensively investigated, but the majority of studies have focused on switching in language production. Here we explored intrasentential switching between Chinese and English, employing a self-paced reading paradigm, with Chinese/English using radically different orthographic systems. In addition, we investigated whether L2 (English) proficiency influences switch costs. Results revealed that switch costs emerged only when switching into L1 (Chinese); by contrast, when switching into L2, a less reliable facilitatory effect was observed. L2 proficiency affected reading speed for English stimuli, but it did not directly modulate switch costs. Moreover, we have integrated various findings from previous research and identified that the use of different comparison patterns is a major contributing factor to the inconsistency in results among prior studies. We suggest that in cross-script language switching, switch costs stem from a general cognitive control mechanism rather than from activation within the bilingual mental lexicon.
Knowledge is growing on the essential role of neural circuits involved in aberrant cognitive control and reward sensitivity for the onset and maintenance of binge eating.
Aims
To investigate how the brain's reward (bottom-up) and inhibition control (top-down) systems potentially and dynamically interact to contribute to subclinical binge eating.
Method
Functional magnetic resonance imaging data were acquired from 30 binge eaters and 29 controls while participants performed a food reward Go/NoGo task. Dynamic causal modelling with the parametric empirical Bayes framework, a novel brain connectivity technique, was used to examine between-group differences in the directional influence between reward and executive control regions. We explored the proximal risk factors for binge eating and its neural basis, and assessed the predictive ability of neural indices on future disordered eating and body weight.
Results
The binge eating group relative to controls displayed fewer reward-inhibition undirectional and directional synchronisations (i.e. medial orbitofrontal cortex [mOFC]–superior parietal gyrus [SPG] connectivity, mOFC → SPG excitatory connectivity) during food reward_nogo condition. Trait impulsivity is a key proximal factor that could weaken the mOFC–SPG connectivity and exacerbate binge eating. Crucially, this core mOFC–SPG connectivity successfully predicted binge eating frequency 6 months later.
Conclusions
These findings point to a particularly important role of the bottom-up interactions between cortical reward and frontoparietal control circuits in subclinical binge eating, which offers novel insights into the neural hierarchical mechanisms underlying problematic eating, and may have implications for the early identification of individuals suffering from strong binge eating-associated symptomatology in the general population.
Prior work has yielded mixed findings regarding the relationship between language control and domain-general inhibitory control. Here, we tested the possibility that omnibus language ability would moderate the relationship between language control and inhibitory control in bilingual children. We tested 43 Spanish-English bilingual children (ages 4–5.92 years; 25 females). Children engaged in play-based interactions with their parent, and rates of cross-speaker switches (using a language different from one used by parent) indexed language control. Inhibitory control was measured via a non-verbal flanker task. Analyses revealed that higher frequency of cross-speaker code-switches was associated with better inhibitory control only for children with higher levels of language ability. For children with lower language skills, there was no association between switches and inhibitory control. These findings align with the literature linking cognitive control and language control in bilinguals and extend it to indicate that the strength of the language system constrains this link.