A new framework for modelling vibrational non-equilibrium in high-speed combustion is presented and evaluated. Our model builds upon a wide range of historical modelling paradigms to account for vibrational non-equilibrium exchange mechanisms, including translational–vibrational (T–V), vibrational–vibrational (V–V) and chemical–vibrational (C–V) processes, as well as vibrationally informed chemical reactions. Complementary forms of the T–V and V–V exchange processes are presented and compared, revealing how T–V exchange controls relaxation by driving each species towards vibrational equilibrium, whereas V–V exchange controls redistribution by driving each species towards a common, relative level of vibrational non-equilibrium. A modified form of the V–V exchange probability is proposed to ensure that vibrational energy does not leak into other modes. Additionally, a generalised vibrational efficiency function for complex reactions is derived. This form is subsequently used to derive the C–V exchange rate, which controls creation and destruction of vibrational energy from chemical reactions, resulting in a generalised, coupled vibration–chemistry–vibration model. Each of these processes (T–V, V–V and C–V exchange), as well as the vibrational efficiency function, is defined for general systems. We then examine each process in the context of high-speed combustion applications, in which temperatures are below 5000 K, and implement model simplifications where applicable. This model is used to predict the role of vibrational non-equilibrium in hydrogen chain-branching reactions and is shown to perform similarly to more complex, historical models. The model represents a physically grounded, tractable approach for including vibrational non-equilibrium effects in high-speed combustion applications.