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Chapter 3 discusses why older adults fared poorly during the pandemic and the reasons older people suffered very high rates of morbidity and mortality particularly those in nursing homes, long-term care facilities, and other congregate facilities. Overall individuals over 65 years of age, particularly those living in nursing facilities/homes, experienced the highest mortality rates of any group during the pandemic. As of the week ending October 1, 2023, of the 1.1 million COVID-related deaths in the United States, 790,000 were suffered by people aged 65 and older. Or to express the pattern in another way, although this age group constituted 16 percent of the total population, older adults accounted for 75 percent of the deaths experienced in the United States. There were also similar trends in other countries. The chapter will also consider what should have been done to anticipate and ameliorate this outcome. Chapter 3 additionally raises the issue of age-based discrimination which is a significant human rights violation.
With its focus on role transitions, grief, interpersonal disputes and loneliness, IPT is a relevant psychological treatment modality for older adults who present with depression and common situations that arise with the ageing process. In its application with older adults, the IPT treatment model is retained without any significant changes to the original protocol but significant and important contextual issues must be understood and examined by the practicing therapist. This chapter outlines general issues pertaining to ageing that factor into the assessment task for the Initial Phase of IPT, inform the choice of a focal/problem area in the Middle Phase and guide the implementation of IPT skills and strategies with older adults. Importantly, research has shown that IPT can be easily and successfully applied to depressed older people to alleviate their depressive symptoms and contribute to improved interpersonal functioning and quality of life.
To synthesise evidence on the relationship between food insecurity and social networks among older adults, focusing on conceptualisation and measurement, analytical positionality, directionality of associations and research gaps.
Design:
A scoping review.
Setting:
Global evidence.
Participants:
Adults aged 60 years and older.
Results:
Sixty articles met the inclusion criteria. Research activity increased markedly after 2014, with 45 % published between 2020 and 2025. The median interval between completion of data collection and publication was 4 years. Most were conducted in high-income countries and employed quantitative designs, with limited representation from low- and middle-income countries (LMIC) and few focusing exclusively on older adults. Food insecurity was assessed using diverse instruments, most commonly the Household Food Security Survey Module (HFSSM), the Household Food Insecurity Access Scale (HFIAS) and the Food Insecurity Experience Scale (FIES). Social networks were often proxied by marital status, living arrangements or perceived social support, with few studies employing validated instruments or theoretical frameworks. Most studies treated social networks as determinants of food insecurity, while reverse/bidirectional pathways, as well as more nuanced analytical positions such as networks as mediators/outcomes, were rarely explored.
Conclusions:
This review identifies critical gaps in the evidence, including limited research in LMIC, narrow methodological approaches and a lack of attention to bidirectional pathways, which could indicate strategic entry points for food- or network-based intervention. Addressing these gaps through more diverse, globally informed approaches is essential to deepening the epidemiological understanding of how food insecurity and social networks shape ageing.
Rapid global ageing is increasing the burden of cognitive impairment. Oxidative stress may contribute to cognitive decline, and the oxidative balance score (OBS), which integrates dietary and lifestyle pro- and antioxidants, has an unclear relationship with cognitive function in older adults. This study aimed to investigate the association between the OBS and cognitive function among older adults and to examine potential indirect pathways through circulating oxidative stress-related biomarkers. We used data from 1891 adults aged ≥60 years who participated in the 2011–2014 Chinese Longitudinal Healthy Longevity Survey. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Oxidative stress markers, including albumin, superoxide dismutase, malondialdehyde and plasma 25-hydroxyvitamin D [25(OH)D], were measured at baseline and follow-up. Associations were examined using mixed-effects linear regression models and semi-longitudinal cross-lagged mediation analysis. The median cognitive score was 28 (interquartile range, 23–29). Each one-point higher OBS was associated with a 0·16-point higher MMSE score (β = 0·16, 95 % CI 0·06 to 0·26), and participants in the highest OBS tertile had a 1·12-point higher MMSE score than those in the lowest tertile (β = 1·12, 95 % CI 0·50 to 1·73). In mediation analysis, higher baseline OBS predicted lower plasma 25(OH)D at follow-up (path a = –1·015), and higher baseline 25(OH)D was associated with better cognitive scores at follow-up (path b = 0·025). The indirect effect of OBS on cognition through 25(OH)D was significant (a × b = –0·025). OBS was positively associated with cognitive function, partially mediated by 25(OH)D. Further research is warranted to clarify these mechanisms and implications for cognitive aging.
Extreme weather events (EWEs) and resource insecurities are associated with adverse mental health outcomes, yet little is known about their impacts on older adults in climate-affected settings. We conducted a community-based cross-sectional survey 250 randomly sampled older adults from the Prospective Urban Rural Epidemiology cohort in Moshi, Tanzania (mean age 60.6 years, SD 11.1). Multivariable linear regression examined resource insecurity (food, water, sanitation), EWE exposure, social support, and resilience associations with depressive and anxiety symptoms. In adjusted analyses, low food security (aβ=0.86, 95% CI: 0.54, 1.18), very low food security (aβ=1.07, 95% CI: 0.73, 1.41), sanitation insecurity (aβ=0.05, 95% CI: 0.01, 0.09p = 0.022 e), and past-year EWE exposure (aβ=0.39, 95% CI: 0.07, 0.70) were associated with higher depressive symptoms. Low food security (aβ=0.51, 95% CI: 0.22, 0.79), very low food security (aβ=0.62, 95% CI: 0.32, 0.93), and water insecurity (aβ=0.53, 95% CI: 0.02, 1.03) were associated with higher anxiety ssymptoms, while resilience was associated with lower anxiety symptoms (aβ= −0.07, 95% CI: −0.14,−0.01). Findings highlight interconnected environmental and resource insecurity-related mental health vulnerabilities among older adults, underscoring the importance of integrating resource security and mental health into climate adaptation strategies for older adults in climate-affected low and middle-income settings.
The optimal dietary recommendation for healthy ageing remains unclear. This study examined the association between the Dietary Inflammatory Index (DII) and cardiorespiratory fitness (CRF) in Chinese community-dwelling older adults. Data were drawn from the Guangzhou Nutrition and Health Study’s 3rd and 4th follow-up visits (2017–2021). DII was calculated from a Seventy nine-item validated FFQ, and CRF was assessed on a cycle ergometer using a submaximal constant work rate protocol. VO2max was estimated via the Åstrand-Ryhming Nomogram with age correction, and relative intensity was expressed as percentage of predicted maximal heart rate (%HRmax). Favourable CRF was defined as sex-specific VO2max in the top quartile or %HRmax < 85 %. Among 906 participants (615 women, 291 men; mean age 65·9 ± 5·4 years), those in the lowest DII tertile (anti-inflammatory diet) had higher VO2max than those in the highest tertile (P-trend = 0·048) and greater odds of favourable CRF (OR 1·81, 95 % CI 1·22–2·70), while no significant associations were observed for %HRmax (P-trend = 0·356; OR 1·31, 95 % CI 0·94–1·84). Associations between lower DII and higher VO2max were stronger among physically active participants (P-interaction = 0·049). Compared with consistently high DII, both transition to a low-inflammatory diet (OR 3·01, 95 % CI 1·20–7·51) and persistent adherence to such a diet (OR 2·49, 95 % CI 1·28–4·87) were associated with favourable CRF. These findings suggest that an anti-inflammatory diet is associated with better CRF in older adults, with potential synergistic benefits from physical activity.
Trial registration: This trial was registered at clinicaltrials.gov as NCT03179657.
The Word List subtest of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological battery has been widely used in clinical research to identify and track cognitive disorders. However, normative data and change scores are lacking. The current study aimed to create normative data for the Word List subtest.
Methods:
CERAD Word List data from 1,530 older adults diagnosed as cognitively intact, Mild Cognitive Impairment (MCI), or dementia were seen for two annual visits in a longitudinal observational study from the Uniform Data Set of the National Alzheimer’s Coordinating Center. Multiple linear regression predicted Time 2 scores from Time 1 scores, demographic variables (age, education, sex, and race), and retest interval. Validation included comparing predicted scores to observed scores in the original sample, and additional validation across five comparison groups (cognitively intact, MCI, dementia, worsening cognition, or improving cognition) and one-sample chi-square test of probabilities to compare group classification to predicted categorization based on chance alone.
Results:
The four demographic variables significantly predicted test scores for the six primary scores from the Word List subtest. For change data, when predicted Time 2 scores were compared to observed Time 2 scores, there were significant differences for 4 of the 6 scores, but the effect sizes were small. Significant differences were found across the five comparison groups for Total Recall and Delayed Recall (p-values < .001).
Conclusions:
The current study provides normative data and regression-based change scores for the CERAD Word List subtest for older adults.
Depression in later life is a substantial yet under-recognized public health concern in low- and middle-income countries, including Nigeria, where rapid population aging heightens vulnerability. Evidence from community settings remains limited, particularly in southeastern Nigeria. This study examined the prevalence and sociodemographic factors associated with severe depressive symptoms among community-dwelling adults aged 60 years and older. A cross-sectional survey was conducted from June 2024 to August 2025 across 30 rural and urban communities in five southeastern states, using multistage purposive sampling to recruit 718 eligible participants. Data were collected through interviewer-administered questionnaires incorporating the Geriatric Depression Assessment Questionnaire and the Geriatric Depression Scale – Short Form. Severe depressive symptoms were highly prevalent. Advanced age, female gender, Christian religious affiliation, being married and living with family were significantly associated with higher odds of severe depressive symptoms, while educational level showed no association. Several associated sociodemographic factors contradicted widely held assumptions about the protective nature of traditional social structures, highlighting the need for further investigation into the quality and context of social relationships in later life. These findings underscore the urgent need for routine geriatric mental health screening, community-based support strategies and culturally responsive interventions within Nigeria’s primary care and social welfare systems.
Canada’s rapidly aging population poses unique challenges for rural and remote communities such as the Sunshine Coast, British Columbia.
Objective
Through creative community engagements and community-based participatory research, the Who Cares? project explored experiences of aging and approaches to care by gathering stories from across the Sunshine Coast.
Methods
Qualitative data were gathered from numerous community gatherings and twelve one-on-one interviews.
Findings
Reflexive and collaborative thematic analysis revealed that gaps in health services, staffing, and social supports, which were exacerbated by the COVID-19 pandemic, have since deepened isolation among older adults. Structural barriers included inadequate transportation, housing insecurity, and limited health care access. Findings also revealed that despite these stories of need, communities on the Sunshine Coast demonstrated resilience through informal care networks, volunteerism, and collaborative caregiving practices that transcended institutional settings.
Discussion
These findings point to the need for systemic and community-driven approaches to aging care that prioritize equity, accessibility, and proactive planning, while recognizing care as a shared responsibility embedded in relationships and community assets.
Depression is a major global health concern, yet evidence on depressive symptom severity among older adults with neurodegenerative disorders in Africa remains limited. This study assessed depressive symptom severity and associated sociodemographic, clinical and psychosocial factors in Nigeria.
Methods
This hospital–based cross-sectional study recruited 304 adults aged ≥60 years with clinically confirmed Alzheimer’s disease, Parkinson’s disease or Lewy body dementia from six federally accredited neuropsychiatric hospitals (November 2024–October 2025). Depressive symptoms were assessed using the GDS-15. Descriptive statistics, chi-square tests and multivariable logistic regression were used.
Results
Severe depressive symptoms were observed in 85.2% of participants. Factors associated with severe symptoms included age ≥70 years (AOR = 4.32, 95% CI: 2.20–8.49), male sex (2.80, 1.49–5.27), unmarried/separated status (2.50, 1.22–5.13), living with family (6.27, 3.19–12.31), medication dependence (11.8, 5.88–23.79) and comorbidities (16.3, 7.70–34.57). Tertiary education was inversely associated with severe symptoms (AOR = 0.41, 95% CI: 0.21–0.80).
Conclusion
Severe depressive symptoms were highly prevalent in this clinically selected sample. Integrated depression screening, appropriate clinical management and tailored psychosocial support are warranted.
Interventions for older adults with NCDs and depression should be relevant to the risk factors for NCDs in non-WEIRD populations. We conducted a single-group pilot study of the Ziba Ufa intervention, consisting of problem-solving therapy and health education over 6 weekly sessions delivered by lay counsellors; there was no control group. Participants were opportunistically sampled through outpatient NCD clinics in four sites in Kilimanjaro, Tanzania. We conducted exploratory analyses of the clinical relevance of the health education using self-report survey data, and perceived relevance using qualitative interviews. Thirty-two participants enrolled (88% with hypertension and 44% with type 2 diabetes). Of the 21 participants with height and weight data, 12 (57%) were obese. Advice on weight loss, a sleep routine, and increasing fruit and vegetable consumption may be clinically relevant, but alcohol and tobacco consumption, levels of physical activity and consumption of processed foods with added sugar or salt were self-reported as meeting recommendations; therefore, they may be less clinically relevant. Participants reported acting on the sleep advice more than on the dietary and physical activity advice. This may indicate that sleep advice was perceived as relevant, but dietary and physical activity advice was not.
Population-based longitudinal evidence using administrative healthcare registries remains limited. We aimed to estimate the burden and temporal trends of major depressive disorder (MDD) among individuals aged ≥65 in Lombardy, Italy, 2013 to 2023.
Methods
We conducted a retrospective population-based longitudinal study using multi-source administrative healthcare registries (Lombardy region, Italy), including an open cohort of individuals aged ≥65 years. Incident and prevalent MDD cases were identified from 2013 to 2023, through an algorithm combining hospital discharge records, administrative exemptions, long-term care facility admissions and community psychiatric services. Age-standardised incidence rates per 100,000 person-years and annual prevalence (%) were estimated overall, by sex and age, using the age-truncated (≥65) WHO standard population. Annual percent changes (APCs) and 95% confidence intervals (CIs) were estimated by Poisson regressions.
Results
We identified 19,851 incident MDD cases during the study period. Age-standardised incidence declined from 126.5/100,000 person-years (95% CI 121.7–131.3) in 2013 to 50.6 (47.6–53.7) in 2023, with an APC of 10.8% (−11.8 to −9.7). Age-standardised annual prevalence decreased from 0.94% (0.93–0.95) in 2013 to 0.63% (0.62–0.64) in 2023, corresponding to an annual decline of 3.0% (−4.7 to −1.3). Rates were higher among females. Burden and trends did not differ significantly by sex but across age groups, with the largest reductions among individuals aged 80 years or older.
Conclusions
Administrative data capture clinically diagnosed MDD within the healthcare system, rather than the broader burden in the community. Comparable epidemiological estimates are needed to interpret trends across different settings.
Older adults with mental health (MH) issues often struggle to navigate a complex and fragmented healthcare system, leading to poorer outcomes. To address this, an acute care hospital in Ontario partnered with a community agency to develop an innovative MH Patient Navigation Program supporting older adults across the care continuum. Two Occupational Therapists were hired as Navigators.
Objective
A patient-tracking tool was codesigned to document patient characteristics, provided supports, and outcomes.
Methods
Using a cohort observational design, data were analyzed to describe patient demographics, referral reasons, complexity, navigator interventions, scope of practice, and program impact.
Findings
Patients were mostly female (58.5%) with a mean age of 71.7 years. Common MH conditions included mood disorders (31.4%), substance misuse (21.6%), anxiety (13.7%), and psychotic disorders (11.8%), with 41.1 per cent having a secondary MH condition. Navigators delivered multifaceted supports, with navigation, counselling, and home safety being most common.
Discussion
Findings highlight program value and areas for refinement.
Older adults with multimorbidity (OAMM) commonly receive depression and pain management through primary care, where symptoms are typically assessed through retrospective recall. Even with validated questionnaires, recall bias has been reported in younger populations for both depression and pain. However, recall bias for depression and pain has not been explored in OAMM. We examined discrepancies between prospectively measured and recalled symptoms of depression and pain among OAMM.
Methods:
We analysed data generated from a 14-day pilot feasibility trial of ecological momentary assessment (EMA) in OAMM (N = 18, age range 67–95). We examined discrepancies between retrospectively assessed depression and pain intensity over two weeks compared to follow-up, baseline characteristics correlated with discrepancies, and recency effects.
Results:
We found overreporting across most symptoms, with the largest discrepancies between prospectively recorded and recalled symptom scores for pain intensity and fatigue (d = .49). There was no association between recalled and EMA-measured items for appetite and trouble sleeping. Pain intensity at day 14 was associated with discrepancies in recalled pain (r = −.52, p =.029), and both day 14 mood and negative self-thoughts were associated with discrepancies in trouble concentrating recall (r = −.67, p =.002 and p = −.72, p <.001, respectively) – suggesting recency effects.
Conclusions:
We found preliminary evidence of recall bias among OAMM, including overreporting and recency effects of pain and depression symptoms. Given the reliance on recall during primary care visits, more research is needed.
Les régions rurales présentent une proportion élevée de personnes aînées utilisant plusieurs médicaments. Afin de guider les interventions en santé, cette étude descriptive qualitative visait à comprendre les perceptions de personnes aînées et de personnes proches aidantes vivant en milieu rural quant à la polypharmacie et à la déprescription. Des entrevues individuelles semi-dirigées ont été conduites auprès de personnes âgées de 65 ans et plus prenant cinq médicaments ou plus quotidiennement et de personnes proches aidantes de personnes aînées. L’analyse thématique inductive a révélé que la polypharmacie soulève des inquiétudes, mais qu’elle est perçue comme essentielle. Pour les personnes aînées et les personnes proches aidantes, le médecin demeure une figure de confiance en matière de médicaments. Une approche participative et individualisée par les professionnels de la santé permettrait d’impliquer davantage les personnes et leurs proches pour surmonter les défis liés à la polypharmacie et à la déprescription.
Anxiety is the most prevalent mental health condition, causing significant distress, disability and cost.
Aims
This pilot study assessed the feasibility and acceptability of an eight-week self-directed online exercise intervention, supported by wearable activity monitors (WAMs), for mid-life and later-life adults with clinically significant anxiety, and provided preliminary estimates of effectiveness.
Method
The Exercise Therapy to Reduce Anxiety (ExTRA) project recruited 21 participants aged 40–77 years with Depression, Anxiety and Stress Scales (DASS-21) anxiety scores >7. The ExTRA online platform integrated with the WAMs, and provided information about anxiety, exercise programmes and strategies to help meet national physical activity guidelines, overcome barriers and set goals.
Results
ExTRA was feasible, with a 63% recruitment rate and 100% retention rate. Overall, evaluation questionnaire responses demonstrated high acceptability. At week 8, WAM average steps/day increased by 1358 (p = 0.036, Hedge’s g = −0.47), and fairly/very active minutes (3/6 metabolic equivalents) increased by 81.2 min/week (p = 0.024, g = −0.51), with moderate effect sizes. There was no statistically significant change on the self-report Global Physical Activity Questionnaire. The DASS-21 anxiety score reduction of 2.3 (p = 0.060, g = 0.42) from baseline to week 8 approached statistical significance. DASS-21 stress and depression scores were significantly reduced by 3.9 (p = 0.013, g = 0.57) and 3.7 (p = 0.02, g = 0.53), respectively, from baseline to week 8. There was no significant change in self-efficacy or dementia risk.
Conclusions
The ExTRA intervention is feasible and acceptable, with positive signals for increasing objectively measured physical activity and improving mental health. Findings support and inform the design of randomised controlled trials to assess efficacy of this potentially automated and scalable intervention.
Age-related syntactic processing abilities are not only associated with linguistic competence in later life but also reflect cognitive decline progression. However, findings remain inconsistent regarding older adults’ performance in processing complex syntactic structures. While clinical studies frequently utilize speech pauses to assess syntactic processing abilities and cognitive impairment risk in ageing populations, relatively few investigations have examined how pauses modulate syntactic processing from a perceptual perspective. Using event-related potential (ERP) techniques, this study examined behavioural and electrophysiological responses in 24 Mandarin-speaking older adults and 24 younger adults under conditions of varying syntactic complexity (garden-path [GP] versus ‘non-garden-path’) and pause existence (pause-absent versus pause-present). The results demonstrated significant ageing effects: older participants exhibited longer reaction times (RTs), enhanced P600 amplitudes and reduced mean power in θ-band and α-band compared to younger adults. Notably, pauses improved older adults’ accuracy in processing GP sentences, which elicited larger P600 amplitudes. Furthermore, pauses facilitated increased activation of both N400 and P600 components. These findings collectively suggest that pauses effectively facilitate complex syntactic processing in Mandarin-speaking older adults.
Ageism, defined as stereotypes, prejudices, and discrimination based on age, is a pervasive phenomenon across individuals, settings, historical periods, and cultures. To address the universality of ageism, we explore three main questions: (a) Does ageism happen throughout the course of a person's life? (b) Does ageism permeate all spheres of life? (c) Does ageism exist all around the world? We conclude that although ageism is universal, there are substantial variations in its definition, manifestations, and impact over time and in different sociocultural contexts. The variability identified suggests that we cannot use a one-size-fits-all approach to conceptualize or target ageism, but instead we should adopt a personalized approach, which considers the sociocultural context, the personal attributes of the targets and agents of ageism, and the normative framework concerning ageism at the global and local levels. This title is also available as Open Access on Cambridge Core.
Globally, suicide is more prevalent in older adults compared with any other age group. Although some research has identified risk and protective factors for suicidal behaviour in older adults, further research is needed to provide an up-to-date overview to inform service delivery.
Aims
This study protocol describes mixed-methods research that will examine and identify factors associated with self-harm and suicide in older adults (aged 60 years and older) living in Ireland.
Method
Four stages will be conducted. First, data from the National Self-Harm Registry of Ireland (NSHRI), will be used to examine recent hospital self-harm presentations of older adults, including during the COVID-19 pandemic. Second, a case-series study will examine the adverse life events and psychosocial factors experienced by older adults before dying by suicide, using data from closed coronial files, through the Irish Probable Suicide Deaths Study (IPSDS). Third, risk of suicide following hospital-presenting self-harm will be examined among older adults via data linkage of the NSHRI and IPSDS. Finally, using semi-structured interviews, the service needs of older adults with suicidal behaviour will be explored from the perspectives of older adults, carers and healthcare practitioners.
Conclusions
A comprehensive understanding of adverse events and psychosocial factors associated with the suicidal behaviour of older adults is needed to inform service provision. This proposed research is aligned with (inter)national priorities, mental health promotion and suicide reduction policies. It aims to address gaps in mental healthcare interventions for older adults at risk of suicide.
Depression commonly coexists with cardiovascular diseases (CVDs) in older adults, worsening functional outcomes, medication adherence and survival. In Nigeria, nationally representative data on depression among older adults with CVD are scarce. This study aimed to determine the prevalence of depression, identify key factors associated with depression and examine psychosocial and clinical correlates among older Nigerians receiving CVD care. A hospital-based cross-sectional study was conducted (March 2024–July 2025) across 12 tertiary hospitals representing Nigeria’s six geopolitical zones. A total of 918 adults aged ≥60 years with confirmed CVD were recruited using multistage sampling. Depression and functional status were assessed using a culturally adapted Depression Assessment Questionnaire incorporating the GDS-15 and Lawton IADL Scale. Data were analyzed using chi-square tests and multivariate logistic regression. Depressive symptoms were prevalent in 89.7% of participants. Independent factors associated with depression included age ≥ 70 years (AOR = 2.55), Christian affiliation (AOR = 4.65), alcohol use (AOR = 2.98), CVD duration ≥5 years (AOR = 5.68), comorbidities (AOR = 2.49) and medication dependence (AOR = 9.10). Living with family was protective. Sex, education, residence, smoking and functional status were not significant factors associated with depression. Depression is highly prevalent among older Nigerians with CVD. Integrating routine depression screening and psychosocial support into cardiovascular care is urgently needed.