This study investigates the interaction between shock waves and hydrogen–oxygen cylindrical flames both experimentally and numerically. Experiments are conducted in a newly designed chemically reactive shock tube, where high-speed schlieren imaging captures the detailed flame propagation, deformation and wave dynamics. Following incident shock, flame evolution is primarily dominated by hydrodynamic instability: its upstream interface first flattens, then undergoes phase inversion and subsequently develops into a slender spike. The estimated Darrieus–Landau growth rate is more than an order of magnitude smaller than the Richtmyer–Meshkov instability (RMI)-induced growth rate, confirming that intrinsic flame instabilities play a negligible role and that early-stage evolution is governed predominantly by RMI. However, following reshock, combustion dominates flame evolution, with the upstream interface exhibiting turbulent-like combustion, promoting faster growth of flame length, width and area. High-fidelity simulations employing the Kéromnès mechanism are performed under identical experimental conditions, along with corresponding inert cases for comparison. Pronounced discrepancies are observed: locally, spike roll-up existing in inert cases is largely suppressed in reactive cases; globally, heat release-induced volume expansion drives rapid growth of flame length, width and area. It is found that combustion detaches vortex sheets from the flame interface, suppressing small-scale roll-up and producing abundant disordered small-scale vortical structures within the flame. Shock compression (increasing pressure and temperature) and flame deformation (increasing surface area) significantly enhance heat release, with each mechanism dominating at different stages. Two Damköhler numbers are introduced to characterize the competition between hydrodynamics and chemistry: the flow Damköhler number
$\textit{Da}_{\!f} \gg 1$ initially confirms a hydrodynamically dominated regime following the incident shock and decreases progressively as combustion–flow coupling strengthens after reshock; the diffusion Damköhler number
$\textit{Da}_d \ll 1$ throughout indicates that combustion remains reaction-kinetic-controlled. Both postshock and post-reshock thermodynamic states lie well within the non-explosive region, confirming that reshock-induced turbulent-like combustion is driven by combustion–flow coupling rather than homogeneous chain-branching explosion.