Managed turfgrass covers approximately 16.4 million ha in the United States and generates substantial economic value while providing recreational and ecosystem benefits in urban landscapes. Integrated weed management (IWM) is essential for sustainable turfgrass systems, but its implementation differs markedly from IWM in row-crop production because of distinct management objectives, available tactics, and state and federal regulations. Annual row-crop systems focus on yield optimization, while perennial turfgrass swards prioritize aesthetics, playability, and public safety. Turfgrass management relies heavily on cultural practices (species and cultivar selection, mowing, fertility, irrigation) and the use of chemicals because other strategies that apply to row-crop production, such as cover crops, crop rotation, and tillage, have limited applicability. This review synthesizes current knowledge of turfgrass IWM components, including cultural, physical (e.g., fraise mowing, laser, thermal), biological (e.g., bioherbicides, insects), and chemical (e.g., herbicides, plant growth regulators, organic alternatives, targeted application technologies), and contrasts them with IWM in row-crop production. We further examine federal regulations that affect the management of herbicide-resistant weeds, with particular emphasis on drivers of human health risks and measures to mitigate risks to species listed under the Endangered Species Act (ESA). While managing herbicide resistance is a primary concern in both systems, turfgrass managers face higher per-hectare weed management costs, stricter public-exposure protections, and additional regulatory restrictions. Current ESA mitigation measures are largely based on row-crop models and may overlook turfgrass-specific attributes that reduce environmental exposure risk. Key challenges include limited geospatial data to help characterize turfgrass use sites and inadequate recognition of existing turfgrass management practices as effective mitigation measures, including continuous vegetative cover, no-till, irrigation management, reduced application rates, and precision or spot applications. This review highlights the need for turfgrass-specific research, development, and validation of IWM efforts that integrate emerging technologies chemical and nonchemical tactics, including an assessment of their long-term ecological and economic effects, and for aligning them with regulatory policy to support effective weed management in turfgrass systems.